Merge branch 'master' into staging

36 files changed, 2849 insertions, 453 deletions

diff --git a/doc/guix.texi b/doc/guix.texi
index c49e51b72e..a58ea8f9ec 100644
--- a/doc/guix.texi
+++ b/doc/guix.texi
@@ -18959,7 +18959,6 @@ will fail if @var{device} does not exist.
 @end table
 @end deftp
 
-@anchor{pam-limits-service}
 @cindex session limits
 @cindex ulimit
 @cindex priority
@@ -18967,22 +18966,23 @@ will fail if @var{device} does not exist.
 @cindex jackd
 @cindex nofile
 @cindex open file descriptors
-@deffn {Scheme Procedure} pam-limits-service [#:limits @code{'()}]
-
-Return a service that installs a configuration file for the
+@anchor{pam-limits-service-type}
+@defvar pam-limits-service-type
+Type of the service that installs a configuration file for the
 @uref{http://linux-pam.org/Linux-PAM-html/sag-pam_limits.html,
-@code{pam_limits} module}.  The procedure optionally takes a list of
-@code{pam-limits-entry} values, which can be used to specify
+@code{pam_limits} module}.  The value for this service type is
+a list of @code{pam-limits-entry} values, which can be used to specify
 @code{ulimit} limits and @code{nice} priority limits to user sessions.
+By default, the value is the empty list.
 
 The following limits definition sets two hard and soft limits for all
 login sessions of users in the @code{realtime} group:
 
 @lisp
-(pam-limits-service
- (list
-  (pam-limits-entry "@@realtime" 'both 'rtprio 99)
-  (pam-limits-entry "@@realtime" 'both 'memlock 'unlimited)))
+(service pam-limits-service-type
+         (list
+          (pam-limits-entry "@@realtime" 'both 'rtprio 99)
+          (pam-limits-entry "@@realtime" 'both 'memlock 'unlimited)))
 @end lisp
 
 The first entry increases the maximum realtime priority for
@@ -18994,9 +18994,9 @@ Another useful example is raising the maximum number of open file
 descriptors that can be used:
 
 @lisp
-(pam-limits-service
- (list
-  (pam-limits-entry "*" 'both 'nofile 100000)))
+(service pam-limits-service-type
+         (list
+          (pam-limits-entry "*" 'both 'nofile 100000)))
 @end lisp
 
 In the above example, the asterisk means the limit should apply to any
@@ -19005,7 +19005,7 @@ maximum system value visible in the @file{/proc/sys/fs/file-max} file,
 else the users would be prevented from login in.  For more information
 about the Pluggable Authentication Module (PAM) limits, refer to the
 @samp{pam_limits} man page from the @code{linux-pam} package.
-@end deffn
+@end defvar
 
 @defvar greetd-service-type
 @uref{https://git.sr.ht/~kennylevinsen/greetd, @code{greetd}} is a minimal and
diff --git a/etc/release-manifest.scm b/etc/release-manifest.scm
index 83983c0738..773910ac80 100644
--- a/etc/release-manifest.scm
+++ b/etc/release-manifest.scm
@@ -1,6 +1,7 @@
 ;;; GNU Guix --- Functional package management for GNU
 ;;; Copyright © 2020-2022 Ludovic Courtès <ludo@gnu.org>
 ;;; Copyright © 2020 Jan (janneke) Nieuwenhuizen <janneke@gnu.org>
+;;; Copyright © 2023 Andreas Enge <andreas@enge.fr>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -73,9 +74,7 @@ TARGET."
                  "connman" "network-manager" "network-manager-applet"
                  "openssh" "ntp" "tor"
                  "linux-libre" "grub-hybrid"
-                 ;; FIXME: Add IceCat when Rust is available on i686.
-                 ;;"icecat"
-                 ))
+                 "icecat"))
           %default-xorg-modules))
 
 (define %packages-to-cross-build
diff --git a/etc/teams.scm.in b/etc/teams.scm.in
index 4c95c48543..a8957b4ea0 100644
--- a/etc/teams.scm.in
+++ b/etc/teams.scm.in
@@ -461,7 +461,8 @@ GLib/GIO, GTK, GStreamer and Webkit."
   (team 'lxqt
         #:name "LXQt team"
         #:description "LXQt desktop environment."
-        #:scope (list "gnu/packages/lxqt.scm")))
+        #:scope (list "gnu/packages/lxqt.scm"
+                      "gnu/packages/qt.scm")))
 
 
 (define-member (person "Eric Bavier"
@@ -482,7 +483,7 @@ GLib/GIO, GTK, GStreamer and Webkit."
 
 (define-member (person "Andreas Enge"
                        "andreas@enge.fr")
-  science)
+  lxqt science)
 
 (define-member (person "Tobias Geerinckx-Rice"
                        "me@tobias.gr")
diff --git a/gnu/local.mk b/gnu/local.mk
index 65662f8667..724cd3216a 100644
--- a/gnu/local.mk
+++ b/gnu/local.mk
@@ -782,6 +782,7 @@ GNU_SYSTEM_MODULES =				\
   %D%/tests/messaging.scm			\
   %D%/tests/networking.scm			\
   %D%/tests/package-management.scm		\
+  %D%/tests/pam.scm				\
   %D%/tests/reconfigure.scm			\
   %D%/tests/rsync.scm				\
   %D%/tests/samba.scm				\
diff --git a/gnu/packages/audio.scm b/gnu/packages/audio.scm
index 4f4e7bc947..50ff678095 100644
--- a/gnu/packages/audio.scm
+++ b/gnu/packages/audio.scm
@@ -42,6 +42,7 @@
 ;;; Copyright © 2022 Andy Tai <atai@atai.org>
 ;;; Copyright © 2023 Sergiu Ivanov <sivanov@colimite.fr>
 ;;; Copyright © 2023 David Thompson <dthompson2@worcester.edu>
+;;; Copyright © 2023 Sharlatan Hellseher <sharlatanus@gmail.com>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -66,8 +67,8 @@
   #:use-module (gnu packages backup)
   #:use-module (gnu packages base)
   #:use-module (gnu packages bison)
-  #:use-module (gnu packages build-tools)
   #:use-module (gnu packages boost)
+  #:use-module (gnu packages build-tools)
   #:use-module (gnu packages check)
   #:use-module (gnu packages compression)
   #:use-module (gnu packages curl)
@@ -86,6 +87,7 @@
   #:use-module (gnu packages gnome)
   #:use-module (gnu packages gnunet) ; libmicrohttpd
   #:use-module (gnu packages gperf)
+  #:use-module (gnu packages graphviz)
   #:use-module (gnu packages groff)
   #:use-module (gnu packages gstreamer)
   #:use-module (gnu packages gtk)
@@ -95,6 +97,7 @@
   #:use-module (gnu packages libbsd)
   #:use-module (gnu packages libffi)
   #:use-module (gnu packages libusb)
+  #:use-module (gnu packages linphone)
   #:use-module (gnu packages linux)
   #:use-module (gnu packages llvm)
   #:use-module (gnu packages machine-learning)
@@ -120,8 +123,6 @@
   #:use-module (gnu packages serialization)
   #:use-module (gnu packages sqlite)
   #:use-module (gnu packages telephony)
-  #:use-module (gnu packages linphone)
-  #:use-module (gnu packages linux)
   #:use-module (gnu packages tls)
   #:use-module (gnu packages valgrind)
   #:use-module (gnu packages video)
@@ -3964,6 +3965,55 @@ compression modes.  This package contains command-line programs and library to
 encode and decode wavpack files.")
     (license license:bsd-3)))
 
+(define-public libmixed
+  ;; Release is much outdated.
+  (let ((commit "91e6b9f2438bca41205fade02c9d8f4f938838b6")
+        (revision "0"))
+    (package
+      (name "libmixed")
+      (version (git-version "2.0" revision commit))
+      (source
+       (origin
+         (method git-fetch)
+         (uri (git-reference
+               (url "https://github.com/Shirakumo/libmixed")
+               (commit commit)))
+         (file-name (git-file-name name version))
+         (sha256
+          (base32 "01vwgv8ivpg7a4y95krkgh656mmklsn1k3fmhwp474aj82grd3m4"))))
+      (build-system cmake-build-system)
+      (arguments
+       (list
+        ;; FIXME: (Sharlatan-20230326T121542+0100): Tests failed 1/34, 1 failed,
+        ;; 33 passed. There is not simple way to disable just one test.
+        ;; https://github.com/Shirakumo/libmixed/issues/13
+        #:tests? #f
+        #:configure-flags
+        #~(list "-DBUILD_STATIC=OFF"
+                "-DCMAKE_CXX_FLAGS=-O3 -fPIC"
+                "-DCMAKE_C_FLAGS=-O3 -fPIC")
+        #:phases
+        #~(modify-phases %standard-phases
+            (add-after 'unpack 'fix-paths
+              (lambda _
+                (substitute* "CMakeLists.txt"
+                  (("/usr/local") #$output))))
+            (replace 'check
+              (lambda* (#:key tests? #:allow-other-keys)
+                (when tests?
+                  (invoke "./tester")))))))
+      (native-inputs (list doxygen graphviz))
+      (inputs (list mpg123 ncurses))
+      (home-page "https://github.com/Shirakumo/libmixed")
+      (synopsis "Low-level audio mixer pipeline library")
+      (description
+       "Libmixed is a library for real-time audio processing pipelines for use
+in audio/video/games.  It can serve as a base architecture for complex DSP
+systems.")
+      (license (list license:bsd-2 ; libsamplerate
+                     license:gpl2 ; spiralfft
+                     license:zlib)))))
+
 (define-public libmodplug
   (package
     (name "libmodplug")
diff --git a/gnu/packages/benchmark.scm b/gnu/packages/benchmark.scm
index 52970f58fe..0cc8def918 100644
--- a/gnu/packages/benchmark.scm
+++ b/gnu/packages/benchmark.scm
@@ -473,7 +473,7 @@ test any system or protocol.
 
 Note: Locust will complain if the available open file descriptors limit for
 the user is too low.  To raise such limit on a Guix System, refer to
-@samp{info guix --index-search=pam-limits-service}.")
+@samp{info guix --index-search=pam-limits-service-type}.")
     (license license:expat)))
 
 (define-public interbench
diff --git a/gnu/packages/bioconductor.scm b/gnu/packages/bioconductor.scm
index fe446df67a..2e529d4770 100644
--- a/gnu/packages/bioconductor.scm
+++ b/gnu/packages/bioconductor.scm
@@ -640,6 +640,50 @@ from several related annotation packages.")
 data.")
     (license license:artistic2.0)))
 
+(define-public r-illuminahumanmethylation450kmanifest
+  (package
+    (name "r-illuminahumanmethylation450kmanifest")
+    (version "0.4.0")
+    (source (origin
+              (method url-fetch)
+              (uri (bioconductor-uri
+                    "IlluminaHumanMethylation450kmanifest"
+                    version 'annotation))
+              (sha256
+               (base32
+                "0qx75xwifrbkqmbkd8dhf44c34ibmbivqh7y8rvgrsizmi5ybcj1"))))
+    (properties `((upstream-name . "IlluminaHumanMethylation450kmanifest")))
+    (build-system r-build-system)
+    (propagated-inputs (list r-minfi))
+    (home-page
+     "https://bioconductor.org/packages/IlluminaHumanMethylation450kmanifest")
+    (synopsis "Annotation for Illumina's 450k methylation arrays")
+    (description "This package provides a manifest for Illumina's 450k array
+data.")
+    (license license:artistic2.0)))
+
+(define-public r-illuminahumanmethylationepicanno-ilm10b4-hg19
+  (package
+    (name "r-illuminahumanmethylationepicanno-ilm10b4-hg19")
+    (version "0.6.0")
+    (source (origin
+              (method url-fetch)
+              (uri (bioconductor-uri
+                    "IlluminaHumanMethylationEPICanno.ilm10b4.hg19"
+                    version 'annotation))
+              (sha256
+               (base32
+                "0687b4k8hwfc18qgdd9ypv1skp37jd204fszba0gmrv3dc92i09c"))))
+    (properties `((upstream-name . "IlluminaHumanMethylationEPICanno.ilm10b4.hg19")))
+    (build-system r-build-system)
+    (propagated-inputs (list r-minfi))
+    (home-page
+     "https://doi.org/doi:10.18129/B9.bioc.IlluminaHumanMethylationEPICanno.ilm10b4.hg19")
+    (synopsis "Annotation for Illumina's EPIC methylation arrays")
+    (description
+     "This is an annotation package for Illumina's EPIC methylation arrays.")
+    (license license:artistic2.0)))
+
 (define-public r-org-ce-eg-db
   (package
     (name "r-org-ce-eg-db")
@@ -1392,6 +1436,26 @@ curated cell type labels, for use in procedures like automated annotation of
 single-cell data or deconvolution of bulk RNA-seq.")
     (license license:gpl3)))
 
+(define-public r-champdata
+  (package
+    (name "r-champdata")
+    (version "2.30.0")
+    (source (origin
+              (method url-fetch)
+              (uri (bioconductor-uri "ChAMPdata" version 'experiment))
+              (sha256
+               (base32
+                "0rz762szfl02h4d3dj7ckd41ji9mdsja8nxqw6fl086z337041zw"))))
+    (properties `((upstream-name . "ChAMPdata")))
+    (build-system r-build-system)
+    (propagated-inputs (list r-biocgenerics r-genomicranges))
+    (home-page "https://bioconductor.org/packages/ChAMPdata")
+    (synopsis "Data packages for ChAMP package")
+    (description
+     "This package provides datasets needed for ChAMP including a test dataset
+and blood controls for CNA analysis.")
+    (license license:gpl3)))
+
 (define-public r-chromstardata
   (package
     (name "r-chromstardata")
@@ -1434,6 +1498,63 @@ display copy number variation.  Files are stored as GRanges objects from the
 GenomicRanges Bioconductor package.")
     (license license:gpl2)))
 
+(define-public r-flowsorted-blood-450k
+  (package
+    (name "r-flowsorted-blood-450k")
+    (version "1.36.0")
+    (source (origin
+              (method url-fetch)
+              (uri (bioconductor-uri "FlowSorted.Blood.450k"
+                                     version 'experiment))
+              (sha256
+               (base32
+                "1ha9qsp5g3g2yhnk574x6xhg95bb29ywvmg3ns1c50z69v6wbraq"))))
+    (properties `((upstream-name . "FlowSorted.Blood.450k")))
+    (build-system r-build-system)
+    (propagated-inputs (list r-minfi))
+    (home-page "https://bioconductor.org/packages/FlowSorted.Blood.450k")
+    (synopsis
+     "Illumina HumanMethylation data on sorted blood cell populations")
+    (description
+     "This package provides raw data objects for the Illumina 450k DNA
+methylation microarrays, and an object depicting which CpGs on the array are
+associated with cell type.")
+    (license license:artistic2.0)))
+
+(define-public r-flowsorted-blood-epic
+  (package
+    (name "r-flowsorted-blood-epic")
+    (version "2.2.0")
+    (source (origin
+              (method url-fetch)
+              (uri (bioconductor-uri "FlowSorted.Blood.EPIC" version
+                                     'experiment))
+              (sha256
+               (base32
+                "1vybj69jxnirqg6ik03q3pb1vv23z8mir7wpi2ys7iljf5ixzgl1"))))
+    (properties `((upstream-name . "FlowSorted.Blood.EPIC")))
+    (build-system r-build-system)
+    (propagated-inputs
+     (list r-annotationhub
+           r-experimenthub
+           r-genefilter
+           r-minfi
+           r-nlme
+           r-quadprog
+           r-s4vectors
+           r-summarizedexperiment))
+    (native-inputs (list r-knitr))
+    (home-page "https://github.com/immunomethylomics/FlowSorted.Blood.EPIC")
+    (synopsis
+     "Illumina EPIC data on immunomagnetic sorted peripheral adult blood cells")
+    (description
+     "This package provides raw data objects to be used for blood cell
+proportion estimation in minfi and similar packages.  The
+@code{FlowSorted.Blood.EPIC} object is based in samples assayed by Brock
+Christensen and colleagues; for details see Salas et al. 2018.
+https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE110554.")
+    (license license:gpl3)))
+
 (define-public r-genelendatabase
   (package
     (name "r-genelendatabase")
@@ -1523,6 +1644,28 @@ cluster labels and labels identifying spiked in cells.  Column metadata
 includes channel names, protein marker names, and protein marker classes.")
     (license license:expat)))
 
+(define-public r-illumina450probevariants-db
+  (package
+    (name "r-illumina450probevariants-db")
+    (version "1.34.0")
+    (source (origin
+              (method url-fetch)
+              (uri (bioconductor-uri "Illumina450ProbeVariants.db"
+                                     version 'experiment))
+              (sha256
+               (base32
+                "1c1iqxi17s1a1sa1vab2ma7pjq1dxal7ibsiahj66ys0pa4sm42p"))))
+    (properties `((upstream-name . "Illumina450ProbeVariants.db")))
+    (build-system r-build-system)
+    (home-page "https://bioconductor.org/packages/Illumina450ProbeVariants.db")
+    (synopsis
+     "Variant data from 1000 Genomes Project for Illumina HumanMethylation450 Bead Chip probes")
+    (description
+     "This package includes details on variants for each probe on the 450k
+bead chip for each of the four populations (Asian, American, African and
+European).")
+    (license license:gpl3)))
+
 (define-public r-italicsdata
   (package
     (name "r-italicsdata")
@@ -1565,6 +1708,79 @@ gene expression indicate a role for enhancer priming in immune response\", publi
 in Nature Genetics, January 2018.")
     (license license:gpl2+)))
 
+(define-public r-minfidata
+  (package
+    (name "r-minfidata")
+    (version "0.44.0")
+    (source (origin
+              (method url-fetch)
+              (uri (bioconductor-uri "minfiData" version 'experiment))
+              (sha256
+               (base32
+                "15s3kc629m2c78vkidmp6kcc28sn1wzjzrxazmd8z7x8cdad3q4g"))))
+    (properties `((upstream-name . "minfiData")))
+    (build-system r-build-system)
+    (propagated-inputs
+     (list r-illuminahumanmethylation450kanno-ilmn12-hg19
+           r-illuminahumanmethylation450kmanifest
+           r-minfi))
+    (home-page "https://bioconductor.org/packages/minfiData")
+    (synopsis "Example data for the Illumina Methylation 450k array")
+    (description
+     "This package provides data from 6 samples across 2 groups from 450k
+methylation arrays.")
+    (license license:artistic2.0)))
+
+(define-public r-missmethyl
+  (package
+    (name "r-missmethyl")
+    (version "1.32.1")
+    (source (origin
+              (method url-fetch)
+              (uri (bioconductor-uri "missMethyl" version))
+              (sha256
+               (base32
+                "1rrm8m68kgjkrw1wdli5lrwqlavhbm490zgnj5vafzpvx7xajfma"))))
+    (properties `((upstream-name . "missMethyl")))
+    (build-system r-build-system)
+    (propagated-inputs
+     (list r-annotationdbi
+           r-biasedurn
+           r-biobase
+           r-biocgenerics
+           r-genomicranges
+           r-go-db
+           r-illuminahumanmethylation450kanno-ilmn12-hg19
+           r-illuminahumanmethylation450kmanifest
+           r-illuminahumanmethylationepicanno-ilm10b4-hg19
+           r-illuminahumanmethylationepicmanifest
+           r-iranges
+           r-limma
+           r-methylumi
+           r-minfi
+           r-org-hs-eg-db
+           r-ruv
+           r-s4vectors
+           r-statmod
+           r-stringr
+           r-summarizedexperiment))
+    (native-inputs (list r-knitr))
+    (home-page "https://bioconductor.org/packages/missMethyl")
+    (synopsis "Analyzing Illumina HumanMethylation BeadChip data")
+    (description
+     "This is a package for normalization, testing for differential
+variability and differential methylation and gene set testing for data from
+Illumina's Infinium HumanMethylation arrays.  The normalization procedure is
+subset-quantile within-array normalization (SWAN), which allows Infinium I and
+II type probes on a single array to be normalized together.  The test for
+differential variability is based on an empirical Bayes version of Levene's
+test.  Differential methylation testing is performed using RUV, which can
+adjust for systematic errors of unknown origin in high-dimensional data by
+using negative control probes.  Gene ontology analysis is performed by taking
+into account the number of probes per gene on the array, as well as taking
+into account multi-gene associated probes.")
+    (license license:gpl2)))
+
 (define-public r-msdata
   (package
     (name "r-msdata")
@@ -2516,13 +2732,13 @@ problems.")
 (define-public r-amaretto
   (package
     (name "r-amaretto")
-    (version "1.13.0")
+    (version "1.14.0")
     (source (origin
               (method url-fetch)
               (uri (bioconductor-uri "AMARETTO" version))
               (sha256
                (base32
-                "18w65sf3h4yzw9v5xgkalxnkmgzgsx100v7qc7z4ifx10lgpji5n"))))
+                "06j75c4j71fkkw5s52nbzb3k084y2f4v4h3js9dgsxxrd6jkzfz9"))))
     (properties `((upstream-name . "AMARETTO")))
     (build-system r-build-system)
     (propagated-inputs
@@ -2761,13 +2977,13 @@ for use in Bioconductor’s AnnotationHub.")
 (define-public r-anvil
   (package
     (name "r-anvil")
-    (version "1.10.1")
+    (version "1.10.2")
     (source (origin
               (method url-fetch)
               (uri (bioconductor-uri "AnVIL" version))
               (sha256
                (base32
-                "0iqsffkrxv28g9cddx2w05f2dbscwxhh6bpizwa8xaxhvn5bcpsv"))))
+                "1j7n8c47j3njd5rnlrj8bkn4q5z7jpm0c9rdq1mlwd2i1yy9fz9b"))))
     (properties `((upstream-name . "AnVIL")))
     (build-system r-build-system)
     (propagated-inputs
@@ -4533,6 +4749,46 @@ spent loading the full derfinder package when running the F-statistics
 calculation in parallel.")
     (license license:artistic2.0)))
 
+(define-public r-dmrcate
+  (package
+    (name "r-dmrcate")
+    (version "2.12.0")
+    (source (origin
+              (method url-fetch)
+              (uri (bioconductor-uri "DMRcate" version))
+              (sha256
+               (base32
+                "0iphlsbam5fcxbj5j0cmqk3wz5ykwz0mvk3qbrhzxbpf2h4w2qib"))))
+    (properties `((upstream-name . "DMRcate")))
+    (build-system r-build-system)
+    (propagated-inputs
+     (list r-bsseq
+           r-dss
+           r-edger
+           r-experimenthub
+           r-genomeinfodb
+           r-genomicranges
+           r-gviz
+           r-iranges
+           r-limma
+           r-minfi
+           r-missmethyl
+           r-plyr
+           r-s4vectors
+           r-summarizedexperiment))
+    (native-inputs (list r-knitr))
+    (home-page "https://bioconductor.org/packages/DMRcate")
+    (synopsis "Methylation array and sequencing spatial analysis methods")
+    (description
+     "This is a package for de novo identification and extraction of
+@dfn{differentially methylated regions} (DMRs) from the human genome using
+@dfn{Whole Genome Bisulfite Sequencing} (WGBS) and Illumina Infinium
+Array (450K and EPIC) data.  It provides functionality for filtering probes
+possibly confounded by SNPs and cross-hybridisation.  It includes
+@code{GRanges} generation and plotting functions.")
+    ;; GPLv3 with additional liability disclaimer.
+    (license license:gpl3)))
+
 (define-public r-drimseq
   (package
     (name "r-drimseq")
@@ -4568,6 +4824,32 @@ makes available functions for visualization and exploration of the data and
 results.")
     (license license:gpl3+)))
 
+(define-public r-dss
+  (package
+    (name "r-dss")
+    (version "2.46.0")
+    (source (origin
+              (method url-fetch)
+              (uri (bioconductor-uri "DSS" version))
+              (sha256
+               (base32
+                "1qm0pq6495fn2zrbddaadb1w01ry76rg8mmbmxf3zws9pww48jgf"))))
+    (properties `((upstream-name . "DSS")))
+    (build-system r-build-system)
+    (propagated-inputs (list r-biobase r-biocparallel r-bsseq))
+    (native-inputs (list r-knitr))
+    (home-page "https://bioconductor.org/packages/DSS")
+    (synopsis "Dispersion shrinkage for sequencing data")
+    (description
+     "DSS is an R library performing differential analysis for count-based
+sequencing data.  It detects @dfn{differentially expressed genes} (DEGs) from
+RNA-seq, and differentially methylated loci or regions (DML/DMRs) from
+@dfn{bisulfite sequencing} (BS-seq).  The core of DSS is a dispersion
+shrinkage method for estimating the dispersion parameter from Gamma-Poisson or
+Beta-Binomial distributions.")
+    ;; Any version of the GPL
+    (license (list license:gpl2+ license:gpl3+))))
+
 (define-public r-bluster
   (package
    (name "r-bluster")
@@ -4763,6 +5045,28 @@ domains etc.) from quantification of all types of RNASeq by tools such as
 Kallisto, Salmon, StringTie, Cufflinks/Cuffdiff etc.")
     (license license:gpl2+)))
 
+;; This is a CRAN package, but it depends on qvalue from Bioconductor.
+(define-public r-isva
+  (package
+    (name "r-isva")
+    (version "1.9")
+    (source (origin
+              (method url-fetch)
+              (uri (cran-uri "isva" version))
+              (sha256
+               (base32
+                "05qx9q0kg4ma23v4abhihw0vz017nq6hv2jzsiqx4d20ngh1dl4z"))))
+    (properties `((upstream-name . "isva")))
+    (build-system r-build-system)
+    (propagated-inputs (list r-fastica r-jade r-qvalue))
+    (home-page "https://cran.r-project.org/package=isva")
+    (synopsis "Independent surrogate variable analysis")
+    (description
+     "Independent Surrogate Variable Analysis is an algorithm for feature
+selection in the presence of potential confounding factors (see Teschendorff
+AE et al 2011, <doi: 10.1093/bioinformatics/btr171>).")
+    (license license:gpl2)))
+
 (define-public r-italics
   (package
     (name "r-italics")
@@ -5239,14 +5543,14 @@ used by @code{ensembldb}, @code{Organism.dplyr}, and other packages.")
 (define-public r-annotationforge
   (package
     (name "r-annotationforge")
-    (version "1.40.1")
+    (version "1.40.2")
     (source
      (origin
        (method url-fetch)
        (uri (bioconductor-uri "AnnotationForge" version))
        (sha256
         (base32
-         "16wdcl56d5i8wrmin610kzs9ldy7h9w5fbnysjb1crkcgbikq1yy"))))
+         "1ab7nl9zrlhlkwjrjr69zqq5hy9a8rp457hcr075n8qm5r5lf6wd"))))
     (properties
      `((upstream-name . "AnnotationForge")))
     (build-system r-build-system)
@@ -5388,13 +5692,13 @@ on Bioconductor or which replace R functions.")
 (define-public r-biomart
   (package
     (name "r-biomart")
-    (version "2.54.0")
+    (version "2.54.1")
     (source (origin
               (method url-fetch)
               (uri (bioconductor-uri "biomaRt" version))
               (sha256
                (base32
-                "0c6agi652kbffqwd1r3c22ncisqaiy3gqbc9fz13767rr71im6lq"))))
+                "13nhp97cklaimc3cd931hz584nc58szk2gyxrkfhp7knfli6jbpi"))))
     (properties
      `((upstream-name . "biomaRt")))
     (build-system r-build-system)
@@ -5653,6 +5957,68 @@ genome data packages and support for efficient SNP representation.")
 analysis.")
     (license license:artistic2.0)))
 
+(define-public r-champ
+  (package
+    (name "r-champ")
+    (version "2.28.0")
+    (source (origin
+              (method url-fetch)
+              (uri (bioconductor-uri "ChAMP" version))
+              (sha256
+               (base32
+                "10ss0a3miqrx92vy1r1h5rv3mnjn4iyl32q86s0x59d3fvqp2cx1"))))
+    (properties `((upstream-name . "ChAMP")))
+    (build-system r-build-system)
+    (propagated-inputs
+     (list r-bumphunter
+           r-champdata
+           r-combinat
+           r-dendextend
+           r-dmrcate
+           r-dnacopy
+           r-doparallel
+           r-dt
+           r-genomicranges
+           r-ggplot2
+           r-globaltest
+           r-goseq
+           r-hmisc
+           r-illumina450probevariants-db
+           r-illuminahumanmethylation450kmanifest
+           r-illuminahumanmethylationepicanno-ilm10b4-hg19
+           r-illuminahumanmethylationepicmanifest
+           r-illuminaio
+           r-impute
+           r-isva
+           r-kpmt
+           r-limma
+           r-marray
+           r-matrixstats
+           r-minfi
+           r-missmethyl
+           r-plotly
+           r-plyr
+           r-preprocesscore
+           r-prettydoc
+           r-quadprog
+           r-qvalue
+           r-rcolorbrewer
+           r-rmarkdown
+           r-rpmm
+           r-shiny
+           r-shinythemes
+           r-sva
+           r-watermelon))
+    (native-inputs (list r-knitr))
+    (home-page "https://bioconductor.org/packages/ChAMP")
+    (synopsis
+     "Chip analysis methylation pipeline for Illumina HumanMethylation450 and EPIC")
+    (description
+     "The package includes quality control metrics, a selection of
+normalization methods and novel methods to identify differentially methylated
+regions and to highlight copy number alterations.")
+    (license license:gpl3)))
+
 (define-public r-chipseeker
   (package
     (name "r-chipseeker")
@@ -6145,6 +6511,48 @@ other types of genomic data that produce counts, including ChIP-seq, SAGE and
 CAGE.")
     (license license:gpl2+)))
 
+(define-public r-enmix
+  (package
+    (name "r-enmix")
+    (version "1.34.02")
+    (source (origin
+              (method url-fetch)
+              (uri (bioconductor-uri "ENmix" version))
+              (sha256
+               (base32
+                "0rn541xfsxfdyzy3dn727bwrfpkgp12282lax7xg1j8584mk4pcf"))))
+    (properties `((upstream-name . "ENmix")))
+    (build-system r-build-system)
+    (propagated-inputs
+     (list r-annotationhub
+           r-biobase
+           r-doparallel
+           r-dynamictreecut
+           r-experimenthub
+           r-foreach
+           r-genefilter
+           r-geneplotter
+           r-gplots
+           r-gtools
+           r-illuminaio
+           r-impute
+           r-iranges
+           r-matrixstats
+           r-minfi
+           r-preprocesscore
+           r-quadprog
+           r-rpmm
+           r-s4vectors
+           r-summarizedexperiment))
+    (native-inputs (list r-knitr))
+    (home-page "https://bioconductor.org/packages/release/bioc/html/ENmix.html")
+    (synopsis
+     "Quality control and analysis tools for Illumina DNA methylation BeadChip")
+    (description
+     "This package provides tools for quality control, analysis and
+visualization of Illumina DNA methylation array data.")
+    (license license:artistic2.0)))
+
 (define-public r-ensembldb
   (package
     (name "r-ensembldb")
@@ -6524,6 +6932,30 @@ profiles and assignment of a status (gain, normal or loss) to each chromosomal
 regions identified.")
     (license license:gpl2)))
 
+(define-public r-globaltest
+  (package
+    (name "r-globaltest")
+    (version "5.52.1")
+    (source (origin
+              (method url-fetch)
+              (uri (bioconductor-uri "globaltest" version))
+              (sha256
+               (base32
+                "1g5dv3bw0fj8sq0hsr8c7nh6n1rzvx1bisqlyqjqq3f8lsyb51kb"))))
+    (properties `((upstream-name . "globaltest")))
+    (build-system r-build-system)
+    (propagated-inputs
+     (list r-annotate r-annotationdbi r-biobase r-survival))
+    (home-page "https://bioconductor.org/packages/globaltest")
+    (synopsis
+     "Test groups of covariates for association with a response variable")
+    (description
+     "The global test tests groups of covariates (or features) for association
+with a response variable.  This package implements the test with diagnostic
+plots and multiple testing utilities, along with several functions to
+facilitate the use of this test for gene set testing of GO and KEGG terms.")
+    (license license:gpl2+)))
+
 (define-public r-gostats
   (package
     (name "r-gostats")
@@ -7962,14 +8394,14 @@ the available RAM.")
 (define-public r-rhdf5filters
   (package
     (name "r-rhdf5filters")
-    (version "1.10.0")
+    (version "1.10.1")
     (source
      (origin
        (method url-fetch)
        (uri (bioconductor-uri "rhdf5filters" version))
        (sha256
         (base32
-         "17x2a3122mm3z9qnalw25am2x08cfpm17nwhigabid3ha3d2mgz1"))))
+         "14rkr0fisy7qrvjikpnwxwag79205hdxy6nkpwz501li4fr1rbnp"))))
     (properties `((upstream-name . "rhdf5filters")))
     (build-system r-build-system)
     (propagated-inputs
@@ -8368,6 +8800,33 @@ sequence motif occurrences across a large set of sequences centred at a common
 reference point and sorted by a user defined feature.")
     (license license:gpl3+)))
 
+(define-public r-shinymethyl
+  (package
+    (name "r-shinymethyl")
+    (version "1.34.0")
+    (source (origin
+              (method url-fetch)
+              (uri (bioconductor-uri "shinyMethyl" version))
+              (sha256
+               (base32
+                "1xbadc4xszcqh211r8z0wp417f17aczz834icli17mcsl996ln3a"))))
+    (properties `((upstream-name . "shinyMethyl")))
+    (build-system r-build-system)
+    (propagated-inputs
+     (list r-biocgenerics
+           r-illuminahumanmethylation450kmanifest
+           r-matrixstats
+           r-minfi
+           r-rcolorbrewer
+           r-shiny))
+    (native-inputs (list r-knitr))
+    (home-page "https://bioconductor.org/packages/shinyMethyl")
+    (synopsis "Interactive visualization for Illumina methylation arrays")
+    (description
+     "This package provides an interactive tool for visualizing Illumina
+methylation array data.  Both the 450k and EPIC array are supported.")
+    (license license:artistic2.0)))
+
 (define-public r-shortread
   (package
     (name "r-shortread")
@@ -14341,6 +14800,46 @@ gene fusion discovery.  It can be applied to all major sequencing techologies
 and to both short and long sequence reads.")
     (license license:gpl3)))
 
+(define-public r-flowai
+  (package
+    (name "r-flowai")
+    (version "1.28.0")
+    (source (origin
+              (method url-fetch)
+              (uri (bioconductor-uri "flowAI" version))
+              (sha256
+               (base32
+                "18zrlnjw89iglxhw65ys8x4r44pdzp5chrgwx7w44sh7yd8576g9"))))
+    (properties `((upstream-name . "flowAI")))
+    (build-system r-build-system)
+    (propagated-inputs
+     (list r-changepoint
+           r-flowcore
+           r-ggplot2
+           r-knitr
+           r-plyr
+           r-rcolorbrewer
+           r-reshape2
+           r-rmarkdown
+           r-scales))
+    (native-inputs (list r-knitr))
+    (home-page "https://bioconductor.org/packages/flowAI")
+    (synopsis
+     "Automatic and interactive quality control for flow cytometry data")
+    (description
+     "This package is able to perform an automatic or interactive quality
+control on FCS data acquired using flow cytometry instruments.  By evaluating
+three different properties:
+
+@enumerate
+@item flow rate
+@item signal acquisition, and
+@item dynamic range,
+@end enumerate
+
+the quality control enables the detection and removal of anomalies.")
+    (license license:gpl2+)))
+
 (define-public r-flowutils
   (package
     (name "r-flowutils")
@@ -14616,14 +15115,14 @@ statistics to the plot.")
 (define-public r-flowclust
   (package
     (name "r-flowclust")
-    (version "3.36.0")
+    (version "3.36.1")
     (source
      (origin
        (method url-fetch)
        (uri (bioconductor-uri "flowClust" version))
        (sha256
         (base32
-         "1l1lfgm6x06gyzda36m6gvqmb91zbrz8m83b1fnfzpxkhqha20yq"))))
+         "1r27nm5dxlhl5rk96dkjfx8326bvdgx55xg4w2zji3m49x9db2gs"))))
     (properties `((upstream-name . "flowClust")))
     (build-system r-build-system)
     (arguments
@@ -19518,14 +20017,14 @@ using aCGH or sequencing.")
 (define-public r-bionero
   (package
     (name "r-bionero")
-    (version "1.6.0")
+    (version "1.6.1")
     (source
      (origin
        (method url-fetch)
        (uri (bioconductor-uri "BioNERO" version))
        (sha256
         (base32
-         "10nwgp8a9chn33p5k7cdp920rraiw187xfrylyd9bq010c7vp7xh"))))
+         "0ijdnl43cgzywgsz80jd6q0irixh6367qm1ll5ww1rcr4xas2nsl"))))
     (properties `((upstream-name . "BioNERO")))
     (build-system r-build-system)
     (propagated-inputs
diff --git a/gnu/packages/bioinformatics.scm b/gnu/packages/bioinformatics.scm
index fda01e00ca..f7adca0860 100644
--- a/gnu/packages/bioinformatics.scm
+++ b/gnu/packages/bioinformatics.scm
@@ -13991,6 +13991,85 @@ cells with similar identification cards in the different cytometric profiles
 is then merged.")
       (license license:gpl2))))
 
+(define-public r-cytoexplorer
+  (let ((commit "0efb1cc19fc701ae03905cf1b8484c1dfeb387df")
+        (revision "1"))
+    (package
+      (name "r-cytoexplorer")
+      (version (git-version "1.1.0" revision commit))
+      (source
+       (origin
+         (method git-fetch)
+         (uri (git-reference
+               (url "https://github.com/DillonHammill/CytoExploreR")
+               (commit commit)))
+         (file-name (git-file-name name version))
+         (sha256
+          (base32
+           "1y7dadsy15i47rjmdq6ns80jzm6p0zmixll37q68ba2c7xn5pq3v"))
+         (snippet
+          '(delete-file
+            "docs/articles/CytoExploreR_files/vis-4.20.1/vis.min.js"))))
+      (properties `((upstream-name . "CytoExploreR")))
+      (build-system r-build-system)
+      (arguments
+       (list
+        #:phases
+        '(modify-phases %standard-phases
+           (add-after 'unpack 'process-javascript
+             (lambda* (#:key inputs #:allow-other-keys)
+               (with-directory-excursion "docs/articles/CytoExploreR_files/"
+                 (let ((source (search-input-file inputs "/dist/vis.js"))
+                       (target "vis-4.20.1/vis.min.js"))
+                   (invoke "esbuild" source "--minify"
+                           (string-append "--outfile=" target)))))))))
+      (propagated-inputs
+       (list r-biocgenerics
+             r-bslib
+             r-data-table
+             r-dplyr
+             r-embedsom
+             r-flowai
+             r-flowcore
+             r-flowworkspace
+             r-gtools
+             r-magrittr
+             r-mass
+             r-opencyto
+             r-purrr
+             r-rhandsontable
+             r-robustbase
+             r-rsvd
+             r-rtsne
+             r-shiny
+             r-superheat
+             r-tibble
+             r-tidyr
+             r-umap
+             r-visnetwork))
+      (native-inputs
+       `(("esbuild" ,esbuild)
+         ("r-knitr" ,r-knitr)
+         ("js-vis"
+          ,(let ((version "4.20.1"))
+             (origin
+               (method git-fetch)
+               (uri (git-reference
+                     (url "https://github.com/almende/vis")
+                     (commit (string-append "v" version))))
+               (file-name (git-file-name "js-vis" version))
+               (sha256
+                (base32
+                 "09ldcqzzki5c0jlwas5992qjffqxnx6j5sl703qccfw7rg1hn469")))))))
+      (home-page "https://github.com/DillonHammill/CytoExploreR")
+      (synopsis "Interactive analysis of cytometry data")
+      (description
+       "This package has been developed under ROpenSci gudelines to integrate
+conventional and cutting edge cytometry analysis tools under a unified
+framework.  It aims to represent an intuitive and interactive approach to
+analysing cytometry data in R.")
+      (license license:gpl2))))
+
 (define-public r-giotto
   (let ((commit "3c8067cedbf6e3112edcac2ae796de05fd9d6fe4")
         (revision "1"))
@@ -14049,6 +14128,60 @@ is then merged.")
 spatial single-cell expression data.")
       (license license:expat))))
 
+(define-public r-illuminahumanmethylationepicanno-ilm10b5-hg38
+  (let ((commit "3db06910e27f626e0cc8b335ff45cf9a4050a36a")
+        (revision "1"))
+    (package
+      (name "r-illuminahumanmethylationepicanno-ilm10b5-hg38")
+      (version (git-version "0.0.1" revision commit))
+      (source (origin
+                (method git-fetch)
+                (uri (git-reference
+                      (url
+                       "https://github.com/achilleasNP/IlluminaHumanMethylationEPICanno.ilm10b5.hg38")
+                      (commit commit)))
+                (file-name (git-file-name name version))
+                (sha256
+                 (base32
+                  "0y8fhiwmkldi57f8nq64njfgljw68cm6pb1vh44hjwcc12k48sqr"))))
+      (properties `((upstream-name . "IlluminaHumanMethylationEPICanno.ilm10b5.hg38")))
+      (build-system r-build-system)
+      (propagated-inputs (list r-minfi))
+      (home-page
+       "https://github.com/achilleasNP/IlluminaHumanMethylationEPICanno.ilm10b5.hg38")
+      (synopsis "Illumina Human Methylation EPIC Annotation version 1.0B5")
+      (description
+       "This package provides a companion annotation file to the
+@code{IlluminaHumanMethylationEPICmanifest} package based on the same
+annotation 1.0B5.")
+      (license license:artistic2.0))))
+
+(define-public r-maxprobes
+  (let ((commit "c2120dba972e12115280ef274ff80550cee5b264")
+        (revision "1"))
+    (package
+      (name "r-maxprobes")
+      (version (git-version "0.0.2" revision commit))
+      (source (origin
+                (method git-fetch)
+                (uri (git-reference
+                      (url "https://github.com/markgene/maxprobes")
+                      (commit commit)))
+                (file-name (git-file-name name version))
+                (sha256
+                 (base32
+                  "1kij9bds2l9mwm519bzyd2608563qjlmbrayhva1s0vgml5iq9wh"))))
+      (properties `((upstream-name . "maxprobes")))
+      (build-system r-build-system)
+      (propagated-inputs (list r-minfi r-minfidata))
+      (native-inputs (list r-knitr))
+      (home-page "https://github.com/markgene/maxprobes")
+      (synopsis "Methylation array cross-reactive probes")
+      (description
+       "The Maxprobes package collects cross-reactive probes of Illumina
+methylation array 450K and EPIC/850K.")
+      (license license:gpl2+))))
+
 (define-public gffread
   ;; We cannot use the tagged release because it is not in sync with gclib.
   ;; See https://github.com/gpertea/gffread/issues/26
diff --git a/gnu/packages/check.scm b/gnu/packages/check.scm
index cfa604127b..631aac7db7 100644
--- a/gnu/packages/check.scm
+++ b/gnu/packages/check.scm
@@ -1322,11 +1322,14 @@ and many external plugins.")
          "0f8c31v5r2kgjixvy267n0nhc4xsy65g3n9lz1i1377z5pn5ydjg"))))
     (arguments
      (substitute-keyword-arguments (package-arguments python-pytest)
-      ((#:phases phases #~%standard-phases)
+       ((#:phases phases #~%standard-phases)
         #~(modify-phases #$phases
             (add-before 'build 'pretend-version
               (lambda _
-                (setenv "SETUPTOOLS_SCM_PRETEND_VERSION" #$version)))))))))
+                (setenv "SETUPTOOLS_SCM_PRETEND_VERSION" #$version)))))))
+    (propagated-inputs
+     (modify-inputs (package-propagated-inputs python-pytest)
+       (replace "python-pluggy" python-pluggy-next)))))
 
 (define-public python-pytest-bootstrap
   (package
diff --git a/gnu/packages/cran.scm b/gnu/packages/cran.scm
index e88d893517..f2bdd750ca 100644
--- a/gnu/packages/cran.scm
+++ b/gnu/packages/cran.scm
@@ -428,14 +428,14 @@ etc.")
 (define-public r-datawizard
   (package
     (name "r-datawizard")
-    (version "0.6.5")
+    (version "0.7.0")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "datawizard" version))
        (sha256
         (base32
-         "0il98vmy8l4wrisqz9xli7iki2ajdlsxyhh4k4grrd28gzkj8lgb"))))
+         "19bihl1nxd11gxwz3m71dprs3ykwp96pz24b38w6i6azin82apy0"))))
     (properties `((upstream-name . "datawizard")))
     (build-system r-build-system)
     (propagated-inputs
@@ -592,6 +592,35 @@ edition of the book \"Data Mining with R, learning with case studies\"
 by Luis Torgo, published by CRC Press.")
     (license license:gpl2+)))
 
+(define-public r-embedsom
+  (package
+    (name "r-embedsom")
+    (version "2.1.2")
+    (source (origin
+              (method url-fetch)
+              (uri (cran-uri "EmbedSOM" version))
+              (sha256
+               (base32
+                "0k4hja5y7qd0n3gfaxzxrz4wpxc1w9d4d4xbb63rq2nfk3lj7a42"))))
+    (properties `((upstream-name . "EmbedSOM")))
+    (build-system r-build-system)
+    (propagated-inputs
+     (list r-fnn
+           r-ggplot2
+           r-igraph
+           r-matrix
+           r-rtsne
+           r-umap
+           r-uwot))
+    (native-inputs (list r-knitr))
+    (home-page "https://github.com/exaexa/EmbedSOM")
+    (synopsis "Fast embedding guided by self-organizing map")
+    (description
+     "This package provides a smooth mapping of multidimensional points into
+low-dimensional space defined by a self-organizing map.  It is designed to
+work with FlowSOM and flow-cytometry use-cases.")
+    (license license:gpl3+)))
+
 (define-public r-emdist
   (package
     (name "r-emdist")
@@ -708,14 +737,14 @@ such as counts or binary matrices.")
 (define-public r-googledrive
   (package
     (name "r-googledrive")
-    (version "2.0.0")
+    (version "2.1.0")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "googledrive" version))
        (sha256
         (base32
-         "09jsiknzyfgxd0nzdr3wrrjw24allch2x74h96qg8vh8dad4cp30"))))
+         "0x2biilbphh77p7cxp2cvinjx45hnb5xksw775nwksqvpwxkaw0d"))))
     (properties `((upstream-name . "googledrive")))
     (build-system r-build-system)
     (propagated-inputs
@@ -943,14 +972,14 @@ pronounceable identifiers.")
 (define-public r-googlesheets4
   (package
     (name "r-googlesheets4")
-    (version "1.0.1")
+    (version "1.1.0")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "googlesheets4" version))
        (sha256
         (base32
-         "14b5lzn6vjn72mw7vf3lzm2ppbjf0wr0n6sw0v5r6h4lk37cnki8"))))
+         "1jcfih6f62phj7fdvknkkj46s9cvsnhshvkglg6xif7mpr1mbqah"))))
     (properties `((upstream-name . "googlesheets4")))
     (build-system r-build-system)
     (propagated-inputs
@@ -962,12 +991,14 @@ pronounceable identifiers.")
            r-googledrive
            r-httr
            r-ids
+           r-lifecycle
            r-magrittr
            r-purrr
            r-rematch2
            r-rlang
            r-tibble
-           r-vctrs))
+           r-vctrs
+           r-withr))
     (home-page "https://github.com/tidyverse/googlesheets4")
     (synopsis "Access Google Sheets using the Sheets API V4")
     (description
@@ -996,6 +1027,71 @@ matrix decomposition, sparse principal components analysis, and sparse
 canonical correlation analysis.")
     (license license:gpl2+)))
 
+(define-public r-prettydoc
+  (package
+    (name "r-prettydoc")
+    (version "0.4.1")
+    (source (origin
+              (method url-fetch)
+              (uri (cran-uri "prettydoc" version))
+              (sha256
+               (base32
+                "0aa89jnqhz0l69inrgm1f1riq5bm3ksb8wjl8d4x2f320adsd50h"))
+              (snippet
+               '(for-each delete-file
+                          '("inst/resources/js/auto-render.min.js"
+                            "inst/resources/js/katex.min.js")))))
+    (properties `((upstream-name . "prettydoc")))
+    (build-system r-build-system)
+    (arguments
+     `(#:modules ((guix build utils)
+                  (guix build r-build-system)
+                  (srfi srfi-1))
+       #:phases
+       (modify-phases %standard-phases
+         (add-after 'unpack 'process-javascript
+           (lambda* (#:key inputs #:allow-other-keys)
+             (with-directory-excursion "inst/resources/js/"
+               (call-with-values
+                   (lambda ()
+                     (unzip2
+                      `((,(search-input-file inputs "dist/katex.js")
+                         "katex.min.js")
+                        (,(search-input-file inputs "dist/contrib/auto-render.js")
+                         "auto-render.min.js"))))
+                 (lambda (sources targets)
+                   (for-each (lambda (source target)
+                               (format #true "Processing ~a --> ~a~%"
+                                       source target)
+                               (invoke "esbuild" source "--minify"
+                                       (string-append "--outfile=" target)))
+                             sources targets)))))))))
+    (inputs (list pandoc))
+    (propagated-inputs (list r-rmarkdown))
+    (native-inputs
+     (list esbuild
+           r-knitr
+           r-rmarkdown
+           (let ((version "0.12.0"))
+             (origin
+               (method git-fetch)
+               (uri (git-reference
+                     (url "https://github.com/KaTeX/KaTeX")
+                     (commit (string-append "v" version))))
+               (file-name (git-file-name "js-katex" version))
+               (sha256
+                (base32
+                 "0pdfw28affnfpqpnf244acf5rkxdy2gk63669myy7ysg4z0i1n8j"))))))
+    (home-page "https://github.com/yixuan/prettydoc")
+    (synopsis "Create pretty documents from R markdown")
+    (description
+     "This is a package for creating tiny yet beautiful documents and
+vignettes from R Markdown.  The package provides the @code{html_pretty} output
+format as an alternative to the @code{html_document} and @code{html_vignette}
+engines that convert R Markdown into HTML pages.  Various themes and syntax
+highlight styles are supported.")
+    (license license:asl2.0)))
+
 (define-public r-proj4
   (package
     (name "r-proj4")
@@ -1046,6 +1142,33 @@ Functions include searching for people, searching by DOI, or searching by
 Orcid ID.")
     (license license:expat)))
 
+(define-public r-ruv
+  (package
+    (name "r-ruv")
+    (version "0.9.7.1")
+    (source (origin
+              (method url-fetch)
+              (uri (cran-uri "ruv" version))
+              (sha256
+               (base32
+                "1n4q9mrp9f644spbns6bbnzmlabrg90hwkdfg3hnm3rxp9b4xid0"))))
+    (properties `((upstream-name . "ruv")))
+    (build-system r-build-system)
+    (propagated-inputs (list r-ggplot2 r-gridextra r-scales))
+    (home-page "https://cran.r-project.org/web/packages/ruv/index.html")
+    (synopsis "Detect and remove unwanted variation using negative controls")
+    (description
+     "This package implements the RUV (Remove Unwanted Variation) algorithms.
+These algorithms attempt to adjust for systematic errors of unknown origin in
+high-dimensional data.  The algorithms were originally developed for use with
+genomic data, especially microarray data, but may be useful with other types
+of high-dimensional data as well.  The algorithms require the user to specify
+a set of negative control variables, as described in the references.  The
+algorithms included in this package are RUV-2, RUV-4, RUV-inv, RUV-rinv,
+RUV-I, and RUV-III, along with various supporting algorithms.")
+    ;; Any version of the GPL.
+    (license (list license:gpl2+ license:gpl3+))))
+
 (define-public r-waldo
   (package
     (name "r-waldo")
@@ -3075,14 +3198,14 @@ model fitting and error handling.")
 (define-public r-modelr
   (package
     (name "r-modelr")
-    (version "0.1.10")
+    (version "0.1.11")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "modelr" version))
        (sha256
         (base32
-         "0qqgdb7gpb1h9lf5zijg51gd0qmbzj8f37aykhv1w633cglacick"))))
+         "1lvv6gac3g4x1d58chbvlxlkd77qz21a3rlb64jvzwycx43dbswl"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-broom
@@ -3246,6 +3369,29 @@ re-imagining of @code{httr} that uses a pipe-based interface and solves more
 of the problems that API wrapping packages face.")
     (license license:expat)))
 
+(define-public r-jade
+  (package
+    (name "r-jade")
+    (version "2.0-3")
+    (source (origin
+              (method url-fetch)
+              (uri (cran-uri "JADE" version))
+              (sha256
+               (base32
+                "1fj2wawx5ac1fvlp28naqha0i17f1sb47j2qqzgccvx17ycqmmjn"))))
+    (properties `((upstream-name . "JADE")))
+    (build-system r-build-system)
+    (propagated-inputs (list r-clue))
+    (home-page "https://cran.r-project.org/package=JADE")
+    (synopsis "Blind source separation methods")
+    (description
+     "In this package Cardoso's JADE algorithm as well as his functions for
+joint diagonalization are ported to R.  Also several other @dfn{blind source
+separation} (BSS) methods, like AMUSE and SOBI, and some criteria for
+performance evaluation of BSS algorithms, are given.  The package is described
+in Miettinen, Nordhausen and Taskinen (2017) <doi:10.18637/jss.v076.i02>.")
+    (license license:gpl2+)))
+
 (define-public r-jsonify
   (package
     (name "r-jsonify")
@@ -3341,13 +3487,13 @@ a list of p-values.")
 (define-public r-htmltools
   (package
     (name "r-htmltools")
-    (version "0.5.4")
+    (version "0.5.5")
     (source (origin
               (method url-fetch)
               (uri (cran-uri "htmltools" version))
               (sha256
                (base32
-                "0zij9zrgsi82q5c65sf4pbidnzrkfr763g0n4ypdhf8dd6l2i0h0"))))
+                "0nb6y99ffgj482clgnqbkhraxigr1ynpqv3d1znwd2ashnmkzcn8"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-base64enc r-digest r-ellipsis r-fastmap r-rlang))
@@ -4478,14 +4624,14 @@ contained in the navigation bar.")
 (define-public r-spelling
   (package
     (name "r-spelling")
-    (version "2.2")
+    (version "2.2.1")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "spelling" version))
        (sha256
         (base32
-         "179nj9w1v27qq9q5240ddvggp0795998sxyqjvbqjvq9dmach3bl"))))
+         "0vr5mgw9grnsnzsc29al72p05z786hnd6b9c6wq0c0dabk5szm2g"))))
     (properties `((upstream-name . "spelling")))
     (build-system r-build-system)
     (propagated-inputs
@@ -5119,13 +5265,13 @@ print, summary, plot, update, etc.
 (define-public r-ps
   (package
     (name "r-ps")
-    (version "1.7.2")
+    (version "1.7.3")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "ps" version))
        (sha256
-        (base32 "06mjwsn074195vd4yv7zzkmcf3sc124cw0cbnddj86swvggfn9cj"))))
+        (base32 "15wnn0wi253d3pmz0d98l4i6cn59d1h229g8valhh5arabn45b1v"))))
     (build-system r-build-system)
     (home-page "https://ps.r-lib.org")
     (synopsis "List, query, and manipulate system processes")
@@ -5523,13 +5669,13 @@ multi-dimensional data.")
 (define-public r-ctrdata
   (package
     (name "r-ctrdata")
-    (version "1.11.1")
+    (version "1.12.1")
     (source (origin
               (method url-fetch)
               (uri (cran-uri "ctrdata" version))
               (sha256
                (base32
-                "076v3bll8s6m61wcbwgrgrm34g0wa7gsc90mbwxwap1xfxyzjjsg"))))
+                "1m12vjwvzrwwb4d513vk171r25ww92qqv7rd2c3srmwzfi9ngy74"))))
     (properties `((upstream-name . "ctrdata")))
     (build-system r-build-system)
     (propagated-inputs
@@ -5537,6 +5683,7 @@ multi-dimensional data.")
            r-curl
            r-dplyr
            r-httr
+           r-jqr
            r-jsonlite
            r-lubridate
            r-nodbi
@@ -5672,14 +5819,14 @@ rows, dropping names) to see if the modified versions are identical.")
 (define-public r-dendextend
   (package
     (name "r-dendextend")
-    (version "1.16.0")
+    (version "1.17.1")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "dendextend" version))
        (sha256
         (base32
-         "0rl4f0b73s1gdjfxgpnz87lhv131qazxb6vsv2935ad266fd0bzc"))))
+         "08g5z5qyrn2nkw1jw5520sval4jf9l6invqwvzsv8dkjkq8nxsc7"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-ggplot2 r-magrittr r-viridis))
@@ -6631,6 +6778,26 @@ hypergeometric distributions.  In addition two random number generators of
 George Marsaglia are included.")
     (license license:gpl2+)))
 
+(define-public r-kpmt
+  (package
+    (name "r-kpmt")
+    (version "0.1.0")
+    (source (origin
+              (method url-fetch)
+              (uri (cran-uri "kpmt" version))
+              (sha256
+               (base32
+                "15d26khc0v3kc1c7l1avqp48pfqmc6xj32029mv7myivr41ashk3"))))
+    (properties `((upstream-name . "kpmt")))
+    (build-system r-build-system)
+    (propagated-inputs (list r-matrixstats))
+    (home-page "https://cran.r-project.org/package=kpmt")
+    (synopsis "Known population median test")
+    (description
+     "This package provides functions that implement the known population
+median test.")
+    (license license:expat)))
+
 (define-public r-ksamples
   (package
     (name "r-ksamples")
@@ -6985,6 +7152,28 @@ is being phased out.  A modern MySQL client based on Rcpp is available from
 the RMariaDB package.")
     (license license:gpl2)))
 
+(define-public r-rpmm
+  (package
+    (name "r-rpmm")
+    (version "1.25")
+    (source (origin
+              (method url-fetch)
+              (uri (cran-uri "RPMM" version))
+              (sha256
+               (base32
+                "1j48dh434wfhfzka0l21w6f73qlwfm70r9gdddhn504i2d5m4jph"))))
+    (properties `((upstream-name . "RPMM")))
+    (build-system r-build-system)
+    (propagated-inputs (list r-cluster))
+    (home-page "https://cran.r-project.org/package=RPMM")
+    (synopsis "Recursively partitioned mixture model")
+    (description
+     "This package provides a recursively partitioned mixture model for Beta
+and Gaussian mixtures.  This is a model-based clustering algorithm that
+returns a hierarchy of classes, similar to hierarchical clustering, but also
+similar to finite mixture models.")
+    (license license:gpl2+)))
+
 (define-public r-rpostgresql
   (package
     (name "r-rpostgresql")
@@ -7611,14 +7800,14 @@ Laplace approximation and adaptive Gauss-Hermite quadrature.")
 (define-public r-jomo
   (package
     (name "r-jomo")
-    (version "2.7-4")
+    (version "2.7-5")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "jomo" version))
        (sha256
         (base32
-         "1zck7p872k080hyfs0hibq7v13zmsry1jdlnq7k33ff1iljbq99d"))))
+         "05xfkj65nqd987pp5bhl4jy46qxwjll5mxnjii6qrmfmjld177q5"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-lme4 r-mass r-ordinal r-survival r-tibble))
@@ -7814,13 +8003,13 @@ and density estimation")
 (define-public r-smurf
   (package
     (name "r-smurf")
-    (version "1.1.4")
+    (version "1.1.5")
     (source (origin
               (method url-fetch)
               (uri (cran-uri "smurf" version))
               (sha256
                (base32
-                "09a56ayqnnal1h5xxnh4pcn0zyi1kg2fj40y872n4jcnbl8xcvbi"))))
+                "1gpzzj67x0i70vw1x4rv56mhk2b74ynvdsy93rzmdk6b2h3dvv46"))))
     (properties `((upstream-name . "smurf")))
     (build-system r-build-system)
     (propagated-inputs
@@ -7831,8 +8020,7 @@ and density estimation")
            r-mgcv
            r-rcolorbrewer
            r-rcpp
-           r-rcpparmadillo
-           r-speedglm))
+           r-rcpparmadillo))
     (native-inputs (list r-knitr))
     (home-page "https://gitlab.com/TReynkens/smurf")
     (synopsis "Sparse multi-type regularized feature modeling")
@@ -8230,14 +8418,14 @@ multivariate function estimation using smoothing splines.")
 (define-public r-cli
   (package
     (name "r-cli")
-    (version "3.6.0")
+    (version "3.6.1")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "cli" version))
        (sha256
         (base32
-         "15mqi8cacj7x588f1a7x805lwqbga2ha62k79qyxahrhh0qq21xn"))))
+         "0djyl08k7nhlbzgnfx7gq8w00s7c9f66bd11bvi9lzz6qz70cc5y"))))
     (build-system r-build-system)
     (home-page "https://github.com/r-lib/cli#readme")
     (synopsis "Helpers for developing command line interfaces")
@@ -8504,13 +8692,13 @@ iVAT).")
 (define-public r-xfun
   (package
     (name "r-xfun")
-    (version "0.37")
+    (version "0.38")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "xfun" version))
        (sha256
-        (base32 "1yg1b21nwpnggb498z0j3lp11w6fwni7q7rd88fnm8xfnbq9yq9v"))))
+        (base32 "12n60c18rgg65qxnlp4sv6q9zryiz146844ayd28kipnjpwc4457"))))
     (build-system r-build-system)
     ;; knitr itself depends on xfun
     #;
@@ -8591,14 +8779,14 @@ estimated from a given sample.")
 (define-public r-vctrs
   (package
     (name "r-vctrs")
-    (version "0.6.0")
+    (version "0.6.1")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "vctrs" version))
        (sha256
         (base32
-         "0mwp56s87bdrg5xr4mnjr0qrdsq18dmfs3d640qkbbka9qn722xy"))))
+         "10qjirgdq0bn2s84vqx5c78i85mdp5mxwdfn30kayh3wpmij8mbp"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-cli r-glue r-lifecycle r-rlang))
@@ -8630,14 +8818,14 @@ estimated from a given sample.")
 (define-public r-pillar
   (package
     (name "r-pillar")
-    (version "1.8.1")
+    (version "1.9.0")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "pillar" version))
        (sha256
         (base32
-         "1v47dm2v4nlswd1gmgcx5c7yrgn1ksdfr9lqkc63jf2nkv6af1ig"))))
+         "1k3sp37dpn46d2xbq621alpvzgnm06x5qb87nk169y47q23b8gpj"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-cli
@@ -9549,14 +9737,14 @@ interface.")
 (define-public r-trend
   (package
     (name "r-trend")
-    (version "1.1.4")
+    (version "1.1.5")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "trend" version))
        (sha256
         (base32
-         "1mr5g5gaxiqj6x83ngcbwwh57vhrhcz0x9dh0rmvs9y2ivk29ccs"))))
+         "12xswr925jjbkdccjiigkr6a44jmgvzwvnizciv6rr3mnklv6n66"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-extradistr))
@@ -10170,13 +10358,13 @@ It also includes interpolation functions.")
 (define-public r-simplermarkdown
   (package
     (name "r-simplermarkdown")
-    (version "0.0.4")
+    (version "0.0.6")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "simplermarkdown" version))
        (sha256
-        (base32 "069pgx5m22rdqa21lyn5zqm9ym3g7w6z1d2wjwms8b1f2cp6266g"))))
+        (base32 "0lffwsrhsdqcqhklh24v0y0x6w4vq9jch93m330kfdv2amab1l06"))))
     (properties `((upstream-name . "simplermarkdown")))
     (build-system r-build-system)
     (propagated-inputs
@@ -10552,14 +10740,14 @@ used.")
 (define-public r-arules
   (package
     (name "r-arules")
-    (version "1.7-5")
+    (version "1.7-6")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "arules" version))
        (sha256
         (base32
-         "0d04w28hl9gcrvkj0v0q77x4a89jhvzf1imw58xfgncap8mc6555"))))
+         "0syrbh85vzhp9plm95dhq6pfanzbxqm4wcahw3y2d26gvi2nmzwm"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-generics r-matrix))
@@ -11028,19 +11216,18 @@ finance, conversion from and to JSON, and many other applications.")
 (define-public r-dtplyr
   (package
     (name "r-dtplyr")
-    (version "1.3.0")
+    (version "1.3.1")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "dtplyr" version))
        (sha256
         (base32
-         "1y40yrfdw1wbx7jqmql69yi3q52lzjpqgr4jwnhjr33hw6kxvg0v"))))
+         "1rfnr1f3dzzivzmw9jjaclckkany6c625bqr8lkx32qbcjd6iad5"))))
     (properties `((upstream-name . "dtplyr")))
     (build-system r-build-system)
     (propagated-inputs
      (list r-cli
-           r-crayon
            r-data-table
            r-dplyr
            r-glue
@@ -11606,14 +11793,14 @@ publication-ready plots.")
 (define-public r-ellipse
   (package
     (name "r-ellipse")
-    (version "0.4.3")
+    (version "0.4.4")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "ellipse" version))
        (sha256
         (base32
-         "0im9d36dixpksms52v6nsb3l0z2c7wc25r9j0f08naj6qc8jpvq2"))))
+         "1r4srqgpzh4r0cryc74gjcfwj0j54ibzh325bi31aa9dwi9dw03z"))))
     (build-system r-build-system)
     (home-page "https://cran.r-project.org/web/packages/ellipse/")
     (synopsis "Functions for drawing ellipses and ellipse-like confidence regions")
@@ -11650,14 +11837,14 @@ clustering.")
 (define-public r-factominer
   (package
     (name "r-factominer")
-    (version "2.7")
+    (version "2.8")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "FactoMineR" version))
        (sha256
         (base32
-         "03952kcnwrm61kn5im55ky1j91nm5x4i4f5gs115li6gck63xf17"))))
+         "0lgqbw7534wadkdv7zh1y5nanl72jys070qydznmaj2cmvvqd460"))))
     (properties `((upstream-name . "FactoMineR")))
     (build-system r-build-system)
     (propagated-inputs
@@ -11995,14 +12182,14 @@ references and Rd files.")
 (define-public r-officer
   (package
     (name "r-officer")
-    (version "0.6.1")
+    (version "0.6.2")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "officer" version))
        (sha256
         (base32
-         "19sn36aaxr2bmxm8lrs1vqmc4fc1gfwarp418pn09jk105ckykh8"))))
+         "0dfk1didy5lfh07chqfwlrdlrib7a5na65rb71ipnxlhbiwbaj09"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-openssl r-r6 r-ragg r-uuid r-xml2 r-zip))
@@ -12317,13 +12504,13 @@ tidyverse workflow.")
 (define-public r-nodbi
   (package
     (name "r-nodbi")
-    (version "0.9.1")
+    (version "0.9.2")
     (source (origin
               (method url-fetch)
               (uri (cran-uri "nodbi" version))
               (sha256
                (base32
-                "1hn0wy2ry9l3wwqrshmf82cxigkm16wycwprv458bcvb5k6ayy5m"))))
+                "167zhlyl0crn24zyw9rz9spa5xh8nxpzl94vqsk02r849n4qvzx9"))))
     (properties `((upstream-name . "nodbi")))
     (build-system r-build-system)
     (propagated-inputs
@@ -13189,13 +13376,13 @@ ABC algorithms.")
 (define-public r-abctools
   (package
     (name "r-abctools")
-    (version "1.1.4")
+    (version "1.1.6")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "abctools" version))
        (sha256
-        (base32 "02c473fqj7yd27flma2x7flqzqbrnba2xfcjy466nww0sm1vvhjg"))))
+        (base32 "0yxmj28ym8919l27m04yjyc7mya1iy5ap4p980grsh7m4cgpx3bh"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-abc r-abind r-hmisc r-plyr))
@@ -13283,14 +13470,14 @@ repeated measures data, respectively.")
 (define-public r-gam
   (package
     (name "r-gam")
-    (version "1.22-1")
+    (version "1.22-2")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "gam" version))
        (sha256
         (base32
-         "1h84klxs7wbksn9hsqdspmska9q5pmy6q71fmwm4bcmdrqixr8gv"))))
+         "1yh2rahcbi2fbsi1yps1l51xxljc7lcs7h729y5vjj4l492pywzy"))))
     (properties `((upstream-name . "gam")))
     (build-system r-build-system)
     (propagated-inputs
@@ -13358,14 +13545,14 @@ both to consistency and asymptotic normality.")
 (define-public r-dofuture
   (package
     (name "r-dofuture")
-    (version "0.12.2")
+    (version "1.0.0")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "doFuture" version))
        (sha256
         (base32
-         "0w07pmzpsfq4kvfc745s1i9b6dfn1df1wrfi4s9ys4ir3g2s8nk1"))))
+         "1pxwpfmxswbsd1f2ifj9kdq9hi9q0x2wwv2kv0xq178ymmywi2sz"))))
     (properties `((upstream-name . "doFuture")))
     (build-system r-build-system)
     (arguments
@@ -13374,7 +13561,7 @@ both to consistency and asymptotic normality.")
          (add-after 'unpack 'set-HOME
            (lambda _ (setenv "HOME" "/tmp"))))))
     (propagated-inputs
-     (list r-foreach r-future r-globals r-iterators))
+     (list r-foreach r-future r-future-apply r-globals r-iterators))
     (native-inputs
      (list r-r-rsp)) ; vignette builder
     (home-page "https://github.com/HenrikBengtsson/doFuture")
@@ -14754,14 +14941,14 @@ Bayesian modeling.")
 (define-public r-tmb
   (package
     (name "r-tmb")
-    (version "1.9.2")
+    (version "1.9.3")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "TMB" version))
        (sha256
         (base32
-         "0kz5a3y6xcqz2ycxq6ff3jasc2hkvq2rxnpr618nng7k9gljc504"))))
+         "10cl88v3jdjv0sacfvk1g9y7sl918rxlyk9ddy2d1y7055j8y0qg"))))
     (properties `((upstream-name . "TMB")))
     (build-system r-build-system)
     (propagated-inputs
@@ -16009,22 +16196,39 @@ netCDF files.")
 Bioconductor packages.")
     (license license:artistic2.0)))
 
+;; TODO: one more minified JavaScript files is included that should be built
+;; from the included .src.js files, but it is not entirely clear how.  The
+;; file is inst/htmlwidgets/lib/rglClass/rglClass.min.js.
 (define-public r-rgl
   (package
     (name "r-rgl")
-    (version "1.0.1")
+    (version "1.1.3")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "rgl" version))
        (sha256
         (base32
-         "1j1g1b1j6azhg944ddzzrxgynb2bfl14l5qz58n4mhvxrbx018w9"))))
+         "1blasg60x38z57ds6x7yb4rvjx21yf4s99q93sl1w9h6mg14d8jg"))
+       (snippet
+        '(delete-file "inst/htmlwidgets/lib/CanvasMatrix/CanvasMatrix.min.js"))))
     (build-system r-build-system)
+    (arguments
+     (list
+      #:phases
+      '(modify-phases %standard-phases
+         (add-after 'unpack 'process-javascript
+           (lambda* (#:key inputs #:allow-other-keys)
+             (with-directory-excursion "inst/htmlwidgets/lib/"
+               (let ((source "CanvasMatrix/CanvasMatrix.src.js")
+                     (target "CanvasMatrix/CanvasMatrix.min.js"))
+                 (invoke "esbuild" source "--minify"
+                         (string-append "--outfile=" target)))))))))
     (native-inputs
-     (list pkg-config
+     (list esbuild
+           pkg-config
            r-knitr
-           r-rmarkdown)) ;for vignettes
+           r-rmarkdown))                ;for vignettes
     (inputs
      (list freetype
            libpng
@@ -16077,13 +16281,13 @@ to colexicographical order.")
 (define-public r-multidplyr
   (package
     (name "r-multidplyr")
-    (version "0.1.2")
+    (version "0.1.3")
     (source (origin
               (method url-fetch)
               (uri (cran-uri "multidplyr" version))
               (sha256
                (base32
-                "081x9n46dl6vpp5q6pilw3w5wpdi3r9kwi9n6h4k2p2iqg1s96lb"))))
+                "18yl24s1g8wf3xi6f0k7jhs99ka4dslxf5p9ax9m5l1rbva5xdwj"))))
     (properties `((upstream-name . "multidplyr")))
     (build-system r-build-system)
     (propagated-inputs
@@ -18972,14 +19176,14 @@ them in distributed compute environments.")
 (define-public r-parallelly
   (package
     (name "r-parallelly")
-    (version "1.34.0")
+    (version "1.35.0")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "parallelly" version))
        (sha256
         (base32
-         "1x5gk008813i9c2i7qdhpmlbq2xdgv5q47xcmc6lb8p475q9sqqi"))))
+         "1kaxmmkwjxnympxsyphwfdba6nmp4jszhrsy5h2snshr0xjrnpiz"))))
     (properties `((upstream-name . "parallelly")))
     (build-system r-build-system)
     (home-page "https://github.com/HenrikBengtsson/parallelly")
@@ -24342,15 +24546,48 @@ function and interfaces to external frameworks.")
 (define-public r-covr
   (package
     (name "r-covr")
-    (version "3.6.1")
+    (version "3.6.2")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "covr" version))
        (sha256
-        (base32 "0mqiqmbwq5f083lda208nqd4ya0f912bkkya2i62fkqsii1ibgpz"))))
+        (base32 "0ns8xbq1l21mg8p2aiqv5h306a3vpn64j6jrgzbv8iv1a7kqrrmc"))
+       (modules '((guix build utils)))
+       (snippet
+        '(with-directory-excursion "inst/www/shared"
+           (for-each delete-file
+                     '("bootstrap/js/bootstrap.min.js"
+                       "bootstrap/shim/html5shiv.min.js"
+                       "bootstrap/shim/respond.min.js"))))))
     (properties `((upstream-name . "covr")))
     (build-system r-build-system)
+    (arguments
+     (list
+      #:modules '((guix build utils)
+                  (guix build r-build-system)
+                  (srfi srfi-1))
+      #:phases
+      #~(modify-phases %standard-phases
+          (add-after 'unpack 'process-javascript
+            (lambda* (#:key inputs #:allow-other-keys)
+              (with-directory-excursion "inst/www/shared"
+                (call-with-values
+                    (lambda ()
+                      (unzip2
+                       `((,(search-input-file inputs "/dist/js/bootstrap.js")
+                          "bootstrap/js/bootstrap.min.js")
+                         (,(search-input-file inputs "/dist/html5shiv.js")
+                          "bootstrap/shim/html5shiv.min.js")
+                         (,(search-input-file inputs "/dest/respond.src.js")
+                          "bootstrap/shim/respond.min.js"))))
+                  (lambda (sources targets)
+                    (for-each (lambda (source target)
+                                (format #true "Processing ~a --> ~a~%"
+                                        source target)
+                                (invoke "esbuild" source "--minify"
+                                        (string-append "--outfile=" target)))
+                              sources targets)))))))))
     (propagated-inputs
      (list r-crayon
            r-digest
@@ -24360,7 +24597,38 @@ function and interfaces to external frameworks.")
            r-withr
            r-yaml))
     (native-inputs
-     (list r-knitr)) ; for vignettes
+     (list esbuild
+           r-knitr  ;for vignettes
+           (let ((version "3.3.5"))
+             (origin
+               (method git-fetch)
+               (uri (git-reference
+                     (url "https://github.com/twbs/bootstrap")
+                     (commit (string-append "v" version))))
+               (file-name (git-file-name "js-bootstrap" version))
+               (sha256
+                (base32
+                 "1zxrjhnnd594rflnwzqhbx3rx0gjlh6hgx9v2nppgkmrkqb7y1a4"))))
+           (let ((version "3.7.2"))
+             (origin
+               (method git-fetch)
+               (uri (git-reference
+                     (url "https://github.com/aFarkas/html5shiv")
+                     (commit version)))
+               (file-name (git-file-name "js-html5shiv" version))
+               (sha256
+                (base32
+                 "0mw4bbl9a9d1ibywscjgmbky0jkj4081l1yd4x3ss0flwaa3fwsk"))))
+           (let ((version "1.4.2"))
+             (origin
+               (method git-fetch)
+               (uri (git-reference
+                     (url "https://github.com/scottjehl/Respond")
+                     (commit version)))
+               (file-name (git-file-name "js-respond" version))
+               (sha256
+                (base32
+                 "00xid731rirc7sdy1gc8qal3v9g0agr2qx15hm4x97l1lcbylyn2"))))))
     (home-page "https://github.com/r-lib/covr")
     (synopsis "Test coverage for R packages")
     (description
@@ -27212,14 +27480,14 @@ number embedded in the file rather than the file extension.")
 (define-public r-imager
   (package
     (name "r-imager")
-    (version "0.42.18")
+    (version "0.42.19")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "imager" version))
        (sha256
         (base32
-         "0ljkcvs91sjddndwdbaqg0nf9sksm0284s6kg05k027wnvbkc5f1"))))
+         "1qp1190cb7pssl22vakd8z8zvj6mmhrn7jk6wkjyrv28lv5vqyhq"))))
     (properties `((upstream-name . "imager")))
     (build-system r-build-system)
     (inputs
@@ -27272,14 +27540,14 @@ it may be seen by an animal with less acute vision.")
 (define-public r-caret
   (package
     (name "r-caret")
-    (version "6.0-93")
+    (version "6.0-94")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "caret" version))
        (sha256
         (base32
-         "01sa1h9pc3a062pwm0rxadvg9qxszwcylya7llv08fcxhy46n5ac"))))
+         "1a191n9qswvf8ri6id8picqgdqx15l6mp996v6f77fv0l8yfh597"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-e1071
@@ -29608,14 +29876,14 @@ using the @code{rstan} and @code{rstanarm} packages).")
 (define-public r-rstantools
   (package
     (name "r-rstantools")
-    (version "2.3.0")
+    (version "2.3.1")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "rstantools" version))
        (sha256
         (base32
-         "0bc22fxpw4xvdxx8716wbasw8rpkpipb428cv764s8c0mkk2szlk"))))
+         "0xb9rb6nlqsqxi08hx9iwqpfz6ssdmh6axyk7d399j7zhklg5m42"))))
     (properties `((upstream-name . "rstantools")))
     (build-system r-build-system)
     (inputs (list pandoc))
@@ -29817,14 +30085,14 @@ Additional storage back-ends can be added easily.")
 (define-public r-zyp
   (package
     (name "r-zyp")
-    (version "0.11")
+    (version "0.11-1")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "zyp" version))
        (sha256
         (base32
-         "0jmddxg88qb9f38ywdy4min7w5qadnkhqxd46b0j0gjsq95vw85q"))))
+         "0gqds43ivbsi4770nxj5sf4mp51m410svnap0v1rh8vlk3gkb3l9"))))
     (properties `((upstream-name . "zyp")))
     (build-system r-build-system)
     (propagated-inputs
@@ -29841,13 +30109,13 @@ climate data.")
 (define-public r-rlecuyer
   (package
     (name "r-rlecuyer")
-    (version "0.3-5")
+    (version "0.3-7")
     (source (origin
               (method url-fetch)
               (uri (cran-uri "rlecuyer" version))
               (sha256
                (base32
-                "09mniai7v8gapr6hd3zm8sm3vi1zcyhgym389904ykb2yx7l68s7"))))
+                "0g5z26wsbv3wzrc3gl1z97qxdk5m2pvfg3f5zqkz98wzh1z49b35"))))
     (properties `((upstream-name . "rlecuyer")))
     (build-system r-build-system)
     (home-page
@@ -30693,14 +30961,14 @@ vignette for more information and examples.")
 (define-public r-distributional
   (package
     (name "r-distributional")
-    (version "0.3.1")
+    (version "0.3.2")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "distributional" version))
        (sha256
         (base32
-         "0pr34yq6igb7ciqss2ldwa7gc55xvla040x8rkd8m2hcrz5mczkj"))))
+         "1y08s301mxz7c54lxa1j0zzbsrgphxv5hsyam3jswcw274rxd0y8"))))
     (properties
      `((upstream-name . "distributional")))
     (build-system r-build-system)
@@ -31027,18 +31295,18 @@ counting and recursive k-means partitioning.")
 (define-public r-hardhat
   (package
     (name "r-hardhat")
-    (version "1.2.0")
+    (version "1.3.0")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "hardhat" version))
        (sha256
         (base32
-         "0y5dxpd4gsrs365x1v4qf2vq7hq2qb6f6x50dyj29xmmn760wcpr"))))
+         "0bp83yw7j34iwir2f73ainic11cdz0q18m5v1kbx8vdsw84z17zy"))))
     (properties `((upstream-name . "hardhat")))
     (build-system r-build-system)
     (propagated-inputs
-     (list r-glue r-rlang r-tibble r-vctrs))
+     (list r-cli r-glue r-rlang r-tibble r-vctrs))
     (native-inputs
      (list r-knitr))
     (home-page "https://github.com/tidymodels/hardhat")
@@ -34256,13 +34524,13 @@ package also supersedes the package @code{BBmisc}.")
 (define-public r-mlr3pipelines
   (package
     (name "r-mlr3pipelines")
-    (version "0.4.2")
+    (version "0.4.3")
     (source (origin
               (method url-fetch)
               (uri (cran-uri "mlr3pipelines" version))
               (sha256
                (base32
-                "09pk3dwjcg5rbpwa1k21srdpvf2dlxq4b5p71cvkha85jx2gdgh6"))))
+                "1ycrm4i0k38mkw1r1a5sxp761wdz3p0q72xz6qqg3qsyva4ba0wz"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-backports
@@ -38068,13 +38336,13 @@ supports @command{sf} and @command{stars}.")
 (define-public r-automap
   (package
     (name "r-automap")
-    (version "1.1-1")
+    (version "1.1-9")
     (source (origin
               (method url-fetch)
               (uri (cran-uri "automap" version))
               (sha256
                (base32
-                "11l6iygq66jg11lilwjmf7l250dcvhilx6zv2lm746rjzchwga0s"))))
+                "0hrsdynjxv0n5n1pbdk05rgrcwfd0g5p9pgdbicx4ljk73nhl1zk"))))
     (properties `((upstream-name . "automap")))
     (build-system r-build-system)
     (propagated-inputs (list r-ggplot2
diff --git a/gnu/packages/databases.scm b/gnu/packages/databases.scm
index 3b8fefc122..d8c8499fdd 100644
--- a/gnu/packages/databases.scm
+++ b/gnu/packages/databases.scm
@@ -59,6 +59,7 @@
 ;;; Copyright © 2022 muradm <mail@muradm.net>
 ;;; Copyright © 2022 Thomas Albers Raviola <thomas@thomaslabs.org>
 ;;; Copyright © 2021, 2022 jgart <jgart@dismail.de>
+;;; Copyright © 2023 Felix Gruber <felgru@posteo.net>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -3573,6 +3574,79 @@ this library provides functions to facilitate such comparisons.")
 SQLAlchemy Database Toolkit for Python.")
     (license license:expat)))
 
+(define-public python-sqlite-fts4
+  (package
+    (name "python-sqlite-fts4")
+    (version "1.0.3")
+    (source (origin
+              (method url-fetch)
+              (uri (pypi-uri "sqlite-fts4" version))
+              (sha256
+               (base32
+                "034kx0ac556sywy1p4qcrc36l24w3q0xwswqv2z9s3k8yvm5xc3q"))))
+    (build-system python-build-system)
+    (native-inputs (list python-pytest))
+    (home-page "https://github.com/simonw/sqlite-fts4")
+    (synopsis "Python functions for working with SQLite FTS4 search")
+    (description "This package provides custom SQLite functions written
+in Python for ranking documents indexed using the SQLite's FTS4 full
+text search extension.")
+    (license license:asl2.0)))
+
+(define-public python-sqlite-utils
+  (package
+    (name "python-sqlite-utils")
+    (version "3.30")
+    (source (origin
+              (method git-fetch)        ;for tests
+              (uri (git-reference
+                    (url "https://github.com/simonw/sqlite-utils")
+                    (commit version)))
+              (file-name (git-file-name name version))
+              (sha256
+               (base32
+                "1a58syvh5jp40vi5libsxkqy99z75kj4ckxqmylbhd342ppfy1wp"))))
+    (build-system pyproject-build-system)
+    (arguments
+     (list #:phases #~(modify-phases %standard-phases
+                        (add-after 'unpack 'relax-requirements
+                          (lambda _
+                            (substitute* "setup.py"
+                              ;; This is a variant designed to have a binary
+                              ;; wheel made available on PyPI, which is not a
+                              ;; concern to Guix.
+                              (("click-default-group-wheel")
+                               "click-default-group")))))))
+    (propagated-inputs (list python-click python-click-default-group
+                             python-dateutil python-sqlite-fts4
+                             python-tabulate))
+    (native-inputs (list python-pytest))
+    (home-page "https://github.com/simonw/sqlite-utils")
+    (synopsis
+     "CLI tool and Python utility functions for manipulating SQLite databases")
+    (description
+     "This package provides a CLI tool and Python utility functions for
+manipulating SQLite databases.  It's main features are:
+@itemize
+@item
+Pipe JSON (or CSV or TSV) directly into a new SQLite database file,
+automatically creating a table with the appropriate schema.
+@item
+Run in-memory SQL queries, including joins, directly against data in
+CSV, TSV or JSON files and view the results.
+@item
+Configure SQLite full-text search against your database tables and run
+search queries against them, ordered by relevance.
+@item
+Run transformations against your tables to make schema changes that
+SQLite ALTER TABLE does not directly support, such as changing the type
+of a column.
+@item
+Extract columns into separate tables to better normalize your existing
+data.
+@end itemize")
+    (license license:asl2.0)))
+
 (define-public python-pickleshare
   (package
     (name "python-pickleshare")
@@ -5031,3 +5105,84 @@ generic interface to caching backends of any variety, and additionally
 provides API hooks which integrate these cache backends with the locking
 mechanism of @code{dogpile}.")
     (license license:expat)))
+
+(define-public datasette
+  (package
+    (name "datasette")
+    (version "0.64.2")
+    (source (origin
+              (method git-fetch)        ;for tests
+              (uri (git-reference
+                    (url "https://github.com/simonw/datasette")
+                    (commit version)))
+              (file-name (git-file-name name version))
+              (sha256
+               (base32
+                "1c8ajdaraynrjvsb8xxxnkb7zgm5fwq60qczaz00n465ki80j4h3"))))
+    (build-system pyproject-build-system)
+    (arguments
+     (list
+      #:test-flags
+      ;; There are multiple unexplained test failures (see:
+      ;; https://github.com/simonw/datasette/issues/2048).
+      #~(list "-k" (string-append
+                    "not (test_database_page_for_database_with_dot_in_name"
+                    " or test_row_strange_table_name"
+                    " or test_database_with_space_in_name"
+                    " or test_tilde_encoded_database_names"
+                    " or test_weird_database_names"
+                    " or test_css_classes_on_body"
+                    " or test_templates_considered"
+                    " or test_row_html_compound_primary_key"
+                    " or test_edit_sql_link_on_canned_queries"
+                    " or test_alternate_url_json"
+                    " or test_table_with_slashes_in_name"
+                    " or test_searchable"
+                    " or test_custom_query_with_unicode_characters"
+                    " or test_searchmode)")
+              "-n" (number->string (parallel-job-count))
+              "-m" "not serial")        ;cannot run in parallel
+      #:phases
+      #~(modify-phases %standard-phases
+          (add-after 'unpack 'relax-requirements
+            (lambda _
+              ;; The package needlessly specifies exact versions
+              ;; of dependencies, when it works fine with others.
+              (substitute* "setup.py"
+                (("(black)==[0-9\\.]+" _ package)
+                 package)
+                (("click-default-group-wheel")
+                 "click-default-group")))))))
+    (propagated-inputs
+     (list python-aiofiles
+           python-asgi-csrf
+           python-asgiref
+           python-click
+           python-click-default-group
+           python-httpx
+           python-hupper
+           python-itsdangerous
+           python-janus
+           python-jinja2
+           python-mergedeep
+           python-pint
+           python-pluggy-next
+           python-pyyaml
+           python-uvicorn))
+    (native-inputs
+     (list python-beautifulsoup4
+           python-black
+           python-cogapp
+           python-pytest-7.1
+           python-pytest-asyncio
+           python-pytest-runner
+           python-pytest-timeout
+           python-pytest-xdist-next
+           python-setuptools
+           python-trustme))
+    (home-page "https://datasette.io/")
+    (synopsis "Multi-tool for exploring and publishing data")
+    (description "Datasette is a tool for exploring and publishing data.
+It helps people take data of any shape or size and publish that as an
+interactive, explorable website and accompanying API.")
+    (license license:asl2.0)))
diff --git a/gnu/packages/emacs-xyz.scm b/gnu/packages/emacs-xyz.scm
index da2856abc8..de4a7f301a 100644
--- a/gnu/packages/emacs-xyz.scm
+++ b/gnu/packages/emacs-xyz.scm
@@ -49,7 +49,7 @@
 ;;; Copyright © 2019, 2020, 2021 Joseph LaFreniere <joseph@lafreniere.xyz>
 ;;; Copyright © 2019 Todor Kondić <tk.code@protonmail.com>15669
 ;;; Copyright © 2019 Amar Singh <nly@disroot.org>
-;;; Copyright © 2019, 2022 Baptiste Strazzulla <bstrazzull@hotmail.fr>
+;;; Copyright © 2019, 2022, 2023 Baptiste Strazzulla <bstrazzull@hotmail.fr>
 ;;; Copyright © 2019 Giacomo Leidi <goodoldpaul@autistici.org>
 ;;; Copyright © 2019 Jens Mølgaard <jens@zete.tk>
 ;;; Copyright © 2019, 2020 Amin Bandali <bandali@gnu.org>
@@ -2686,14 +2686,14 @@ project root.")
 (define-public emacs-relint
   (package
     (name "emacs-relint")
-    (version "1.21")
+    (version "1.22")
     (source
      (origin
        (method url-fetch)
        (uri (string-append "https://elpa.gnu.org/packages/"
                            "relint-" version ".tar"))
        (sha256
-        (base32 "12453agy7y3ayqn32fi11ljlnk8ck3i1aljw5wzm0yyqp00m73x3"))))
+        (base32 "1525hk961q4af06c5a60m7ryp5g8yvfxjp5nmmgkci7vl3ing8zi"))))
     (build-system emacs-build-system)
     (propagated-inputs (list emacs-xr))
     (home-page "https://github.com/mattiase/relint")
@@ -3894,7 +3894,7 @@ of bibliographic references.")
 (define-public emacs-corfu
   (package
     (name "emacs-corfu")
-    (version "0.35")
+    (version "0.36")
     (source
      (origin
        (method git-fetch)
@@ -3903,7 +3903,7 @@ of bibliographic references.")
              (commit version)))
        (file-name (git-file-name name version))
        (sha256
-        (base32 "1xqg796844wk6kvn3xw4bqlxn9ra6jlwk7rsc5gy4j77l0gwl441"))))
+        (base32 "02glwnny9b4pwhq5inrakfz03zrq0zq1vr4npv88yla6pg8v87xx"))))
     (build-system emacs-build-system)
     (arguments
      (list
@@ -5363,33 +5363,42 @@ environments.")
     (license license:gpl2+)))
 
 (define-public emacs-lemon
-  (let ((commit "37a6e6d6ef0900ca19c820a2dbc122c7fe6d86cf")
-        (revision "0"))
-    (package
-      (name "emacs-lemon")
-      (version (git-version "2.0.0" revision commit))
-      (source
-       (origin
-         (method git-fetch)
-         (uri (git-reference
-               (url "https://codeberg.org/emacs-weirdware/lemon")
-               (commit commit)))
-         (file-name (git-file-name name version))
-         (sha256
-          (base32 "0bc77vzi4p6mlzmhgybbldlpcsiiv4xqrd5lnc7wzvmxv8byhqpm"))))
-      (build-system emacs-build-system)
-      (native-inputs
-       (list emacs-blight emacs-emms))
-      (propagated-inputs
-       (list emacs-s))
-      (home-page "https://codeberg.org/emacs-weirdware/lemon")
-      (synopsis "System monitors in the echo area")
-      (description
-       "Lemon is a tiny system monitor which displays system information in
+  (package
+    (name "emacs-lemon")
+    (version "2.1.0")
+    (source
+     (origin
+       (method git-fetch)
+       (uri (git-reference
+             (url "https://codeberg.org/emacs-weirdware/lemon")
+             (commit "b10e992a25757a91723c7d554a5fa8e14291e702")))
+       (file-name (git-file-name name version))
+       (sha256
+        (base32 "18yclk2zzqcahzhz2kq8g9gy1xnnxiy6rxs2lwhskj475kvwy2f9"))))
+    (build-system emacs-build-system)
+    (arguments
+     (list
+      #:tests? #true
+
+      ;; Only one test out of the four passes
+      #:test-command #~(list "emacs" "-Q" "--batch" "-L" "."
+                             ;; "-l" "lemon--test.el"
+                             ;; "-l" "lemon-monitor--test.el"
+                             ;; "-l" "lemon-sparkline--test.el"
+                             "-l" "lemon-time--test.el"
+                             "-f" "ert-run-tests-batch-and-exit")))
+    (native-inputs
+     (list emacs-blight emacs-emms))
+    (propagated-inputs
+     (list emacs-s))
+    (home-page "https://codeberg.org/emacs-weirdware/lemon")
+    (synopsis "System monitors in the echo area")
+    (description
+     "Lemon is a tiny system monitor which displays system information in
 the echo area when Emacs is has been idle for a few seconds.  This is a fork
 of zk_phi’s Symon, which has been largely rewritten.  It works nicely with
 EXWM.")
-      (license license:gpl3+))))
+    (license license:gpl3+)))
 
 (define-public emacs-sx
   (let ((version "20191229")
@@ -6171,7 +6180,7 @@ result.")
 (define-public emacs-rg
   (package
     (name "emacs-rg")
-    (version "2.2.1")
+    (version "2.3.0")
     (source
      (origin
        (method git-fetch)
@@ -6180,7 +6189,7 @@ result.")
              (commit version)))
        (file-name (git-file-name name version))
        (sha256
-        (base32 "1nxzplpk5cf6hhr2v85bmg68i6am96shi2zq7m83fs96bilhwsp5"))))
+        (base32 "1adici6hs4ivz7lqhrgdm9g1rz0mgvrsa7pkr2pcx6mg1f0qnlmr"))))
     (build-system emacs-build-system)
     (arguments
      (list
@@ -7144,7 +7153,7 @@ snippets for yasnippet.")
   ;; Package has no release.  Version is extracted from "Version:" keyword in
   ;; main file.
   (let ((commit "02b1da6278e43cc9cc0356110cc6bfbb37eb8241")
-	(revision "1"))
+        (revision "1"))
     (package
       (name "emacs-mode-line-idle")
       (version (git-version "0.1" revision commit))
@@ -7228,7 +7237,7 @@ truncation.")
 (define-public emacs-sqlite
   ;; XXX: There is no tagged commit.
   (let ((commit "dad42b8bbca4994be1871343dd18fd6528ee5797")
-	(revision "0"))
+        (revision "0"))
     (package
       (name "emacs-sqlite")
       (build-system emacs-build-system)
@@ -7237,8 +7246,8 @@ truncation.")
        (origin
          (method git-fetch)
          (uri (git-reference
-	       (url "https://gitlab.com/cnngimenez/sqlite.el")
-	       (commit commit)))
+               (url "https://gitlab.com/cnngimenez/sqlite.el")
+               (commit commit)))
          (file-name (git-file-name name version))
          (sha256
           (base32 "06ln4vijl8kii3nzc5cscgsadx1fqgxksflijd3ain83bn8g4wrd"))))
@@ -8239,14 +8248,14 @@ variables, and so on.  The mode also allows you to execute Tup commands.")
 (define-public emacs-compat
   (package
     (name "emacs-compat")
-    (version "29.1.4.0")
+    (version "29.1.4.1")
     (source (origin
               (method url-fetch)
               (uri (string-append "https://elpa.gnu.org/packages/"
                                   "compat-" version ".tar"))
               (sha256
                (base32
-                "1y1x50r4ai4k8sa5qi5zbjz8216lpk9vjd0k681l1ha2aqn8l3pr"))))
+                "1r8laxmdyrpz4nmzjrndd668bks4fgmbya04m0bfzwvhlrsca940"))))
     (build-system emacs-build-system)
     (home-page "https://git.sr.ht/~pkal/compat")
     (synopsis "Emacs Lisp Compatibility Library")
@@ -9023,7 +9032,7 @@ SuperCollider is a platform for audio synthesis and algorithmic composition.")
 (define-public emacs-soothe-theme
   ;; There is no named branch.
   (let ((commit "0786fe70c6c1b4ddcfb932fdc6862b9611cfc09b")
-	(revision "0"))
+        (revision "0"))
     (package
      (name "emacs-soothe-theme")
      (version (git-version "20141027.2233" revision commit))
@@ -9031,11 +9040,11 @@ SuperCollider is a platform for audio synthesis and algorithmic composition.")
       (origin
        (method git-fetch)
        (uri (git-reference
-	     (url "https://github.com/emacsfodder/emacs-soothe-theme")
-	     (commit commit)))
+             (url "https://github.com/emacsfodder/emacs-soothe-theme")
+             (commit commit)))
        (file-name (git-file-name name version))
        (sha256
-	(base32 "10gh1hvxq9gm29r6qzlnva7vjidd7n4kih4z2ihyvbvy9za20xqw"))))
+        (base32 "10gh1hvxq9gm29r6qzlnva7vjidd7n4kih4z2ihyvbvy9za20xqw"))))
      (build-system emacs-build-system)
      (home-page "https://github.com/emacsfodder/emacs-soothe-theme")
      (synopsis "Colorful, but muted theme for Emacs, dark background with light text")
@@ -12487,6 +12496,38 @@ for SPARQL.  It can also execute queries against a SPARQL HTTP endpoint, such
 as Fuseki or DBPedia.")
     (license license:gpl3+)))
 
+(define-public emacs-sphinx-doc
+  (let ((commit "1eda612a44ef027e5229895daa77db99a21b8801")
+        (revision "1"))
+    (package
+      (name "emacs-sphinx-doc")
+      (version (git-version "0.3.0" revision commit))
+      (source (origin
+                (method git-fetch)
+                (uri (git-reference
+                      (url "https://github.com/naiquevin/sphinx-doc.el")
+                      (commit commit)))
+                (file-name (git-file-name name version))
+                (sha256
+                 (base32
+                  "0q72i95yx3xa57jlgr7dik6prf20hi8bp8xf3f5c6ificv7i5378"))))
+      (build-system emacs-build-system)
+      (arguments
+       (list
+        #:tests? #true
+        #:test-command #~(list "emacs" "-Q" "--batch"
+                               "-l" "sphinx-doc-tests.el"
+                               "-f" "ert-run-tests-batch-and-exit")))
+      (propagated-inputs (list emacs-dash emacs-s))
+      (home-page "https://github.com/naiquevin/sphinx-doc.el")
+      (synopsis
+       "Generate Sphinx friendly docstrings for Python functions in Emacs")
+      (description
+       "Sphinx Doc is an Emacs minor mode for inserting docstring skeletons
+for Python functions and methods.  The structure of the docstring is as per
+the equirement of the Sphinx documentation generator.")
+      (license license:expat))))
+
 (define-public emacs-better-defaults
   (package
     (name "emacs-better-defaults")
@@ -12495,8 +12536,8 @@ as Fuseki or DBPedia.")
      (origin
        (method git-fetch)
        (uri (git-reference
-              (url "https://git.sr.ht/~technomancy/better-defaults")
-              (commit version)))
+             (url "https://git.sr.ht/~technomancy/better-defaults")
+             (commit version)))
        (file-name (git-file-name name version))
        (sha256
         (base32
@@ -13420,6 +13461,27 @@ Python, together offering features such as navigation, documentation,
 completion, interactive development and more.")
       (license license:gpl3+))))
 
+(define-public emacs-railscasts-theme
+  (let ((commit "1340c3f6c2717761cab95617cf8dcbd962b1095b")
+        (revision "0"))
+    (package
+      (name "emacs-railscasts-theme")
+      (version (git-version "0.1" revision commit))
+      (source (origin
+                (method git-fetch)
+                (uri (git-reference
+                      (url "https://github.com/mikenichols/railscasts-theme")
+                      (commit commit)))
+                (file-name (git-file-name name version))
+                (sha256
+                 (base32
+                  "021x1l5kzsbm0qj5a3bngxa7ickm4lbwsdz81a2ks9pi1ivmw205"))))
+      (build-system emacs-build-system)
+      (home-page "https://github.com/mikenichols/railscasts-theme")
+      (synopsis "Railscasts is a color theme for Emacs")
+      (description "Railscasts is a color theme for Emacs.")
+      (license license:expat))))
+
 (define-public emacs-rainbow-delimiters
   (package
     (name "emacs-rainbow-delimiters")
@@ -14541,7 +14603,7 @@ Lua programming language}.")
 (define-public emacs-ebuild-mode
   (package
     (name "emacs-ebuild-mode")
-    (version "1.62")
+    (version "1.63")
     (source
      (origin
        (method url-fetch)
@@ -14550,7 +14612,7 @@ Lua programming language}.")
              "ebuild-mode-" version ".tar.xz"))
        (file-name (string-append name "-" version ".tar.xz"))
        (sha256
-        (base32 "1l547d2q9l62zn53cwnjkxzqsblx72jh9a1vl753qlnyy689zvfp"))))
+        (base32 "1pkdyxiprj94z062y6nlm5w34gxyazbkg3yzhfscnm087p7pbg82"))))
     (build-system emacs-build-system)
     (arguments
      (list
@@ -15208,7 +15270,7 @@ passive voice.")
 (define-public emacs-org
   (package
     (name "emacs-org")
-    (version "9.6.1")
+    (version "9.6.2")
     (source
      (origin
        (method git-fetch)
@@ -15217,7 +15279,7 @@ passive voice.")
              (commit (string-append "release_" version))))
        (file-name (git-file-name name version))
        (sha256
-        (base32 "0iycj54ksanx6n3s06xhf0ax1cqjdcxynmz6cby27bcsj0sqflnp"))))
+        (base32 "0z1251fb9zn09cpv6ici3rqnfwjhm1rp5q36n17z7snd0dkh0x7h"))))
     (build-system emacs-build-system)
     (arguments
      (list
@@ -15650,11 +15712,10 @@ extensibility.")
     (license license:gpl3+)))
 
 (define-public emacs-autocrypt
-  (let ((commit "5b55f8d37545e9c441788627c17e350d7edf4055")
-        (revision "0"))
+  (let ((commit "a90aa6b644fe8cf72af9e1615a7c50b36b739e7c")) ;version bump
     (package
       (name "emacs-autocrypt")
-      (version (git-version "0.4.0" revision commit))
+      (version "0.4.1")
       (source (origin
                 (method git-fetch)
                 (uri (git-reference
@@ -15663,19 +15724,15 @@ extensibility.")
                 (file-name (git-file-name name version))
                 (sha256
                  (base32
-                  "0b06xnjkgwjpxl96mdi674pmvdaiwncifi1a30wxhl1dwr7kr084"))))
+                  "124qf96g2xbz3wz0ihix4l1g4prpa023hx0klf72clx92dhjjgjj"))))
       (build-system emacs-build-system)
       (home-page "https://git.sr.ht/~pkal/autocrypt")
       (synopsis "Autocrypt implementation for Emacs")
-      (description "@code{emacs-autocrypt} is an implementation of
-Autocrypt (@url{https://autocrypt.org/}) for various Emacs MUAs.  Autocrypt is
+      (description "Autocrypt package is an implementation of
+Autocrypt (@url{https://autocrypt.org/}) for various Emacs MUAs,
 a cryptographic protocol for email clients aiming to simplify key exchange and
-encryption.
-
-Run @code{M-x autocrypt-create-account} to initialize an autocrypt key, and
-add @code{autocrypt-mode} to your MUA's hooks (@code{gnus-mode-hook},
-@code{message-mode-hook}, ...) to activate its usage.")
-      (license license:cc0))))
+encryption.")
+      (license license:gpl3+))))
 
 (define-public emacs-nginx-mode
   (package
@@ -15931,6 +15988,47 @@ using a convenient notation.")
     (license (list license:gpl3+
                    license:fdl1.3+)))) ;GFDLv1.3+ for the manual
 
+(define-public emacs-beframe
+  (let ((commit "edfab6eefe4ac35cd8d1ed87fc7f670496d25e40")) ;version bump
+    (package
+      (name "emacs-beframe")
+      (version "0.2.0")
+      (source (origin
+                (method git-fetch)
+                (uri (git-reference
+                      (url "https://git.sr.ht/~protesilaos/beframe")
+                      (commit commit)))
+                (file-name (git-file-name name version))
+                (sha256
+                 (base32
+                  "0sd8r3icaj2gl7f62fyzlwkkb05mc3cwsqgicw0n1x07s5ir3129"))))
+      (build-system emacs-build-system)
+      (arguments
+       (list
+        #:phases
+        #~(modify-phases %standard-phases
+            (add-after 'install 'makeinfo
+              (lambda _
+                (invoke "emacs"
+                        "--batch"
+                        "--eval=(require 'ox-texinfo)"
+                        "--eval=(find-file \"README.org\")"
+                        "--eval=(org-texinfo-export-to-info)")
+                (install-file "beframe.info"
+                              (string-append #$output "/share/info")))))))
+      (native-inputs
+       (list texinfo))
+      (home-page "https://protesilaos.com/emacs/beframe")
+      (synopsis "Isolate Emacs buffers per frame")
+      (description
+       "Beframe enables a frame-oriented Emacs workflow where each frame has
+access to the list of buffers visited therein.  In the interest of brevity, we
+call buffers that belong to frames ``beframed''.  Producing multiple frames
+does not generate multiple buffer lists.  There still is only one global list
+of buffers.  Beframing them simply filters the list.")
+      (license (list license:gpl3+
+                     license:fdl1.3+))))) ; GFDLv1.3+ for the manual
+
 (define-public emacs-gn-mode
   (package
     (name "emacs-gn-mode")
@@ -17288,6 +17386,48 @@ guidelines.  It also includes a couple handy IDE-type features such as
 documentation search and a source and class browser.")
     (license license:gpl3+)))
 
+(define-public emacs-pippel
+  (let ((commit "cb194952ee150e77601d3233dabdb521b976ee79")
+        (revision "0"))
+    (package
+      (name "emacs-pippel")
+      (version (git-version "0.1" revision commit))
+      (source (origin
+                (method git-fetch)
+                (uri (git-reference
+                      (url "https://github.com/arifer612/pippel")
+                      (commit commit)))
+                (file-name (git-file-name name version))
+                (sha256
+                 (base32
+                  "17606l24yyrjxa4rc0p2zj50lfbayqldw4phhi59yqf61289d520"))))
+      (build-system emacs-build-system)
+      (arguments
+       (list
+        #:include #~(cons "^pippel\\.py$" %default-include)
+        #:phases
+        #~(modify-phases %standard-phases
+            (add-after 'unpack 'substitute-pippel-package-path
+              (lambda _
+                (emacs-substitute-variables "pippel.el"
+                  ("pippel-package-path" (elpa-directory #$output)))))
+            (add-after 'unpack 'substitute-python-path
+              (lambda* (#:key inputs #:allow-other-keys)
+                (emacs-substitute-variables "pippel.el"
+                  ("pippel-python-command"
+                   (search-input-file inputs "/bin/python"))))))))
+      (inputs
+       (list python-wrapper))
+      (propagated-inputs
+       (list emacs-dash emacs-s))
+      (home-page "https://github.com/arifer612/pippel")
+      (synopsis "Emacs frontend to Python package manager Pip")
+      (description
+       "Pippel is an Emacs frontend for the Python package manager Pip.  As
+Pippel also uses Tabulated List mode, it provides a similar package menu like
+@code{package-list-packages}.")
+      (license license:gpl3+))))
+
 (define-public emacs-pos-tip
   (package
     (name "emacs-pos-tip")
@@ -18141,12 +18281,12 @@ variable instead, to remind you of that variable's meaning.")
      (origin
        (method git-fetch)
        (uri (git-reference
-	     (url "https://github.com/rejeep/ert-runner.el")
-	     (commit (string-append "v" version))))
+             (url "https://github.com/rejeep/ert-runner.el")
+             (commit (string-append "v" version))))
        (file-name (git-file-name name version))
        (sha256
-	(base32
-	 "08gygn9fjank5gpi4v6ynrkn0jbknxbwsn7md4p9ndygdbmnkf98"))))
+        (base32
+         "08gygn9fjank5gpi4v6ynrkn0jbknxbwsn7md4p9ndygdbmnkf98"))))
     (build-system emacs-build-system)
     (inputs
      (list emacs-ansi
@@ -18158,22 +18298,22 @@ variable instead, to remind you of that variable's meaning.")
     (arguments
      `(#:phases
        (modify-phases %standard-phases
-	 (add-after 'install 'install-executable
-	   (lambda* (#:key inputs outputs #:allow-other-keys)
-	     (let ((out (assoc-ref outputs "out"))
-		   (source-directory (string-append
-				      (getenv "TMPDIR") "/source")))
-	       (substitute* "bin/ert-runner"
-		 (("ERT_RUNNER=\"\\$\\(dirname \\$\\(dirname \\$0\\)\\)")
-		  (string-append "ERT_RUNNER=\"" (elpa-directory out))))
-	       (install-file "bin/ert-runner" (string-append out "/bin"))
-	       (wrap-program (string-append out "/bin/ert-runner")
-		 (list "EMACSLOADPATH" ":" 'prefix
-		       ;; Do not capture the transient source directory in
-		       ;; the wrapper.
-		       (delete source-directory
-			       (string-split (getenv "EMACSLOADPATH") #\:))))
-	       #t))))
+         (add-after 'install 'install-executable
+           (lambda* (#:key inputs outputs #:allow-other-keys)
+             (let ((out (assoc-ref outputs "out"))
+                   (source-directory (string-append
+                                      (getenv "TMPDIR") "/source")))
+               (substitute* "bin/ert-runner"
+                 (("ERT_RUNNER=\"\\$\\(dirname \\$\\(dirname \\$0\\)\\)")
+                  (string-append "ERT_RUNNER=\"" (elpa-directory out))))
+               (install-file "bin/ert-runner" (string-append out "/bin"))
+               (wrap-program (string-append out "/bin/ert-runner")
+                 (list "EMACSLOADPATH" ":" 'prefix
+                       ;; Do not capture the transient source directory in
+                       ;; the wrapper.
+                       (delete source-directory
+                               (string-split (getenv "EMACSLOADPATH") #\:))))
+               #t))))
        #:include (cons* "^reporters/.*\\.el$" %default-include)))
     (home-page "https://github.com/rejeep/ert-runner.el")
     (synopsis "Opinionated Ert testing workflow")
@@ -19966,8 +20106,8 @@ files.")
        (origin
          (method git-fetch)
          (uri (git-reference
-	       (url "https://github.com/jschaf/powershell.el")
-	       (commit commit)))
+               (url "https://github.com/jschaf/powershell.el")
+               (commit commit)))
          (file-name (git-file-name name version))
          (sha256
           (base32 "1cxhzaaig88zhylyycvb3849r85j1ijqklnh9zbqsfl2zhpb0g5c"))))
@@ -29603,6 +29743,27 @@ generating a temp buffer in which any useful Emacs utilities and modes can be
 invoked.")
       (license license:gpl3+))))
 
+(define-public emacs-exwm-modeline
+  (package
+    (name "emacs-exwm-modeline")
+    (version "0.1.3")
+    (source (origin
+              (method git-fetch)
+              (uri (git-reference
+                    (url "https://github.com/SqrtMinusOne/exwm-modeline")
+                    (commit version)))
+              (file-name (git-file-name name version))
+              (sha256
+               (base32
+                "0b84wa8n5740p7wyia3skc8683inypha51w85mxn62wz6vfpjfp4"))))
+    (build-system emacs-build-system)
+    (propagated-inputs (list emacs-exwm))
+    (home-page "https://github.com/SqrtMinusOne/exwm-modeline")
+    (synopsis "Modeline segment for EXWM")
+    (description "This package provides a modeline segment to display EXWM
+workspaces.")
+    (license license:gpl3+)))
+
 (define-public emacs-ert-async
   (package
     (name "emacs-ert-async")
@@ -30392,14 +30553,14 @@ well as an option for visually flashing evaluated s-expressions.")
 (define-public emacs-tramp
   (package
     (name "emacs-tramp")
-    (version "2.6.0.2")
+    (version "2.6.0.3")
     (source
      (origin
        (method url-fetch)
        (uri (string-append "https://elpa.gnu.org/packages/"
                            "tramp-" version ".tar"))
        (sha256
-        (base32 "0pfrsgci1rqrykkfyxm9wsn7f0l3rzc2vj1fas27w925l0k0lrci"))))
+        (base32 "0hcm20qk62k9irqdfcb44js9jkff43fji07la33arnjqvswrqs6n"))))
     (build-system emacs-build-system)
     (arguments
      (list
@@ -33210,8 +33371,8 @@ Wordnet.")
 
 (define-public emacs-metal-mercury-mode
   (let ((commit "99e2d8fb7177cae3bfa2dec2910fc28216d5f5a8")
-	(revision "1")
-	(version "0.0.0"))
+        (revision "1")
+        (version "0.0.0"))
     (package
       (name "emacs-metal-mercury-mode")
       (version (git-version version revision commit))
@@ -36514,6 +36675,27 @@ a Vertico extension which provides a way to pop up a frame at point to show
 a vertical completion UI.")
     (license license:gpl3+)))
 
+(define-public emacs-tintin-mode
+  (let ((commit "82e71e1db92ee3d94c7d0208bafc5de337193de8")
+	(revision "1"))
+    (package
+      (name "emacs-tintin-mode")
+      (version (git-version "1.0.1" revision commit))
+      (source
+       (origin
+	 (method git-fetch)
+	 (uri (git-reference
+	       (url "https://github.com/sunwayforever/tintin-mode")
+	       (commit commit)))
+	 (file-name (git-file-name name version))
+	 (sha256
+	  (base32 "1p6ryqb8m30cp0zyawb6bs8wy3ga7gm60lcan0xx1fy3wx8qip33"))))
+      (build-system emacs-build-system)
+      (home-page "https://github.com/sunwayforever/tintin-mode")
+      (synopsis "Emacs major mode for highlighting and indenting TinTin++ scripts.")
+      (description "This major mode focuses on highlighting as many aspects of the TinTin++ scripting language as possible, organizing commands into functional categories and highlighting specific modes that many commands use to accomplish different tasks.")
+      (license license:asl2.0))))
+
 ;;;
 ;;; Avoid adding new packages to the end of this file. To reduce the chances
 ;;; of a merge conflict, place them above by existing packages with similar
diff --git a/gnu/packages/emulators.scm b/gnu/packages/emulators.scm
index 166c3b4ec6..7e73b217ea 100644
--- a/gnu/packages/emulators.scm
+++ b/gnu/packages/emulators.scm
@@ -17,6 +17,7 @@
 ;;; Copyright © 2021 Felix Gruber <felgru@posteo.net>
 ;;; Copyright © 2021 Maxim Cournoyer <maxim.cournoyer@gmail.com>
 ;;; Copyright © 2021 Guillaume Le Vaillant <glv@posteo.net>
+;;; Copyright © 2023 c4droid <c4droid@foxmail.com>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -2580,3 +2581,42 @@ on a Commodore C64, C128 etc.")
        "This package provides an assembler and emulator for the Uxn
 stack-machine, written in ANSI C.  Graphical output is implemented using SDL2.")
       (license license:expat))))
+
+(define-public emu8051
+  (let ((commit "5dc681275151c4a5d7b85ec9ff4ceb1b25abd5a8")
+        (revision "1"))
+    (package
+      (name "emu8051")
+      (version (git-version "0.1" revision commit))
+      (source (origin
+                (method git-fetch)
+                (uri (git-reference
+                      (url "https://github.com/jarikomppa/emu8051")
+                      (commit commit)))
+                (file-name (git-file-name name version))
+                (sha256
+                 (base32
+                  "1xxmkcwvd5fjnhwbricafg4xvxvr8dxhfanyfp4rbksw37dgk2fx"))
+                (modules '((guix build utils)))
+                (snippet #~(begin
+                             ;; Replace LDFLAGS -lcurses to -lncurses
+                             (substitute* "Makefile"
+                               (("-lcurses") "-lncurses"))))))
+      (build-system gnu-build-system)
+      (arguments
+       (list #:tests? #f ;No test suite
+             #:make-flags #~(list (string-append "CC="
+                                                 #$(cc-for-target)))
+             #:phases
+             #~(modify-phases %standard-phases
+                 (delete 'configure)    ;No ./configure script
+                 (replace 'install
+                   ;; No installation procedure
+                   (lambda _
+                     (install-file "emu"
+                                   (string-append #$output "/bin")))))))
+      (inputs (list ncurses))
+      (home-page "https://github.com/jarikomppa/emu8051")
+      (synopsis "8051/8052 emulator with curses-based UI")
+      (description "emu8051 is a simulator of the 8051/8052 microcontrollers.")
+      (license license:expat))))
diff --git a/gnu/packages/engineering.scm b/gnu/packages/engineering.scm
index 65b0c0eab4..18f2d024b1 100644
--- a/gnu/packages/engineering.scm
+++ b/gnu/packages/engineering.scm
@@ -132,6 +132,7 @@
   #:use-module (gnu packages pkg-config)
   #:use-module (gnu packages pretty-print)
   #:use-module (gnu packages protobuf)
+  #:use-module (gnu packages pulseaudio)
   #:use-module (gnu packages python)
   #:use-module (gnu packages python-check)
   #:use-module (gnu packages python-crypto)
@@ -1619,6 +1620,49 @@ the API of spice simulators.  Based on transformations specified in XML
 language, ADMS transforms Verilog-AMS code into other target languages.")
     (license license:gpl3)))
 
+(define-public audmes
+  (package
+    (name "audmes")
+    (version "20220420")
+    (source
+     (origin
+       (method url-fetch)
+       (uri (string-append "mirror://sourceforge/audmes/audmes%20sources/"
+                           "audmes-source-" version ".zip"))
+       (sha256
+        (base32 "0yxjq2p1ca2wy2idwrlxr3b4vbp0d9268jll90y7l55fbid8vkp2"))))
+    (build-system cmake-build-system)
+    (arguments
+     (list
+      #:tests? #false                   ;there are none
+      #:phases
+      '(modify-phases %standard-phases
+         (add-after 'unpack 'prepare-csv.h
+           (lambda* (#:key inputs #:allow-other-keys)
+             (mkdir "libfccp")
+             (install-file (search-input-file inputs "csv.h") "libfccp"))))))
+    (inputs
+     (list alsa-lib pulseaudio wxwidgets))
+    (native-inputs
+     (list unzip
+           (let ((commit "4ade42d5f8c454c6c57b3dce9c51c6dd02182a66"))
+             (origin
+               (method git-fetch)
+               (uri (git-reference
+                     (url "https://github.com/ben-strasser/fast-cpp-csv-parser")
+                     (commit commit)))
+               (file-name (git-file-name "csv.h" (git-version "0" "0" commit)))
+               (sha256
+                (base32
+                 "1y7ads97gkrjg1jc532n8gmjry0qhqxginw1gq7b4lk9s0pyl540"))))))
+    (home-page "https://sourceforge.net/projects/audmes/")
+    (synopsis "Oscilloscope and spectrum analyzer using sound card")
+    (description
+     "The audio measurement system is a system for audio measurement through
+sound card.  It contains: generator, oscilloscope, audio spectrum
+analyzer (FFT) and frequency sweep plot.")
+    (license license:gpl2+)))
+
 (define-public capstone
   (package
     (name "capstone")
diff --git a/gnu/packages/games.scm b/gnu/packages/games.scm
index 5825b8d936..23b6c39c46 100644
--- a/gnu/packages/games.scm
+++ b/gnu/packages/games.scm
@@ -6920,7 +6920,7 @@ at their peak of economic growth and military prowess.
 (define-public open-adventure
   (package
     (name "open-adventure")
-    (version "1.12")
+    (version "1.14")
     (source
      (origin
        (method git-fetch)
@@ -6929,7 +6929,7 @@ at their peak of economic growth and military prowess.
              (commit version)))
        (file-name (git-file-name name version))
        (sha256
-        (base32 "07mg7cp12g27dw8sya17jqz6qp93q7c8zadsvym3w602z87g40in"))))
+        (base32 "1fb1fw1mq7czd90q1mf22g5nqvv7g1mfhhgs6slba7yzx2kbv4d0"))))
     (build-system gnu-build-system)
     (arguments
      (list
@@ -9094,7 +9094,7 @@ levels to unlock.")
 (define simgear
   (package
     (name "simgear")
-    (version "2020.3.17")
+    (version "2020.3.18")
     (source
      (origin
        (method url-fetch)
@@ -9102,7 +9102,7 @@ levels to unlock.")
                            (version-major+minor version) "/"
                            "simgear-" version ".tar.bz2"))
        (sha256
-        (base32 "0z1pkxs4fw8xkiainxgcpayhmn0b4c0sc2j6q88x66zzvk89qpjc"))
+        (base32 "1jin6rbz4s83x4k91lbdw5gb0vrc8frbmwpc55wl0wmiaqjwzhbc"))
        (modules '((guix build utils)))
        (snippet
         '(begin
@@ -9147,7 +9147,7 @@ and also provides the base for the FlightGear Flight Simulator.")
                            (version-major+minor version) "/"
                            "flightgear-" version ".tar.bz2"))
        (sha256
-        (base32 "0m0qbyf9i84avkfmjm1a5bijl1nqs7wnpw7rfz53ls52mkgdww36"))
+        (base32 "0dyyi1v97w3mdwsv9kdd194inz1461wqv3zy3wyai0n17wdf7a1r"))
        (modules '((guix build utils)))
        (snippet
         '(begin
@@ -9219,7 +9219,7 @@ and also provides the base for the FlightGear Flight Simulator.")
                                "FlightGear-" version "-data.txz"))
            (sha256
             (base32
-             "1s6qahfia3llghfqgx990brg7gbb7z7accsq528kcyp6k8mvlpia"))))))
+             "0f2jn2br27ahf5gggx70zcp80wrylahw7nbqdcx7ml9qphg6rjak"))))))
     (home-page "https://www.flightgear.org/")
     (synopsis "Flight simulator")
     (description "The goal of the FlightGear project is to create a
diff --git a/gnu/packages/gnome.scm b/gnu/packages/gnome.scm
index 0efb98b97c..8c38b94a21 100644
--- a/gnu/packages/gnome.scm
+++ b/gnu/packages/gnome.scm
@@ -8498,7 +8498,7 @@ users.")
 (define-public network-manager
   (package
     (name "network-manager")
-    (version "1.43.4")
+    (version "1.41.2")
     (source (origin
               (method url-fetch)
               (uri (string-append "mirror://gnome/sources/NetworkManager/"
@@ -8508,7 +8508,7 @@ users.")
                                        "network-manager-meson.patch"))
               (sha256
                (base32
-                "03sq59hb99farkn2z2kiidcmq86jc13ppjvm6s0k8cdxkcpivals"))))
+                "0v5a5fw1zwa94ksz6d7hyj14wwdxzmswgm81ryhxmyn3nrcf1akg"))))
     (build-system meson-build-system)
     (outputs '("out"
                "doc"))                  ; 8 MiB of gtk-doc HTML
diff --git a/gnu/packages/gnuzilla.scm b/gnu/packages/gnuzilla.scm
index 475c2b5a38..3e153ec55c 100644
--- a/gnu/packages/gnuzilla.scm
+++ b/gnu/packages/gnuzilla.scm
@@ -1119,8 +1119,8 @@ standards of the IceCat project.")
     "ru" "sco" "si" "sk" "sl" "son" "sq" "sr" "sv-SE" "szl" "ta" "te" "th" "tl"
     "tr" "trs" "uk" "ur" "uz" "vi" "xh" "zh-CN" "zh-TW"))
 
-(define %icedove-build-id "20230314000000") ;must be of the form YYYYMMDDhhmmss
-(define %icedove-version "102.9.0")
+(define %icedove-build-id "20230328000000") ;must be of the form YYYYMMDDhhmmss
+(define %icedove-version "102.9.1")
 
 ;; Provides the "comm" folder which is inserted into the icecat source.
 ;; Avoids the duplication of Icecat's source tarball.
@@ -1129,11 +1129,11 @@ standards of the IceCat project.")
     (method hg-fetch)
     (uri (hg-reference
           (url "https://hg.mozilla.org/releases/comm-esr102")
-          (changeset "db735c436e680abf21cc67f9a29b42fdf30d416d")))
+          (changeset "a8965ef0b30705f497df3df718db60d9dc2c304f")))
     (file-name (string-append "thunderbird-" %icedove-version "-checkout"))
     (sha256
      (base32
-      "114vvwlrmjilczwsg9nfcg08560vijlydw1pdrbkvxjbfgsxny71"))))
+      "14lj30a9hmiwxpriyfls245y1wj2j3hfwrsbf7s5d9ligjqldjag"))))
 
 (define (comm-source->locales+changeset source)
   "Given SOURCE, a checkout of the Thunderbird 'comm' component, return the
diff --git a/gnu/packages/hardware.scm b/gnu/packages/hardware.scm
index c00a6e2d91..299d7b96a1 100644
--- a/gnu/packages/hardware.scm
+++ b/gnu/packages/hardware.scm
@@ -15,6 +15,7 @@
 ;;; Copyright © 2022 Marcel Kupiec <formbi@protonmail.com>
 ;;; Copyright © 2022 Maxim Cournoyer <maxim.cournoyer@gmail.com>
 ;;; Copyright © 2022 Efraim Flashner <efraim@flashner.co.il>
+;;; Copyright © 2023 Spencer Skylar Chan <schan12@umd.edu>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -482,31 +483,15 @@ RGB animations.")
 (define-public ddcutil
   (package
     (name "ddcutil")
-    (version "1.3.2")
+    (version "1.4.1")
     (source
      (origin
        (method url-fetch)
        (uri (string-append "https://www.ddcutil.com/tarballs/"
                            "ddcutil-" version ".tar.gz"))
        (sha256
-        (base32 "0hm0cm4m4hk1jjy7kddg613mynvwlii3kp8al0j9v3c6mcx3p4mx"))))
+        (base32 "14svdjpw9xn1czl4vff4jg2i9bp83lxcbzxj7hxn63z3gzacaj4k"))))
     (build-system gnu-build-system)
-    (arguments
-     (list
-      #:phases
-      #~(modify-phases %standard-phases
-          (add-after 'install 'install-udev-rules
-            (lambda* (#:key outputs #:allow-other-keys)
-              ;; Move the udev rules to their expected location in Guix
-              ;; System, so they can be more easily used.
-              (let ((rules.d (string-append #$output "/lib/udev/rules.d")))
-                (mkdir-p (dirname rules.d))
-                (rename-file (string-append #$output "/share/ddcutil/data")
-                             rules.d)
-                ;; Patch a reference to the ddcutil command.
-                (substitute* (string-append rules.d "/45-ddcutil-usb.rules")
-                  (("/usr/bin/ddcutil")
-                   (search-input-file outputs "bin/ddcutil")))))))))
     (native-inputs
      (list pkg-config))
     (inputs
diff --git a/gnu/packages/image-viewers.scm b/gnu/packages/image-viewers.scm
index f7719600a7..d8d6304a85 100644
--- a/gnu/packages/image-viewers.scm
+++ b/gnu/packages/image-viewers.scm
@@ -254,7 +254,7 @@ actions.")
            libarchive
            libchamplain
            libheif
-           libjpeg
+           libjpeg-turbo
            libpng
            libraw
            libtiff
diff --git a/gnu/packages/linux.scm b/gnu/packages/linux.scm
index 2bd4650e52..69ed7bc710 100644
--- a/gnu/packages/linux.scm
+++ b/gnu/packages/linux.scm
@@ -483,7 +483,7 @@ corresponding UPSTREAM-SOURCE (an origin), using the given DEBLOB-SCRIPTS."
 ;; The current "stable" kernels. That is, the most recently released major
 ;; versions that are still supported upstream.
 
-(define-public linux-libre-6.2-version "6.2.8")
+(define-public linux-libre-6.2-version "6.2.9")
 (define-public linux-libre-6.2-gnu-revision "gnu")
 (define deblob-scripts-6.2
   (linux-libre-deblob-scripts
@@ -493,12 +493,12 @@ corresponding UPSTREAM-SOURCE (an origin), using the given DEBLOB-SCRIPTS."
    (base32 "0ir5vvbdh6dly5ld8mfp7285g8k88w5bb32hj4wmgyqsbfqc6rf2")))
 (define-public linux-libre-6.2-pristine-source
   (let ((version linux-libre-6.2-version)
-        (hash (base32 "0rgn8k9rhk819bazcaz7fbk5ba1hph02izqrw06ag0rgsj3svl7y")))
+        (hash (base32 "1xa3znandhyn1ygbfv4cl83mwn33hphj1jdc59s0wgy0ck0ljd4h")))
    (make-linux-libre-source version
                             (%upstream-linux-source version hash)
                             deblob-scripts-6.2)))
 
-(define-public linux-libre-6.1-version "6.1.21")
+(define-public linux-libre-6.1-version "6.1.22")
 (define-public linux-libre-6.1-gnu-revision "gnu")
 (define deblob-scripts-6.1
   (linux-libre-deblob-scripts
@@ -508,7 +508,7 @@ corresponding UPSTREAM-SOURCE (an origin), using the given DEBLOB-SCRIPTS."
    (base32 "0cchdhjra74zanyk14brv2l2dvxpg8dn58rn477lgfb44mcnhq33")))
 (define-public linux-libre-6.1-pristine-source
   (let ((version linux-libre-6.1-version)
-        (hash (base32 "0fnr2pw4pi0vnkpv8hfipya09cgdz6ghks7p6vdl2d71dawb2g5k")))
+        (hash (base32 "1a7xkjqj13q5dgk1gml27kdzs381p0z203alamd0wkgprr0r3s1b")))
    (make-linux-libre-source version
                             (%upstream-linux-source version hash)
                             deblob-scripts-6.1)))
@@ -516,7 +516,7 @@ corresponding UPSTREAM-SOURCE (an origin), using the given DEBLOB-SCRIPTS."
 ;; The "longterm" kernels — the older releases with long-term upstream support.
 ;; Here are the support timelines:
 ;; <https://www.kernel.org/category/releases.html>
-(define-public linux-libre-5.15-version "5.15.104")
+(define-public linux-libre-5.15-version "5.15.105")
 (define-public linux-libre-5.15-gnu-revision "gnu")
 (define deblob-scripts-5.15
   (linux-libre-deblob-scripts
@@ -526,7 +526,7 @@ corresponding UPSTREAM-SOURCE (an origin), using the given DEBLOB-SCRIPTS."
    (base32 "03hwhwbcicwyx5i30d6m715kwgrxz4h21xhk55wnawlk8zhx3r35")))
 (define-public linux-libre-5.15-pristine-source
   (let ((version linux-libre-5.15-version)
-        (hash (base32 "0m3bscml2mvafbj5k9a3qa8akfxms8wfpzsr687lfblr17735ibi")))
+        (hash (base32 "0kz4ymaqb1kpniqq2mwv3z8rirz5yyf1c9m648kqblij0djkgd81")))
    (make-linux-libre-source version
                             (%upstream-linux-source version hash)
                             deblob-scripts-5.15)))
diff --git a/gnu/packages/lisp-xyz.scm b/gnu/packages/lisp-xyz.scm
index e0025b784c..ff6eebed25 100644
--- a/gnu/packages/lisp-xyz.scm
+++ b/gnu/packages/lisp-xyz.scm
@@ -119,6 +119,7 @@
   #:use-module (gnu packages web)
   #:use-module (gnu packages webkit)
   #:use-module (gnu packages xdisorg)
+  #:use-module (gnu packages xiph)
   #:use-module (gnu packages xml)
   #:use-module (gnu packages xorg)
   #:use-module (ice-9 match)
@@ -2427,6 +2428,43 @@ consistent across multiple Common Lisp implementations.")
 (define-public ecl-trivial-features
   (sbcl-package->ecl-package sbcl-trivial-features))
 
+(define-public sbcl-harmony
+  (let ((commit "0b57483cc0341936c201b620f82a8542c606991f")
+        (revision "0"))
+    (package
+      (name "sbcl-harmony")
+      (version (git-version "2.0.0" revision commit))
+      (source
+       (origin
+         (method git-fetch)
+         (uri (git-reference
+               (url "https://github.com/Shirakumo/harmony")
+               (commit commit)))
+         (file-name (git-file-name "cl-harmony" version))
+         (sha256
+          (base32 "0pqmfi3yi3gi7b7dyayrb621hp60rn7hasq0cl0fis3vg0fp5dja"))))
+      (build-system asdf-build-system/sbcl)
+      (inputs
+       (list sbcl-atomics
+             sbcl-bordeaux-threads
+             sbcl-cl-mixed
+             sbcl-stealth-mixin
+             sbcl-trivial-features))
+      (home-page "https://shirakumo.github.io/harmony/")
+      (synopsis "Common Lisp sound server and sound processing library")
+      (description
+       "HARMONY is a library that provides you with audio processing tools as
+well as an audio server to play back music, sfx, and so forth.  It is most
+suited for use in a game engine, but may feasibly also be used for more
+advanced things such as a DAW")
+      (license license:zlib))))
+
+(define-public ecl-harmony
+  (sbcl-package->ecl-package sbcl-harmony))
+
+(define-public cl-harmony
+  (sbcl-package->cl-source-package sbcl-harmony))
+
 (define-public sbcl-hu.dwim.asdf
   (let ((commit "67cdf84390e530af4303cc4bc815fdf2a5e48f59"))
     (package
@@ -6924,6 +6962,53 @@ mostly Common Lisp implementation.")
 (define-public ecl-cl-fastcgi
   (sbcl-package->ecl-package sbcl-cl-fastcgi))
 
+(define-public sbcl-cl-flac
+  (let ((commit "d094d33d3cc2cf263263b917798d338eded3c532")
+        (revision "0"))
+    (package
+      (name "sbcl-cl-flac")
+      (version (git-version "1.0.0" revision commit))
+      (source
+       (origin
+         (method git-fetch)
+         (uri (git-reference
+               (url "https://github.com/Shirakumo/cl-flac")
+               (commit commit)))
+         (file-name (git-file-name "cl-flac" version))
+         (sha256
+          (base32 "1dgr5xqf175hzq3sxpbixxia2k2g3rz0pn6msch4dnvk7a1naqlc"))
+         (modules '((guix build utils)))
+         (snippet
+          ;; Delete bundled libraries.
+          `(begin
+             (delete-file-recursively "static")))))
+      (build-system asdf-build-system/sbcl)
+      (arguments
+       `(#:phases
+         (modify-phases %standard-phases
+           (add-after 'unpack 'fix-paths
+             (lambda* (#:key inputs #:allow-other-keys)
+               (substitute* "low-level.lisp"
+                 (("libflac.so")
+                  (search-input-file inputs "/lib/libFLAC.so"))))))))
+      (inputs
+       (list flac
+             sbcl-cffi
+             sbcl-documentation-utils
+             sbcl-trivial-features
+             sbcl-trivial-garbage))
+      (home-page "https://shirakumo.github.io/cl-flac")
+      (synopsis "CFFI bindings to libflac for Common Lisp")
+      (description "This package provides CFFI bindings to the @code{libflac}
+audio library for Common Lisp.")
+      (license license:zlib))))
+
+(define-public ecl-cl-flac
+  (sbcl-package->ecl-package sbcl-cl-flac))
+
+(define-public cl-flac
+  (sbcl-package->cl-source-package sbcl-cl-flac))
+
 (define-public sbcl-clack
   (let ((commit "6fd0279424f7ba5fd4f92d69a1970846b0b11222")
         (revision "2"))
@@ -19129,6 +19214,86 @@ encodings.")
 (define-public cl-mime
   (sbcl-package->cl-source-package sbcl-cl-mime))
 
+(define-public sbcl-cl-mixed
+  (let ((commit "4aaff134d3902d93a2a8605c10de4bcfc62d7afa")
+        (revision "0"))
+    (package
+      (name "sbcl-cl-mixed")
+      (version (git-version "2.1.0" revision commit))
+      (source
+       (origin
+         (method git-fetch)
+         (uri (git-reference
+               (url "https://github.com/Shirakumo/cl-mixed")
+               (commit commit)))
+         (file-name (git-file-name "cl-mixed" version))
+         (sha256
+          (base32 "1mrj95lxb1gbxxm89x8gy1ifw2ic1p5wwpapkxcd2jr8abw7zny0"))
+         (modules '((guix build utils)))
+         (snippet
+          ;; Delete bundled libraries.
+          `(begin
+             (delete-file-recursively "static")))))
+      (build-system asdf-build-system/sbcl)
+      (arguments
+       '(#:asd-systems '("cl-mixed"
+                         "cl-mixed-examples"
+                         "cl-mixed-flac"
+                         "cl-mixed-vorbis"
+                         "cl-mixed-alsa"
+                         "cl-mixed-jack"
+                         "cl-mixed-mpg123"
+                         "cl-mixed-mpt"
+                         "cl-mixed-out123"
+                         "cl-mixed-pulse"
+                         "cl-mixed-sdl2"
+                         "cl-mixed-wav")
+         #:phases
+         (modify-phases %standard-phases
+           (add-after 'unpack 'fix-paths
+             (lambda* (#:key inputs #:allow-other-keys)
+               (substitute* "low-level.lisp"
+                 (("libmixed.so.2")
+                  (search-input-file inputs "/lib/libmixed.so.2"))))))))
+      (inputs
+       (list libmixed
+             sbcl-alexandria
+             sbcl-cffi
+             sbcl-cl-flac
+             sbcl-cl-mpg123
+             sbcl-cl-out123
+             sbcl-cl-vorbis
+             sbcl-documentation-utils
+             sbcl-sdl2
+             sbcl-static-vectors
+             sbcl-trivial-features))
+      (home-page "https://shirakumo.github.io/cl-mixed/")
+      (synopsis "Extended audio library for Common Lisp")
+      (description
+       "This package provides CFFI binding to @code{libmixed} audio library for
+Common Lisp with support of other audio formats available on GNU/Linux systems:
+
+@itemize
+
+@item @acronym{Alsa, Advanced Linux Sound Architecture}
+@item @acronym{Jack, JackAudio toolkit}
+@item @acronym{Openmpt, Libopenmpt playback drain for tracker files}
+@item @acronym{PulseAudio, PulseAudio based playback drain}
+@item Flac (via CL-FLAC)
+@item Mpg123 (via CL-MPG123)
+@item Ogg/vorbis (via CL-VORBIS)
+@item Out123 (via CL-OUT123)
+@item WAV
+
+@end itemize")
+      (license license:zlib))))
+
+(define-public ecl-cl-mixed
+  (sbcl-package->ecl-package sbcl-cl-mixed))
+
+(define-public cl-mixed
+  (sbcl-package->cl-source-package sbcl-cl-mixed))
+
 (define-public sbcl-lispbuilder-sdl
   (let ((commit "589b3c6d552bbec4b520f61388117d6c7b3de5ab"))
     (package
@@ -21283,8 +21448,7 @@ joysticks, and other such HID devices.")
                          ;; ...
                          ;; "trial-glop"
                          "trial-gltf"
-                         ;; TODO: It requires a long packaging journey.
-                         ;; "trial-harmony"
+                         "trial-harmony"
                          "trial-jpeg"
                          "trial-notify"
                          "trial-png"
@@ -21330,6 +21494,7 @@ joysticks, and other such HID devices.")
              sbcl-form-fiddle
              sbcl-glop
              sbcl-glsl-toolkit
+             sbcl-harmony
              sbcl-ieee-floats
              sbcl-jzon
              sbcl-lambda-fiddle
@@ -23959,6 +24124,67 @@ Vernacular builds on Overlord and is inspired by Racket.")
 (define-public cl-vernacular
   (sbcl-package->cl-source-package sbcl-vernacular))
 
+(define-public sbcl-cl-collider
+  (let ((commit "a46908896982868955b29bfb3a5337a0af489b0b")
+        (revision "0"))
+    (package
+     (name "sbcl-cl-collider")
+     (version (git-version "2018.7.15" revision commit))
+     (source
+       (origin
+         (method git-fetch)
+         (uri (git-reference
+               (url "https://github.com/byulparan/cl-collider")
+               (commit commit)))
+         (file-name (git-file-name "cl-collider" version))
+         (sha256
+          (base32 "10wvjbwvbgr0b57hpfxycg90yjmb29pirygr1sxrdaqxll328sz1"))))
+     (build-system asdf-build-system/sbcl)
+     (arguments
+       (list #:phases
+             #~(modify-phases %standard-phases
+                 (add-after 'unpack 'patch-executables-and-paths
+                   (lambda* (#:key inputs #:allow-other-keys)
+                     (substitute* "server.lisp"
+                       (("/usr/local/lib/SuperCollider/plugins")
+                        (search-input-directory
+                         inputs "/lib/SuperCollider/plugins"))
+                       (("/usr/local/share/SuperCollider/Extensions")
+                        (search-input-directory
+                         inputs "/share/SuperCollider/Extensions"))
+                       (("which scsynth")
+                        (string-append
+                         "which "
+                         (search-input-file inputs "/bin/scsynth")))
+                       (("jack_connect")
+                        (search-input-file inputs "/bin/jack_connect"))))))))
+     (inputs
+       (list jack-1
+             supercollider
+             sbcl-alexandria
+             sbcl-bordeaux-threads
+             sbcl-cffi
+             sbcl-cl-ppcre
+             sbcl-flexi-streams
+             sbcl-ieee-floats ; sc-osc dependencies.
+             sbcl-named-readtables
+             sbcl-osc
+             sbcl-pileup
+             sbcl-simple-inferiors ; For ecl.
+             sbcl-split-sequence
+             sbcl-usocket))
+     (synopsis "SuperCollider client for CommonLisp")
+     (description "This package provides a SuperCollider client for
+Common Lisp.")
+     (home-page "https://github.com/byulparan/cl-collider/")
+     (license license:public-domain))))
+
+(define-public cl-collider
+  (sbcl-package->cl-source-package sbcl-cl-collider))
+
+(define-public ecl-cl-collider
+  (sbcl-package->ecl-package sbcl-cl-collider))
+
 (define-public sbcl-osc
   (let ((commit "9f0a9d3da310a3a0f654f48af0203816f3f371ad")
         (revision "0"))
@@ -28033,6 +28259,57 @@ generation as well as numerous distributions.")
 (define-public ecl-cl-variates
   (sbcl-package->ecl-package sbcl-cl-variates))
 
+(define-public sbcl-cl-vorbis
+  (let ((commit "c5835cd7091aea9e2e389ad359d244542d637758")
+        (revision "0"))
+    (package
+      (name "sbcl-cl-vorbis")
+      (version (git-version "1.0.0" revision commit))
+      (source
+       (origin
+         (method git-fetch)
+         (uri (git-reference
+               (url "https://github.com/Shirakumo/cl-vorbis")
+               (commit commit)))
+         (file-name (git-file-name "cl-vorbis" version))
+         (sha256
+          (base32 "0713pl5c2khfpf8m3h1l2y0ilack7akf580h70jq6qcrnq3h4b40"))
+         (modules '((guix build utils)))
+         (snippet
+          ;; Delete bundled libraries, GlibC and Vorbis sources.
+          `(begin
+             (delete-file-recursively "static")
+             (for-each delete-file '("glibc-2.13.h"
+                                     "stb_vorbis.c"
+                                     "stb_vorbis_patch.c"))))))
+      (build-system asdf-build-system/sbcl)
+      (arguments
+       `(#:phases
+         (modify-phases %standard-phases
+           (add-after 'unpack 'fix-paths
+             (lambda* (#:key inputs #:allow-other-keys)
+               (substitute* "low-level.lisp"
+                 (("libvorbis-lin-amd64.so")
+                  (search-input-file inputs "/lib/libvorbis.so"))))))))
+      (inputs
+       (list libvorbis
+             sbcl-cffi
+             sbcl-documentation-utils
+             sbcl-static-vectors
+             sbcl-trivial-features
+             sbcl-trivial-garbage))
+      (home-page "https://shirakumo.github.io/cl-vorbis/")
+      (synopsis "OGG/Vorbis decoding using stb_vorbis for Common Lisp")
+      (description "This package provides CFFI bindings for the
+@code{stb_vorbis} audio library to Common Lisp.")
+      (license license:zlib))))
+
+(define-public ecl-cl-vorbis
+  (sbcl-package->ecl-package sbcl-cl-vorbis))
+
+(define-public cl-vorbis
+  (sbcl-package->cl-source-package sbcl-cl-vorbis))
+
 (define-public sbcl-cephes
   (let ((commit "d87146fa38c8425ffb5fe425eee5eb3e818bacd4")
         (revision "0"))
diff --git a/gnu/packages/maths.scm b/gnu/packages/maths.scm
index a304d4befa..286532fa70 100644
--- a/gnu/packages/maths.scm
+++ b/gnu/packages/maths.scm
@@ -5218,6 +5218,95 @@ packages.")
     ;;  GPUQREngine, RBio, SuiteSparse_GPURuntime, SuiteSparseQR, UMFPACK
     (license (list license:gpl2+ license:lgpl2.1+))))
 
+
+;; This outdated version is used to build the scilab package.
+(define-public suitesparse-3
+  (package
+    (inherit suitesparse)
+    (name "suitesparse")
+    (version "3.1.0")
+    (source
+     (origin
+       (method git-fetch)
+       (uri (git-reference
+             (url "https://github.com/DrTimothyAldenDavis/SuiteSparse")
+             (commit (string-append "v" version))))
+       (file-name (git-file-name name version))
+       (sha256
+        (base32 "0wxk755nzps0c9la24zqknqkzjp6rcj5q9jhd973mff1pqja3clz"))))
+    (build-system gnu-build-system)
+    (arguments
+     `(#:tests? #f  ;no "check" target
+       #:make-flags
+       ,#~(list
+           (string-append "CC=gcc")
+           "AR=gcc -shared -o"
+           "RANLIB=touch"
+           "CFLAGS=-O3 -fPIC -I../Include"
+           "TBB=-ltbb"
+
+           ;; Disable metis@4 (nonfree) support.
+           "CHOLMOD_CONFIG=-DNPARTITION"
+           "METIS="
+           "METIS_PATH="
+
+           ;; The default is to link against netlib lapack.  Use OpenBLAS
+           ;; instead.
+           "BLAS=-lopenblas" "LAPACK=-lopenblas"
+
+           (string-append "INSTALL_LIB="
+                          (assoc-ref %outputs "out") "/lib")
+           (string-append "INSTALL_INCLUDE="
+                          (assoc-ref %outputs "out") "/include")
+           "library")
+       #:phases
+       (modify-phases %standard-phases
+         (add-after 'unpack 'correct-build-configuration
+           (lambda _
+             ;; Invert build order: CHOLMOD before KLU.
+             (substitute* "Makefile"
+               (("\t\\( cd CHOLMOD ; \\$\\(MAKE\\) \\)\n$")
+                "")
+               (("\\( cd KLU ; \\$\\(MAKE\\) \\)")
+                (string-append "( cd CHOLMOD ; $(MAKE) )\n\t"
+                               "( cd KLU ; $(MAKE) )")))
+             ;; Build shared libraries.
+             (substitute* (find-files "." "akefile$")
+               (("lib([a-z]+)\\.a" all libname)
+                (string-append "lib" libname ".so")))
+             ;; Delete broken KLU Demo step.
+             (substitute* "KLU/Makefile"
+               (("\\( cd Demo ; \\$\\(MAKE\\) \\)")
+                ""))))
+         (replace 'install
+           (lambda _
+             ;; Install libraries.
+             (for-each
+              (lambda (x)
+                (install-file
+                 x
+                 (string-append (assoc-ref %outputs "out") "/lib")))
+              (find-files "." "\\.so$"))
+             ;; Install header files.
+             (for-each
+              (lambda (x)
+                (install-file
+                 x
+                 (string-append (assoc-ref %outputs "out") "/include")))
+              (find-files "." "\\.h$"))))
+         ,@(if (target-riscv64?)
+               ;; GraphBLAS FTBFS on riscv64-linux
+               `((add-after 'unpack 'skip-graphblas
+                   (lambda _
+                     (substitute* "Makefile"
+                       ((".*cd GraphBLAS.*") "")
+                       (("metisinstall gbinstall moninstall")
+                        "moninstall")))))
+               '())
+         (delete 'configure))))         ;no configure script
+    (inputs
+     (list tbb openblas gmp mpfr))))
+
 (define-public atlas
   (package
     (name "atlas")
@@ -6072,6 +6161,14 @@ structured and unstructured grid problems.")))
         (base32
          "0vr8c1mz1k6mz0sgh6n3scl5c3a71iqmy5fnydrgq504icj4vym4"))))
     (build-system gnu-build-system)
+    (arguments
+     (list
+      #:phases
+      #~(modify-phases %standard-phases
+          (add-before 'install 'install-matioConfig.h
+            (lambda _
+              (install-file "src/matioConfig.h"
+                            (string-append #$output "/include")))))))
     (inputs
      (list zlib hdf5-1.8))
     (home-page "http://matio.sourceforge.net/")
@@ -8569,3 +8666,109 @@ primal-dual interior-point method are made available.  Interfaces are
 provided for applications written in C++ and Python.  Parallel
 computation is supported via MPI.")
     (license license:bsd-2))))
+
+(define-public scilab
+  (package
+    (name "scilab")
+    (version "5.5.0")
+    (source
+     (origin
+       (method url-fetch)
+       (uri
+        (string-append "https://oos.eu-west-2.outscale.com/scilab-releases/"
+                       version "/scilab-" version "-src.tar.gz"))
+       (sha256
+        (base32 "1hx57aji5d78brwqcf8a34i1hasm3h4nw46xjg7cgxj09s8yz5kq"))))
+    (build-system gnu-build-system)
+    (native-inputs (list pkg-config gfortran))
+    (inputs (list libxml2
+                  `(,pcre "bin")
+                  `(,pcre "out")
+                  readline
+                  hdf5-1.8
+                  curl
+                  openblas
+                  lapack
+                  arpack-ng
+                  fftw
+                  gettext-minimal
+                  suitesparse-3
+                  tcl
+                  tk
+                  libx11
+                  matio))
+    (arguments
+     `(#:tests? #f
+       #:configure-flags
+       ,#~(list
+           "--enable-relocatable"
+           "--disable-static-system-lib"
+           ;; Disable all java code.
+           "--without-gui"
+           "--without-javasci"
+           "--disable-build-help"
+           "--with-external-scirenderer"
+           ;; Tcl and Tk library locations.
+           (string-append "--with-tcl-include="
+                          (string-drop-right
+                           (search-input-file %build-inputs "include/tcl.h")
+                           (string-length "/tcl.h")))
+           (string-append "--with-tcl-library="
+                          (string-drop-right
+                           (search-input-directory %build-inputs "lib/tcl8")
+                           (string-length "/tcl8")))
+           (string-append "--with-tk-include="
+                          (string-drop-right
+                           (search-input-file %build-inputs "include/tk.h")
+                           (string-length "/tk.h")))
+           (string-append "--with-tk-library="
+                          (string-drop-right
+                           (search-input-directory %build-inputs "lib/tk8.6")
+                           (string-length "/tk8.6")))
+           ;; There are some 2018-fortran errors that are ignored
+           ;; with this fortran compiler flag.
+           "FFLAGS=-fallow-argument-mismatch")
+       #:phases
+       ,#~(modify-phases %standard-phases
+            (add-before 'build 'pre-build
+              (lambda _
+                ;; Fix scilab script.
+                (substitute* "bin/scilab"
+                  (("\\/bin\\/ls")
+                   (which "ls")))
+                ;; Fix core.start.
+                (substitute* "modules/core/etc/core.start"
+                  (("'SCI/modules")
+                   "SCI+'/modules"))
+                ;; Fix fortran compilation error.
+                (substitute*
+                    "modules/differential_equations/src/fortran/twodq.f"
+                  (("node\\(10\\),node1\\(10\\),node2\\(10\\),coef")
+                   "node(9),node1(9),node2(9),coef"))
+                ;; Fix C compilation errors.
+                ;; remove &
+                (substitute* "modules/hdf5/src/c/h5_readDataFromFile_v1.c"
+                  (("(H5Rdereference\\(_iDatasetId, H5R_OBJECT, )&(.*)\\);$"
+                    all common ref)
+                   (string-append common ref)))
+                ;; fix multiple definitions
+                (substitute* "modules/tclsci/src/c/TCL_Command.h"
+                  (("^__thread")
+                   "extern __thread"))
+                (substitute* "modules/tclsci/src/c/InitTclTk.c"
+                  (("BOOL TK_Started = FALSE;" all)
+                   (string-append all "\n"
+                                  "__threadId TclThread;" "\n"
+                                  "__threadSignal InterpReady;" "\n"
+                                  "__threadSignalLock InterpReadyLock;"
+                                  "\n")))
+                ;; Set SCIHOME to /tmp before macros compilation.
+                (setenv "SCIHOME" "/tmp"))))))
+    (home-page "https://scilab.org")
+    (synopsis "Software for engineers and scientists")
+    (description "This package provides the non-graphical version of the Scilab
+software for engineers and scientists. Scilab is used for signal processing,
+statistical analysis, image enhancement, fluid dynamics simulations, numerical
+optimization, and modeling, simulation of explicit and implicit dynamical
+systems and symbolic manipulations.")
+    (license license:cecill)))                    ;CeCILL v2.1
diff --git a/gnu/packages/package-management.scm b/gnu/packages/package-management.scm
index 537d01e164..29cb481862 100644
--- a/gnu/packages/package-management.scm
+++ b/gnu/packages/package-management.scm
@@ -1137,7 +1137,7 @@ written entirely in Python.")
 (define-public conan
   (package
     (name "conan")
-    (version "1.50.0")
+    (version "2.0.2")
     (source
      (origin
        (method git-fetch)               ;no tests in PyPI archive
@@ -1147,104 +1147,113 @@ written entirely in Python.")
        (file-name (git-file-name name version))
        (sha256
         (base32
-         "1jjrinz5wkcxfvwdpldrv4h7vacdyz88cc4af5vi3sdnjra0i0m5"))))
+         "1y4qmqnw3s8xv64lgp388qpj9vqharyfqi5s8dxvgsns6cafv7lf"))))
     (build-system python-build-system)
     (arguments
-     `(#:phases
-       (modify-phases %standard-phases
-         (add-after 'unpack 'relax-requirements
-           (lambda _
-             (substitute* "conans/requirements.txt"
-               (("node-semver==0.6.1")
-                "node-semver>=0.6.1")
-               (("Jinja2>=2.9, <3")
-                "Jinja2>=2.9")
-               (("PyYAML>=3.11, <6.0")
-                "PyYAML"))))
-         (add-after 'unpack 'patch-paths
-           (lambda* (#:key inputs #:allow-other-keys)
-             (let ((coreutils (assoc-ref inputs "coreutils")))
-               ;; It seems that PATH is manipulated, as printenv is not found
-               ;; during tests.  Patch in its exact location.
-               (substitute* "conan/tools/env/environment.py"
-                 (("printenv")
-                  (string-append coreutils "/bin/printenv")))
-               (substitute* "conans/client/envvars/environment.py"
-                 (("#!/usr/bin/env")
-                  (string-append "#!" coreutils "/bin/env"))))))
-         (add-before 'check 'set-home
-           (lambda _
-             (setenv "HOME" "/tmp")))
-         (replace 'check
-           (lambda* (#:key tests? outputs #:allow-other-keys)
-             (define system ,(or (%current-target-system)
-                                 (%current-system)))
-             (when tests?
-               (setenv "PATH" (string-append (getenv "PATH") ":"
-                                             (assoc-ref outputs "out") "/bin"))
-               (invoke "python" "-m" "pytest"
-                       "-n" "auto"      ;parallelize tests
-                       "-m" "not slow and not tool_svn"
-                       ;; Disable problematic tests.
-                       "-k"
-                       (string-append
-                        ;; These tests rely on networking.
-                        "not shallow_clone_remote "
-                        "and not remote_build "
-                        "and not download_retries_errors "
-                        "and not ftp "
-                        "and not build_local_different_folders "
-                        ;; These expect CMake available at fixed versions.
-                        "and not custom_cmake "
-                        "and not default_cmake "
-                        "and not bazel " ;bazel is not packaged
-                        ;; Guix sets PKG_CONFIG_PATH itself, which is not
-                        ;; expected by the following test.
-                        "and not pkg_config_path "
-                        "and not compare " ;caused by newer node-semver?
-                        ;; Guix is not currently a supported package manager.
-                        "and not system_package_tool "
-                        ;; These expect GCC 5 to be available.
-                        "and not test_reuse "
-                        "and not test_install "
-                        ;; The installed configure script trips on the /bin/sh
-                        ;; shebang.  We'd have to patch it in the Python code.
-                        "and not test_autotools "
-                        "and not test_use_build_virtualenv "
-                        ;; This test is architecture-dependent.
-                        "and not test_toolchain_linux "
-                        ;; This one fails for unknown reasons (see:
-                        ;; https://github.com/conan-io/conan/issues/9671).
-                        "and not test_build "
-                        ;; These tests expect the 'apt' command to be available.
-                        "and not test_apt_check "
-                        "and not test_apt_install_substitutes "
-                        (if (not (string-prefix? "x86_64" system))
-                            ;; These tests either assume the machine is
-                            ;; x86_64, or require a cross-compiler to target
-                            ;; it.
-                            (string-append
-                             "and not cpp_package "
-                             "and not exclude_code_analysis "
-                             "and not cmakedeps_multi "
-                             "and not locally_build_linux "
-                             "and not custom_configuration "
-                             "and not package_from_system "
-                             "and not cross_build_command "
-                             "and not test_package "
-                             "and not test_deleted_os "
-                             "and not test_same ")
-                            "")
-                        (if (not (or (string-prefix? "x86_64" system)
-                                     (string-prefix? "i686" system)))
-                            ;; These tests either assume the machine is i686,
-                            ;; or require a cross-compiler to target it.
-                            (string-append
-                             "and not vcvars_raises_when_not_found "
-                             "and not conditional_generators "
-                             "and not test_folders "
-                             "and not settings_as_a_dict_conanfile ")
-                            "")))))))))
+     (list
+      #:modules '((guix build python-build-system)
+                  (guix build utils)
+                  (ice-9 format))
+      #:phases
+      #~(modify-phases %standard-phases
+          (add-after 'unpack 'patch-paths
+            (lambda* (#:key inputs #:allow-other-keys)
+              ;; It seems that PATH is manipulated, as printenv is not found
+              ;; during tests.  Patch in its exact location.
+              (substitute* "conan/tools/env/environment.py"
+                (("printenv")
+                 (search-input-file inputs "bin/printenv")))))
+          (add-after 'unpack 'patch-hard-coded-GCC-references
+            (lambda _
+              ;; The test suite expects GCC 9 to be used (see:
+              ;; https://github.com/conan-io/conan/issues/13575).  Render the
+              ;; check version agnostic.
+              (substitute* "conans/test/functional/toolchains/meson/_base.py"
+                (("__GNUC__9")
+                 "__GNUC__"))))
+          (add-after 'unpack 'use-current-cmake-for-tests
+            (lambda _
+              (substitute* (find-files "conans/test" "\\.py$")
+                (("@pytest.mark.tool\\(\"cmake\", \"3.23\")")
+                 "@pytest.mark.tool(\"cmake\")"))))
+          (add-before 'check 'configure-tests
+            (lambda _
+              (let* ((cmake-version #$(version-major+minor
+                                       (package-version cmake)))
+                     (pkg-config-version #$(version-major+minor
+                                            (package-version pkg-config))))
+                (call-with-output-file "conans/test/conftest_user.py"
+                  (lambda (port)
+                    (format port "\
+tools_locations = {
+    'apt_get': {'disabled': True},
+    'bazel': {'disabled': True},
+    'cmake': {'default': '~a',
+              '3.15': {'disabled': True},
+              '3.16': {'disabled': True},
+              '3.17': {'disabled': True},
+              '3.19': {'disabled': True},
+              '~:*~a': {}},
+    'pkg_config': {'exe': 'pkg-config',
+                   'default': '~a',
+                   '~:*~a': {}},
+    'svn': {'disabled': True}}~%" cmake-version pkg-config-version))))))
+          (add-before 'check 'set-home
+            (lambda _
+              (setenv "HOME" "/tmp")))
+          (replace 'check
+            (lambda* (#:key tests? outputs #:allow-other-keys)
+              (define system #$(or (%current-target-system)
+                                   (%current-system)))
+              (when tests?
+                (setenv "CONFIG_SHELL" (which "sh"))
+                (setenv "PATH" (string-append (getenv "PATH") ":"
+                                              #$output "/bin"))
+                (invoke "python" "-m" "pytest" "-vv"
+                        "-n" (number->string (parallel-job-count))
+                        "-m" "not slow"
+                        ;; Disable problematic tests.
+                        "-k"
+                        (string-append
+                         ;; These tests rely on networking.
+                         "not download_retries_errors "
+                         "and not ftp "
+                         ;; Guix sets PKG_CONFIG_PATH itself, which is not
+                         ;; expected by the following test.
+                         "and not pkg_config_path "
+                         "and not compare " ;caused by newer node-semver?
+                         ;; This test hard-codes a compiler version.
+                         "and not test_toolchain "
+                         ;; The 'test_list' tests may fail
+                         ;; non-deterministically (see:
+                         ;; https://github.com/conan-io/conan/issues/13583).
+                         "and not test_list "
+                         ;; These tests fail when Autoconf attempt to load a
+                         ;; shared library in the same directory (see:
+                         ;; https://github.com/conan-io/conan/issues/13577).
+                         "and not test_other_client_can_link_autotools "
+                         "and not test_autotools_lib_template "
+                         (if (not (string-prefix? "x86_64" system))
+                             ;; These tests either assume the machine is
+                             ;; x86_64, or require a cross-compiler to target
+                             ;; it.
+                             (string-append
+                              "and not cpp_package "
+                              "and not exclude_code_analysis "
+                              "and not cmakedeps_multi "
+                              "and not locally_build_linux "
+                              "and not custom_configuration "
+                              "and not package_from_system "
+                              "and not cross_build_command "
+                              "and not test_package "
+                              "and not test_same ")
+                             "")
+                         (if (not (or (string-prefix? "x86_64" system)
+                                      (string-prefix? "i686" system)))
+                             ;; This test only works with default arch "x86",
+                             ;; "x86_64", "sparc" or "sparcv9".
+                             "and not settings_as_a_dict_conanfile "
+                             "")))))))))
     (propagated-inputs
      (list python-bottle
            python-colorama
@@ -1264,22 +1273,23 @@ written entirely in Python.")
            python-tqdm
            python-urllib3))
     (inputs
-     (list coreutils))       ;for printenv
+     (list coreutils))                  ;for printenv
     (native-inputs
-     `(("autoconf" ,autoconf)
-       ("automake" ,automake)
-       ("cmake" ,cmake)
-       ("git" ,git-minimal)
-       ("meson" ,meson)
-       ("ninja",ninja)
-       ("pkg-config" ,pkg-config)
-       ("python-bottle" ,python-bottle)
-       ("python-mock" ,python-mock)
-       ("python-parameterized" ,python-parameterized)
-       ("python-pytest" ,python-pytest)
-       ("python-pytest-xdist" ,python-pytest-xdist)
-       ("python-webtest" ,python-webtest)
-       ("which" ,which)))
+     (list autoconf-wrapper
+           automake
+           cmake
+           git-minimal
+           libtool
+           meson
+           ninja
+           pkg-config
+           python-bottle
+           python-mock
+           python-parameterized
+           python-pytest
+           python-pytest-xdist
+           python-webtest
+           which))
     (home-page "https://conan.io")
     (synopsis "Decentralized C/C++ package manager")
     (description "Conan is a package manager for C and C++ developers that
diff --git a/gnu/packages/python-crypto.scm b/gnu/packages/python-crypto.scm
index c9071c4cf6..c3e36ff2e4 100644
--- a/gnu/packages/python-crypto.scm
+++ b/gnu/packages/python-crypto.scm
@@ -1503,21 +1503,14 @@ items and collections, editing items, locking and unlocking collections
 (define-public python-trustme
   (package
     (name "python-trustme")
-    (version "0.6.0")
+    (version "0.9.0")
     (source
      (origin
        (method url-fetch)
        (uri (pypi-uri "trustme" version))
        (sha256
-        (base32 "0v3vr5z6apnfmklf07m45kv5kaqvm6hxrkaqywch57bjd2siiywx"))))
-    (build-system python-build-system)
-    (arguments
-     `(#:phases
-       (modify-phases %standard-phases
-         (replace 'check
-           (lambda* (#:key inputs outputs #:allow-other-keys)
-             (add-installed-pythonpath inputs outputs)
-             (invoke "pytest" "-vv"))))))
+        (base32 "0v2qzszmyazfgc1snicdr4b4qdajpjd4pbinpgrn9vfff0yv41sy"))))
+    (build-system pyproject-build-system)
     (native-inputs
      (list python-more-itertools
            python-pyopenssl
@@ -1526,7 +1519,9 @@ items and collections, editing items, locking and unlocking collections
            python-service-identity
            python-zipp))
     (propagated-inputs
-     (list python-cryptography))
+     (list python-cryptography
+           python-idna
+           python-ipaddress))
     (home-page "https://github.com/python-trio/trustme")
     (synopsis "Fake a certificate authority for tests")
     (description
diff --git a/gnu/packages/python-web.scm b/gnu/packages/python-web.scm
index d186653544..d84b5efdf9 100644
--- a/gnu/packages/python-web.scm
+++ b/gnu/packages/python-web.scm
@@ -49,7 +49,7 @@
 ;;; Copyright © 2021 Alice Brenon <alice.brenon@ens-lyon.fr>
 ;;; Copyright © 2022 John Kehayias <john.kehayias@protonmail.com>
 ;;; Copyright © 2022 Denis 'GNUtoo' Carikli <GNUtoo@cyberdimension.org>
-;;; Copyright © 2022 Felix Gruber <felgru@posteo.net>
+;;; Copyright © 2022, 2023 Felix Gruber <felgru@posteo.net>
 ;;; Copyright © 2022 Peter Polidoro <peter@polidoro.io>
 ;;; Copyright © 2022 Antero Mejr <antero@mailbox.org>
 ;;; Copyright © 2022 Luis Henrique Gomes Higino <luishenriquegh2701@gmail.com>
@@ -570,6 +570,87 @@ communicate with each other, and positioned as an asynchronous successor to
 WSGI.  This package includes libraries for implementing ASGI servers.")
     (license license:bsd-3)))
 
+(define-public python-asgi-csrf
+  (package
+    (name "python-asgi-csrf")
+    (version "0.9")
+    (source (origin
+              (method git-fetch)        ;for tests
+              (uri (git-reference
+                    (url "https://github.com/simonw/asgi-csrf")
+                    (commit version)))
+              (file-name (git-file-name name version))
+              (sha256
+               (base32
+                "1j134mjh0ff61rvkm3q67m463j1bhyxc9dwsdany3scnd4vsqqws"))))
+    (build-system pyproject-build-system)
+    (arguments
+     (list #:test-flags
+           ;; Provide a null config to avoid the extraneous dependency on
+           ;; python-pytest-coverage.
+           #~(list "-c" "/dev/null"
+                   ;; Disable two failing tests (see:
+                   ;; https://github.com/simonw/asgi-csrf/issues/24).
+                   "-k" (string-append
+                         "not (test_multipart "
+                         "or test_multipart_failure_wrong_token)"))))
+    (propagated-inputs (list python-itsdangerous python-multipart))
+    (native-inputs (list python-asgi-lifespan
+                         python-httpx
+                         python-pytest
+                         python-pytest-asyncio
+                         python-starlette))
+    (home-page "https://github.com/simonw/asgi-csrf")
+    (synopsis "ASGI middleware for protecting against CSRF attacks")
+    (description "This Asynchronous Server Gateway Interface (ASGI)
+middleware protects against Cross-site request forgery (CSRF) attacks.
+It implements the Double Submit Cookie pattern, where a cookie is set
+that is then compared to a @code{csrftoken} hidden form field or a
+@code{x-csrftoken} HTTP header.")
+    (license license:asl2.0)))
+
+(define-public python-asgi-lifespan
+  (package
+    (name "python-asgi-lifespan")
+    (version "1.0.1")
+    (source (origin
+              (method git-fetch)        ;for tests
+              (uri (git-reference
+                    (url "https://github.com/florimondmanca/asgi-lifespan")
+                    (commit version)))
+              (file-name (git-file-name name version))
+              (sha256
+               (base32
+                "10a5ci9ddr8wnjf3wai7xifbbplirhyrgvw4p28q0ha63cvhb2j2"))))
+    (build-system pyproject-build-system)
+    (arguments
+     (list
+      #:test-flags
+      '(list "-c" "/dev/null"           ;ignore coverage-related options
+             "-k"
+             (string-append
+              ;; XXX: Some tests fail because of a 'lifespan.shutdown.failed'
+              ;; extra event, perhaps because our version of trio is older.
+              "not (test_lifespan_manager[asyncio-None-ValueError-None]"
+              " or test_lifespan_manager[asyncio-ValueError-None-None]"
+              " or test_lifespan_manager[asyncio-ValueError-ValueError-None]"
+              " or test_lifespan_manager[trio-None-ValueError-None]"
+              " or test_lifespan_manager[trio-ValueError-None-None]"
+              " or test_lifespan_manager[trio-ValueError-ValueError-None])"))))
+    (native-inputs (list python-pytest
+                         python-pytest-asyncio
+                         python-pytest-trio
+                         python-starlette))
+    (propagated-inputs (list python-sniffio))
+    (home-page "https://github.com/florimondmanca/asgi-lifespan")
+    (synopsis "Programmatic startup/shutdown of ASGI apps")
+    (description "Programmatically send startup/shutdown lifespan events
+into Asynchronous Server Gateway Interface (ASGI) applications.  When
+used in combination with an ASGI-capable HTTP client such as HTTPX, this
+allows mocking or testing ASGI applications without having to spin up an
+ASGI server.")
+    (license license:expat)))
+
 (define-public python-css-html-js-minify
   (package
     (name "python-css-html-js-minify")
diff --git a/gnu/packages/python-xyz.scm b/gnu/packages/python-xyz.scm
index bf29f4d4b0..85105ce00a 100644
--- a/gnu/packages/python-xyz.scm
+++ b/gnu/packages/python-xyz.scm
@@ -31635,6 +31635,24 @@ GeoJSON to WKT/WKB (Well-Known Text/Binary) or GeoPackage Binary, and vice
 versa.  Extended WKB/WKT are also supported.")
     (license license:asl2.0)))
 
+(define-public python-cogapp
+  (package
+    (name "python-cogapp")
+    (version "3.3.0")
+    (source (origin
+              (method url-fetch)
+              (uri (pypi-uri "cogapp" version))
+              (sha256
+               (base32
+                "1c0xx3p3lzrlyqhmccyq9c50f8v9pqk2992gb4nl50h2yy1m3s8v"))))
+    (build-system pyproject-build-system)
+    (native-inputs (list python-pytest))
+    (home-page "https://nedbatchelder.com/code/cog")
+    (synopsis "Content generation tool that leverages Python")
+    (description "Cog is a file generation tool.  It allows using pieces of
+Python code as generators in your source files to generate arbitrary text.")
+    (license license:expat)))
+
 (define-public python-bsdiff4
   (package
     (name "python-bsdiff4")
diff --git a/gnu/packages/shellutils.scm b/gnu/packages/shellutils.scm
index 277d2d2647..20d246be52 100644
--- a/gnu/packages/shellutils.scm
+++ b/gnu/packages/shellutils.scm
@@ -15,6 +15,7 @@
 ;;; Copyright © 2021 Foo Chuan Wei <chuanwei.foo@hotmail.com>
 ;;; Copyright © 2021 Wiktor Żelazny <wzelazny@vurv.cz>
 ;;; Copyright © 2022 Jose G Perez Taveras <josegpt27@gmail.com>
+;;; Copyright © 2023 Timo Wilken <guix@twilken.net>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -221,6 +222,60 @@ in Zsh intelligently.")
 as you type.")
     (license license:expat)))
 
+(define-public zsh-completions
+  (package
+    (name "zsh-completions")
+    (version "0.34.0")
+    (home-page "https://github.com/zsh-users/zsh-completions")
+    (source (origin
+              (method git-fetch)
+              (uri (git-reference
+                    (url home-page)
+                    (commit version)))
+              (file-name (git-file-name name version))
+              (sha256
+               (base32
+                "0jjgvzj3v31yibjmq50s80s3sqi4d91yin45pvn3fpnihcrinam9"))))
+    (build-system copy-build-system)
+    (arguments
+     '(#:install-plan '(("src/" "share/zsh/site-functions/")
+                        ("README.md" "share/doc/zsh-completions/"))))
+    (synopsis "Additional completion definitions for Zsh")
+    (description
+     "This projects aims at gathering/developing new completion scripts that
+are not available in Zsh yet.  The scripts may be contributed to the Zsh
+project when stable enough.")
+    (license (license:non-copyleft "file://LICENSE"
+              "Custom BSD-like, permissive, non-copyleft license."))))
+
+(define-public zsh-history-substring-search
+  (package
+    (name "zsh-history-substring-search")
+    (version "1.0.2")
+    (home-page "https://github.com/zsh-users/zsh-history-substring-search")
+    (source (origin
+              (method git-fetch)
+              (uri (git-reference
+                    (url home-page)
+                    (commit (string-append "v" version))))
+              (file-name (git-file-name name version))
+              (sha256
+               (base32
+                "0y8va5kc2ram38hbk2cibkk64ffrabfv1sh4xm7pjspsba9n5p1y"))))
+    (build-system copy-build-system)
+    (arguments
+     '(#:install-plan '(("zsh-history-substring-search.plugin.zsh"
+                         "share/zsh/plugins/zsh-history-substring-search/")
+                        ("zsh-history-substring-search.zsh"
+                         "share/zsh/plugins/zsh-history-substring-search/")
+                        ("README.md" "share/doc/zsh-history-substring-search/"))))
+    (synopsis "ZSH port of Fish history search (up arrow)")
+    (description
+     "This is a clean-room implementation of the Fish shell's history search
+feature, where you can type in any part of any command from history and then
+press chosen keys, such as the UP and DOWN arrows, to cycle through matches.")
+    (license license:bsd-3)))
+
 (define-public zsh-syntax-highlighting
   (package
     (name "zsh-syntax-highlighting")
diff --git a/gnu/packages/statistics.scm b/gnu/packages/statistics.scm
index a5ea61b5de..93459f8051 100644
--- a/gnu/packages/statistics.scm
+++ b/gnu/packages/statistics.scm
@@ -1299,14 +1299,14 @@ agnes cluster diagrams.")
 (define-public r-gdtools
   (package
     (name "r-gdtools")
-    (version "0.3.2")
+    (version "0.3.3")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "gdtools" version))
        (sha256
         (base32
-         "0dji1iyf6x9vg6gjklzkb3x9vfydfi95idkvckj6208b1rwgwsj4"))))
+         "10rlx1ciyvh0ayic03kckv360idl9s1zyc2ar5lisns786c1hnns"))))
     (build-system r-build-system)
     (native-inputs
      (list pkg-config))
@@ -1317,7 +1317,6 @@ agnes cluster diagrams.")
            r-fontquiver
            r-gfonts
            r-htmltools
-           r-memoise
            r-rcpp
            r-systemfonts))
     (home-page "https://cran.r-project.org/web/packages/gdtools")
@@ -1816,13 +1815,13 @@ and printing capabilities than traditional data frames.")
 (define-public r-dplyr
   (package
     (name "r-dplyr")
-    (version "1.1.0")
+    (version "1.1.1")
     (source (origin
               (method url-fetch)
               (uri (cran-uri "dplyr" version))
               (sha256
                (base32
-                "1msfp29lbddwdv8ibc2nkan0g1g4y4w5fws6802v6h6x95g57c4c"))))
+                "1xxvspk1nyns39dp2fqvxbvvnkkz4rcgmhrcrznr3h1qpayj9p6z"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-cli
@@ -1853,14 +1852,14 @@ database.")
 (define-public r-dbplyr
   (package
     (name "r-dbplyr")
-    (version "2.3.1")
+    (version "2.3.2")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "dbplyr" version))
        (sha256
         (base32
-         "0a5cnh0fr81mak9ccqr91nsjqlxsnf6a2lmwrsgv7g1sjag0b4p1"))))
+         "1b3zf2ai4kp96wd6i4jg9b3n37bwbw7lfvxvs1i1kcn6brch1p0d"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-blob
@@ -2649,17 +2648,17 @@ were originally a part of the r-devtools package.")
 (define-public r-hms
   (package
     (name "r-hms")
-    (version "1.1.2")
+    (version "1.1.3")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "hms" version))
        (sha256
         (base32
-         "1vdx08irnh8q5232hriv47hh88hc55nbbrff7y6zbainff2akrhy"))))
+         "10h2k5j97fggq3hc0qzxv1q9821y21m326v3x99zsvpl1b3g89p6"))))
     (build-system r-build-system)
     (propagated-inputs
-     (list r-ellipsis r-lifecycle r-pkgconfig r-rlang r-vctrs))
+     (list r-lifecycle r-pkgconfig r-rlang r-vctrs))
     (home-page "https://github.com/rstats-db/hms")
     (synopsis "Pretty time of day")
     (description
@@ -2857,18 +2856,19 @@ certain criterion, e.g., it contains a certain regular file.")
 (define-public r-rmarkdown
   (package
     (name "r-rmarkdown")
-    (version "2.20")
+    (version "2.21")
     (source
       (origin
         (method url-fetch)
         (uri (cran-uri "rmarkdown" version))
         (sha256
-          (base32 "178mc3dqm11y58k8jdhm1yi11bbl1h7bls9d8f94ngmlzjdhbxyp"))))
+          (base32 "0a5czn18clfnw0a9nd5v98ah4h47i32423s6jdf126ni4aj20ny2"))))
     (properties `((upstream-name . "rmarkdown")))
     (build-system r-build-system)
     (propagated-inputs
      (list r-bslib
            r-evaluate
+           r-fontawesome
            r-htmltools
            r-jquerylib
            r-jsonlite
@@ -2890,13 +2890,13 @@ variety of formats.")
 (define-public r-gtable
   (package
     (name "r-gtable")
-    (version "0.3.2")
+    (version "0.3.3")
     (source (origin
               (method url-fetch)
               (uri (cran-uri "gtable" version))
               (sha256
                (base32
-                "1j162vkyvkyyz61smw36crgmd76jic17n9qfmn0cyvafzdyqyiwd"))))
+                "0fkv19h64cyxsadplvyzbpjliy9wlfg56hc8znvqg972g3cmi6ig"))))
     (properties `((upstream-name . "gtable")))
     (build-system r-build-system)
     (propagated-inputs
@@ -3009,13 +3009,13 @@ engine (version 3.8.8.2) is included.")
 (define-public r-rcurl
   (package
     (name "r-rcurl")
-    (version "1.98-1.10")
+    (version "1.98-1.12")
     (source (origin
               (method url-fetch)
               (uri (cran-uri "RCurl" version))
               (sha256
                (base32
-                "1m7i0q9scrh2bfr0nqs029052kznhlv3siz9055pzdvgig7jnqjs"))))
+                "1ci6lsxm0f13yzw712gcbq23syl54x5llvhs2w1b8wwm9vqgx0qs"))))
     (properties `((upstream-name . "RCurl")))
     (build-system r-build-system)
     (arguments
@@ -3032,7 +3032,7 @@ if (certs != \"\") { .opts = merge.list(.opts, list(cainfo=certs)) }
     (native-inputs
      (list libxml2))
     (inputs
-     (list curl zlib))
+     (list curl))
     (propagated-inputs
      (list r-bitops))
     (home-page "https://www.omegahat.net/RCurl")
@@ -3172,14 +3172,14 @@ statements.")
 (define-public r-segmented
   (package
     (name "r-segmented")
-    (version "1.6-2")
+    (version "1.6-3")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "segmented" version))
        (sha256
         (base32
-         "0livckkhci3w1x9xai2m0a30fj06qsks2qds7y5jr9vwx03jqg21"))))
+         "0x7k5ycbvnfqsygrcyaaxnl0060x6869b345xc697hhr9sfxb4ai"))))
     (build-system r-build-system)
     (propagated-inputs (list r-mass r-nlme))
     (home-page "https://cran.r-project.org/web/packages/segmented")
@@ -3801,13 +3801,13 @@ analysis of large sparse or dense matrices.")
 (define-public r-glmnet
   (package
    (name "r-glmnet")
-   (version "4.1-6")
+   (version "4.1-7")
    (source
     (origin
      (method url-fetch)
      (uri (cran-uri "glmnet" version))
      (sha256
-      (base32 "0c3y9g3k0f0yclcffxzgfhfylb3py0iydhyspcjdrl44lb7cdi5y"))))
+      (base32 "1a7af2658z9fmx0rcdx401lj86q73qkvsvlfnrp2bw4xv43bd85k"))))
    (build-system r-build-system)
    (native-inputs
     (list gfortran r-knitr))
@@ -4307,14 +4307,14 @@ and tidyr provides no margins or aggregation.")
 (define-public r-hexbin
   (package
     (name "r-hexbin")
-    (version "1.28.2")
+    (version "1.28.3")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "hexbin" version))
        (sha256
         (base32
-         "0bbhs5pwxh474w62sq6gqvih7habancxng9wd4f2rgn6lv9zhhb2"))))
+         "0pyy97bh9xf9hijg3iw1z4ri01571r1fx7xqm3fjkzx4q48kbcqf"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-lattice))
@@ -5392,14 +5392,14 @@ can be efficiently implemented directly in the R language.")
 (define-public r-robustbase
   (package
     (name "r-robustbase")
-    (version "0.95-0")
+    (version "0.95-1")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "robustbase" version))
        (sha256
         (base32
-         "094pxwp78bmqyn6vncyzrazqxnn8abqsbzhlcq44avfz8qffmyjw"))))
+         "1sm37gqs35cvkacigsla8kzvpzjzsrgkabf58ymk9pzcndnx4b46"))))
     (build-system r-build-system)
     (native-inputs
      (list gfortran))
@@ -5840,13 +5840,13 @@ Companion to Applied Regression, Third Edition, Sage.")
 (define-public r-car
   (package
     (name "r-car")
-    (version "3.1-1")
+    (version "3.1-2")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "car" version))
        (sha256
-        (base32 "1g6jdcxl2aig6zirdn3k5l48sjmpljzy1aadnlr6mr6pxqamiicg"))))
+        (base32 "1j3l8r3j05769gdfrqz0n38xviq6pww1cjrgdd0fkj3sjy8k89l9"))))
     (build-system r-build-system)
     (propagated-inputs
      (list r-abind
@@ -5988,14 +5988,14 @@ multivariate case.")
 (define-public r-tclust
   (package
     (name "r-tclust")
-    (version "1.5-2")
+    (version "1.5-4")
     (source
      (origin
        (method url-fetch)
        (uri (cran-uri "tclust" version))
        (sha256
         (base32
-         "12vg9q35srddjidrn3q955xybn6ldraya35s4955ypj61arp89j9"))))
+         "1a3i6kvfzc2d6rdf75w03n5172jihhqa8mvzcb4m8l0w6mgdlm9b"))))
     (build-system r-build-system)
     ;; These are all suggested packages, not build dependencies.
     (propagated-inputs
@@ -7356,16 +7356,16 @@ Neyman, 1936; cf.  Spiller et al., 2012), etc.")
 (define-public r-mumin
   (package
     (name "r-mumin")
-    (version "1.47.1")
+    (version "1.47.5")
     (source (origin
               (method url-fetch)
               (uri (cran-uri "MuMIn" version))
               (sha256
                (base32
-                "1xhsc9hmx2b3zqyvpjs64rs90ccrfcsglrq2mhh85mgplsnva8qj"))))
+                "0xqasb79lmdhff25zalzrpjwv6qs9qnxr54ypnqjjgshi96mbwvg"))))
     (properties `((upstream-name . "MuMIn")))
     (build-system r-build-system)
-    (propagated-inputs (list r-matrix r-nlme))
+    (propagated-inputs (list r-insight r-matrix r-nlme))
     (home-page "https://cran.r-project.org/package=MuMIn")
     (synopsis "Multi-Model Inference")
     (description
diff --git a/gnu/packages/tex.scm b/gnu/packages/tex.scm
index 40accf642d..b40e72c582 100644
--- a/gnu/packages/tex.scm
+++ b/gnu/packages/tex.scm
@@ -6,7 +6,7 @@
 ;;; Copyright © 2016, 2018, 2019, 2020, 2021 Efraim Flashner <efraim@flashner.co.il>
 ;;; Copyright © 2016 Federico Beffa <beffa@fbengineering.ch>
 ;;; Copyright © 2016 Thomas Danckaert <post@thomasdanckaert.be>
-;;; Copyright © 2016, 2017, 2018, 2019, 2020, 2021, 2022 Ricardo Wurmus <rekado@elephly.net>
+;;; Copyright © 2016-2023 Ricardo Wurmus <rekado@elephly.net>
 ;;; Copyright © 2017 Leo Famulari <leo@famulari.name>
 ;;; Copyright © 2017, 2020, 2021 Marius Bakke <marius@gnu.org>
 ;;; Copyright © 2017, 2018, 2019, 2020 Tobias Geerinckx-Rice <me@tobias.gr>
@@ -24,6 +24,7 @@
 ;;; Copyright © 2022 Fabio Natali <me@fabionatali.com>
 ;;; Copyright © 2022 Philip McGrath <philip@philipmcgrath.com>
 ;;; Copyright © 2023 Thomas Albers Raviola <thomas@thomaslabs.org>
+;;; Copyright © 2023 John Kehayias <john.kehayias@protonmail.com>
 ;;;
 ;;; This file is part of GNU Guix.
 ;;;
@@ -740,6 +741,37 @@ the autogenerated files @file{language.dat} and @file{language.def} (and
 default versions of those), etc.")
     (license license:knuth)))
 
+(define-public texlive-dvipdfmx
+  (let ((template (simple-texlive-package
+                   "texlive-dvipdfmx"
+                   (list "doc/dvipdfm/"
+                         "doc/dvipdfmx/"
+                         "doc/man/man1/"
+                         "dvipdfmx/"
+                         "fonts/cmap/dvipdfmx/"
+                         "fonts/map/dvipdfmx/")
+                   (base32
+                    "04x93w777l9qzdzglwanb14k8cmq74kjcsgyanvp3bsmnn5zfrgz")
+                   #:trivial? #t)))
+    (package
+      (inherit template)
+      (source
+       (origin
+         (inherit (package-source template))
+         ;; This map file is supposed to be generated in a profile hook.
+         (snippet '(delete-file "fonts/map/dvipdfmx/updmap/kanjix.map"))))
+      (propagated-inputs (list texlive-glyphlist))
+      (home-page "https://www.tug.org/texlive/")
+      (synopsis "Extended version of dvipdfm")
+      (description
+       "Dvipdfmx (formerly dvipdfm-cjk) is a development of dvipdfm created to
+support multi-byte character encodings and large character sets for East Asian
+languages.  Dvipdfmx, if \"called\" with the name dvipdfm, operates in a
+\"dvipdfm compatibility\" mode, so that users of the both packages need only
+keep one executable.  A secondary design goal is to support as many \"PDF\"
+features as does pdfTeX.")
+      (license license:gpl3+))))
+
 (define-public texlive-dvips
   (package
     (inherit (simple-texlive-package
@@ -1623,6 +1655,60 @@ described in the TeXbook, together with various supporting files (some also
 discussed in the book).")
     (license license:knuth)))
 
+(define-public texlive-halloweenmath
+  (let ((template (simple-texlive-package
+                   "texlive-halloweenmath"
+                   (list "doc/latex/halloweenmath/"
+                         "source/latex/halloweenmath/"
+                         "tex/latex/halloweenmath/")
+                   (base32
+                    "1xq72k1p820b5q3haxf936g69p6gv34hr30870l96jnxa3ad7y05"))))
+    (package
+      (inherit template)
+      (outputs '("out" "doc"))
+      (arguments
+       (substitute-keyword-arguments (package-arguments template)
+         ((#:tex-directory _ #t) "latex/halloweenmath")
+         ((#:build-targets _ '()) '(list "halloweenmath.ins"))
+         ((#:phases phases)
+          #~(modify-phases #$phases
+              (add-after 'unpack 'chdir
+                (lambda _ (chdir "source/latex/halloweenmath/")))
+              (add-after 'chdir 'non-interactive-build
+                ;; When it realizes it cannot employ the usedir directive, the
+                ;; build process stops and waits for an input before inserting
+                ;; generated files in the working directory.  Do not ask for
+                ;; an input.
+                (lambda _
+                  (substitute* "halloweenmath.ins"
+                    (("\\Ask.*") "")
+                    (("\\(your .*? will be ignored\\).*") ""))))
+              (replace 'copy-files
+                (lambda* (#:key inputs #:allow-other-keys)
+                  (let ((origin (assoc-ref inputs "source"))
+                        (source (string-append #$output
+                                               "/share/texmf-dist/source"))
+                        (doc (string-append #$output:doc
+                                            "/share/texmf-dist/doc")))
+                    (copy-recursively (string-append origin "/source") source)
+                    (copy-recursively (string-append origin "/doc") doc))))))))
+      (native-inputs
+       (list texlive-bin
+             texlive-kpathsea
+             (texlive-updmap.cfg)))     ;for psfonts.map
+      (propagated-inputs
+       (list texlive-amsmath texlive-pict2e))
+      (home-page "https://ctan.org/pkg/halloweenmath")
+      (synopsis "Scary and creepy math symbols with AMS-LaTeX integration")
+      (description
+       "The package defines a handful of commands for typesetting mathematical
+symbols of various kinds, ranging from large operators to extensible
+arrow-like relations and growing arrow-like math accents that all draw from
+the classic Halloween-related iconography (pumpkins, witches, ghosts, cats,
+and so on) while being, at the same time, seamlessly integrated within the
+rest of the mathematics produced by (AmS-)LaTeX.")
+      (license license:lppl1.3+))))
+
 (define-public texlive-hardwrap
   (package
     (inherit (simple-texlive-package
@@ -3212,6 +3298,22 @@ verbatim mode; build \"example\" environments (showing both result and
 verbatim source).")
     (license license:lppl1.0+)))
 
+(define-public texlive-glyphlist
+  (package
+    (inherit (simple-texlive-package
+              "texlive-glyphlist"
+              (list "fonts/map/glyphlist/")
+              (base32
+               "12nmmyh77vr2622lzi11nm1z1k2bxs7jz018yl4rwjlpg0sxg1ja")
+              #:trivial? #t))
+    (home-page "https://www.tug.org/texlive/")
+    (synopsis "Adobe glyph list and TeX extensions")
+    (description
+     "This package provides a map between traditional Adobe glyph names and
+Unicode points; it is maintained by Adobe.  The additional
+@file{texglyphlist.txt} is maintained as part of lcdf-typetools.")
+    (license license:asl2.0)))
+
 (define-public texlive-graphics-def
   (package
     (inherit (simple-texlive-package
@@ -4391,6 +4493,55 @@ T2* and X2 encodings. These encodings cover (between them) pretty much every
 language that is written in a Cyrillic alphabet.")
     (license license:lppl1.3c+)))
 
+(define-public texlive-pict2e
+  (let ((template (simple-texlive-package
+                   "texlive-pict2e"
+                   (list "doc/latex/pict2e/"
+                         "source/latex/pict2e/"
+                         "tex/latex/pict2e/")
+                   (base32
+                    "0pazv1khsgjhxc673qrhjrbzlkgmcj53qccb9hw7ygdajxrjc2ba"))))
+    (package
+      (inherit template)
+      (arguments
+       (substitute-keyword-arguments (package-arguments template)
+         ((#:tex-directory _ #t) "latex/pict2e")
+         ((#:build-targets _ '()) '(list "pict2e.ins"))
+         ((#:phases phases)
+          #~(modify-phases #$phases
+              (add-after 'unpack 'chdir
+                (lambda _ (chdir "source/latex/pict2e/")))
+              (add-after 'build 'build-doc
+                (lambda _
+                  (copy-file "p2e-drivers.dtx" "build/p2e-drivers.dtx")
+                  (with-directory-excursion "build"
+                    (invoke "pdflatex" "p2e-drivers.dtx")
+                    (delete-file "p2e-drivers.dtx")
+                    ;; texlive.tlpbd expects a "pict2e.cfg" configuration file
+                    ;; instead of "pict2e-example.cfg".  Please it.
+                    (rename-file "pict2e-example.cfg" "pict2e.cfg"))))
+              (replace 'copy-files
+                (lambda* (#:key inputs #:allow-other-keys)
+                  (let ((origin (assoc-ref inputs "source"))
+                        (source (string-append #$output
+                                               "/share/texmf-dist/source"))
+                        (doc (string-append #$output:doc
+                                            "/share/texmf-dist/doc")))
+                    (copy-recursively (string-append origin "/source") source)
+                    (copy-recursively (string-append origin "/doc") doc))))))))
+      (home-page "https://ctan.org/pkg/pict2e")
+      (native-inputs
+       (list (texlive-updmap.cfg)))
+      (synopsis "New implementation of picture commands")
+      (description
+       "This package extends the existing LaTeX @code{picture} environment,
+using the familiar technique (the @code{graphics} and @code{color} packages)
+of driver files (at present, drivers for dvips, pdfTeX, LuaTeX, XeTeX, VTeX,
+dvipdfm, and dvipdfmx are available).  The package documentation has a fair
+number of examples of use, showing where things are improved by comparison
+with the LaTeX @code{picture} environment.")
+      (license license:lppl1.3+))))
+
 (define-public texlive-psnfss
   (let ((template (simple-texlive-package
                    "texlive-psnfss"
@@ -5016,6 +5167,44 @@ corresponding italics: light, regular, medium, bold, ...")
     (license (list license:lppl
                    license:silofl1.1))))
 
+(define-public texlive-firstaid
+  (let ((template (simple-texlive-package
+                   "texlive-firstaid"
+                   (list "/doc/latex/firstaid/"
+                         "/source/latex/firstaid/"
+                         "/tex/latex/firstaid/")
+                   (base32
+                    "1ahn47kz8a2qdmzdfdgjanf6h5bn8f2rzp1zvwgjpk1plcix8k90"))))
+    (package
+      (inherit template)
+      (arguments
+       (substitute-keyword-arguments (package-arguments template)
+         ((#:tex-directory _ #t) "tex/latex/firstaid")
+         ((#:build-targets _ '()) '(list "firstaid.ins"))
+         ((#:phases phases)
+          #~(modify-phases #$phases
+              (add-after 'unpack 'chdir
+                (lambda _ (chdir "source/latex/firstaid/")))
+              (replace 'copy-files
+                (lambda* (#:key inputs #:allow-other-keys)
+                  (let ((origin (assoc-ref inputs "source"))
+                        (source (string-append #$output
+                                               "/share/texmf-dist/source"))
+                        (doc (string-append #$output:doc
+                                            "/share/texmf-dist/doc")))
+                    (copy-recursively (string-append origin "/source") source)
+                    (copy-recursively (string-append origin "/doc") doc))))))))
+      (home-page "https://ctan.org/macros/latex/required/firstaid")
+      (synopsis
+       "First aid for external LaTeX files and packages that need updating")
+      (description
+       "This package contains some first aid for LaTeX packages or classes
+that require updates because of internal changes to the LaTeX kernel that are
+not yet reflected in the package's or class's code.  The file
+@file{latex2e-first-aid-for-external-files.ltx} provided by this package is
+meant to be loaded during format generation and not by the user.")
+      (license license:lppl1.3c))))
+
 (define-public texlive-latex-ifplatform
   (package
     (name "texlive-latex-ifplatform")
@@ -11269,6 +11458,24 @@ family and SGML-based languages.  Xindy is highly configurable, both in markup
 terms and in terms of the collating order of the text being processed.")
     (license license:gpl2+)))
 
+(define-public texlive-nth
+  (package
+    (inherit (simple-texlive-package
+              "texlive-nth"
+              (list "tex/generic/nth/")
+              (base32
+               "0716sd99xjdkplm7jdmg4lx8lpfnnx6mxjp1l1sp2bfqcg73p4hm")
+              #:trivial? #t))
+    (home-page "https://ctan.org/macros/generic/misc/nth.sty")
+    (synopsis "Generate English ordinal numbers")
+    (description
+     "The command @code{\\nth{<number>}} generates English ordinal numbers of
+the form 1st, 2nd, 3rd, 4th, etc.  LaTeX package options may specify that the
+ordinal mark be superscripted, and that negative numbers may be treated; Plain
+TeX users have no access to package options, so need to redefine macros for
+these changes.")
+    (license license:public-domain)))
+
 (define-public texlive-fmtcount
   (package
     (inherit (simple-texlive-package
@@ -12307,6 +12514,50 @@ interest.  Since most such counters are simply incremented when they are
 changed, the recorded value will usually be the maximum value.")
     (license license:lppl1.3c+)))
 
+(define-public texlive-xetex
+  (package
+    (inherit (simple-texlive-package
+              "texlive-xetex"
+              (list "/doc/man/man1/xetex.1"
+                    "/doc/man/man1/xelatex.1"
+                    "/doc/xetex/base/"
+                    "/fonts/misc/xetex/fontmapping/base/"
+                    "/tex/xelatex/xetexconfig/")
+              (base32
+               "1gmgagvsv2qknrjzjk840ca3wging8wfc20rgq7bnhphm9n87m6q")
+              #:trivial? #t))
+    (propagated-inputs
+     (list texlive-generic-atbegshi
+           texlive-latex-atveryend
+           texlive-babel
+           texlive-cm
+           texlive-dvipdfmx
+           texlive-etex
+           texlive-everyshi
+           texlive-firstaid
+           texlive-hyphen-base
+           texlive-latex-base
+           texlive-fonts-latex
+           texlive-latex-l3backend
+           texlive-latex-l3kernel
+           texlive-latex-l3packages
+           texlive-lm
+           texlive-tex-ini-files
+           texlive-tex-plain
+           texlive-unicode-data))
+    (home-page "https://www.tug.org/texlive/")
+    (synopsis "Extended variant of TeX for use with Unicode sources")
+    (description
+     "XeTeX is a TeX typesetting engine using Unicode and supporting modern font
+technologies such as OpenType, TrueType or Apple Advanced Typography (AAT),
+including OpenType mathematics fonts.  XeTeX supports many extensions that
+reflect its origins in linguistic research; it also supports micro-typography
+(as available in pdfTeX).  XeTeX was developed by the SIL (the first version
+was specifically developed for those studying linguistics, and using Macintosh
+computers).  XeTeX's immediate output is an extended variant of DVI format,
+which is ordinarily processed by a tightly bound processor (called
+@code{xdvipdfmx}), that produces PDF.")
+    (license license:x11)))
 ;;;
 ;;; Avoid adding new packages to the end of this file. To reduce the chances
 ;;; of a merge conflict, place them above by existing packages with similar
diff --git a/gnu/packages/tree-sitter.scm b/gnu/packages/tree-sitter.scm
index 8dda7737ca..b91345bb36 100644
--- a/gnu/packages/tree-sitter.scm
+++ b/gnu/packages/tree-sitter.scm
@@ -301,6 +301,13 @@ will be used in description and synopsis."
        #:commit commit
        #:license (list license:asl2.0 license:expat))))
 
+(define-public tree-sitter-heex
+  (tree-sitter-grammar
+   "heex" "Heex"
+   "00330rgg67fq0d9gk1yswj78d9mn1jvvjmmy1k7cxpvm5993p3sw"
+   "0.6.0"
+   #:repository-url "https://github.com/phoenixframework/tree-sitter-heex"))
+
 (define-public tree-sitter-bash
   (tree-sitter-grammar
    "bash" "Bash"
diff --git a/gnu/packages/wm.scm b/gnu/packages/wm.scm
index bcc68fbad2..4e52554b87 100644
--- a/gnu/packages/wm.scm
+++ b/gnu/packages/wm.scm
@@ -1061,6 +1061,28 @@ experience.")
     (home-page "http://fluxbox.org/")
     (license license:expat)))
 
+(define-public fbautostart
+  (package
+    (name "fbautostart")
+    (version "2.718281828")
+    (source (origin
+              (method git-fetch)
+              (uri (git-reference
+                     (url "https://github.com/paultag/fbautostart.git")
+                     (commit version)))
+              (file-name (string-append name "-" version "-checkout"))
+              (sha256
+               (base32
+                "13h6j5khi5axqhflzhayzgvyhxylmk5vsgin235ji440mzd516gz"))))
+    (build-system gnu-build-system)
+    (native-inputs
+     (list autoconf automake))
+    (synopsis "XDG autostarter for Fluxbox window manager")
+    (description "This package provides an autostarter complaint with
+the XDG Autostart specification.")
+    (home-page "https://github.com/paultag/fbautostart")
+    (license license:expat)))
+
 (define-public fnott
   (package
     (name "fnott")
diff --git a/gnu/services/base.scm b/gnu/services/base.scm
index 5b0b3bb0ab..e063828d3b 100644
--- a/gnu/services/base.scm
+++ b/gnu/services/base.scm
@@ -40,7 +40,7 @@
 (define-module (gnu services base)
   #:use-module (guix store)
   #:use-module (guix deprecation)
-  #:autoload   (guix diagnostics) (warning &fix-hint)
+  #:autoload   (guix diagnostics) (warning formatted-message &fix-hint)
   #:autoload   (guix i18n) (G_)
   #:use-module (guix combinators)
   #:use-module (gnu services)
@@ -246,7 +246,7 @@
             kmscon-service-type
 
             pam-limits-service-type
-            pam-limits-service
+            pam-limits-service  ; deprecated
 
             greetd-service-type
             greetd-configuration
@@ -1588,17 +1588,13 @@ information on the configuration file syntax."
 
 
 (define pam-limits-service-type
-  (let ((security-limits
-         ;; Create /etc/security containing the provided "limits.conf" file.
-         (lambda (limits-file)
-           `(("security/limits.conf"
-              ,limits-file))))
-        (pam-extension
+  (let ((pam-extension
          (lambda (pam)
            (let ((pam-limits (pam-entry
                               (control "required")
                               (module "pam_limits.so")
-                              (arguments '("conf=/etc/security/limits.conf")))))
+                              (arguments
+                               '("conf=/etc/security/limits.conf")))))
              (if (member (pam-service-name pam)
                          '("login" "greetd" "su" "slim" "gdm-password" "sddm"
                            "sudo" "sshd"))
@@ -1606,7 +1602,27 @@ information on the configuration file syntax."
                   (inherit pam)
                   (session (cons pam-limits
                                  (pam-service-session pam))))
-                 pam)))))
+                 pam))))
+
+        ;; XXX: Using file-like objects is deprecated, use lists instead.
+        ;;      This is to be reduced into the list? case when the deprecated
+        ;;      code gets removed.
+        ;; Create /etc/security containing the provided "limits.conf" file.
+        (security-limits
+         (match-lambda
+           ((? file-like? obj)
+            (warning (G_ "Using file-like value for \
+'pam-limits-service-type' is deprecated~%"))
+            `(("security/limits.conf" ,obj)))
+           ((? list? lst)
+            `(("security/limits.conf"
+               ,(plain-file "limits.conf"
+                            (string-join (map pam-limits-entry->string lst)
+                                         "\n" 'suffix)))))
+           (_ (raise
+               (formatted-message
+                (G_ "invalid input for 'pam-limits-service-type'~%")))))))
+
     (service-type
      (name 'limits)
      (extensions
@@ -1616,9 +1632,11 @@ information on the configuration file syntax."
      (description
       "Install the specified resource usage limits by populating
 @file{/etc/security/limits.conf} and using the @code{pam_limits}
-authentication module."))))
+authentication module.")
+     (default-value '()))))
 
-(define* (pam-limits-service #:optional (limits '()))
+(define-deprecated (pam-limits-service #:optional (limits '()))
+  pam-limits-service-type
   "Return a service that makes selected programs respect the list of
 pam-limits-entry specified in LIMITS via pam_limits.so."
   (service pam-limits-service-type
diff --git a/gnu/services/configuration.scm b/gnu/services/configuration.scm
index 174c2f20d2..ed9d95f906 100644
--- a/gnu/services/configuration.scm
+++ b/gnu/services/configuration.scm
@@ -264,7 +264,6 @@ does not have a default value" field kind)))
                       (serializer field-serializer)
                       (default-value-thunk
                         (lambda ()
-                          (display '#,(id #'stem #'% #'stem))
                           (if (maybe-value-set? (syntax->datum field-default))
                               field-default
                               (configuration-missing-default-value
diff --git a/gnu/system.scm b/gnu/system.scm
index 48cc68f449..c17c6e4e98 100644
--- a/gnu/system.scm
+++ b/gnu/system.scm
@@ -1201,15 +1201,7 @@ use 'plain-file' instead~%")
 
     ;; By default, applications that use D-Bus, such as Emacs, abort at startup
     ;; when /etc/machine-id is missing.  Make sure these warnings are non-fatal.
-    ("DBUS_FATAL_WARNINGS" . "0")
-
-    ;; XXX: Normally we wouldn't need to do this, but our glibc@2.23 package
-    ;; used to look things up in 'PREFIX/lib/locale' instead of
-    ;; '/run/current-system/locale' as was intended.  Keep this hack around so
-    ;; that people who still have glibc@2.23-using packages in their profiles
-    ;; can use them correctly.
-    ;; TODO: Remove when glibc@2.23 is long gone.
-    ("GUIX_LOCPATH" . "/run/current-system/locale")))
+    ("DBUS_FATAL_WARNINGS" . "0")))
 
 ;; Ensure LST is a list of <setuid-program> records and warn otherwise.
 (define-with-syntax-properties (ensure-setuid-program-list (lst properties))
diff --git a/gnu/tests/pam.scm b/gnu/tests/pam.scm
new file mode 100644
index 0000000000..5cf13d97d7
--- /dev/null
+++ b/gnu/tests/pam.scm
@@ -0,0 +1,97 @@
+;;; GNU Guix --- Functional package management for GNU
+;;; Copyright © 2023 Bruno Victal <mirai@makinata.eu>
+;;;
+;;; This file is part of GNU Guix.
+;;;
+;;; GNU Guix is free software; you can redistribute it and/or modify it
+;;; under the terms of the GNU General Public License as published by
+;;; the Free Software Foundation; either version 3 of the License, or (at
+;;; your option) any later version.
+;;;
+;;; GNU Guix is distributed in the hope that it will be useful, but
+;;; WITHOUT ANY WARRANTY; without even the implied warranty of
+;;; MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+;;; GNU General Public License for more details.
+;;;
+;;; You should have received a copy of the GNU General Public License
+;;; along with GNU Guix.  If not, see <http://www.gnu.org/licenses/>.
+
+(define-module (gnu tests pam)
+  #:use-module (gnu tests)
+  #:use-module (gnu services)
+  #:use-module (gnu services base)
+  #:use-module (gnu system)
+  #:use-module (gnu system pam)
+  #:use-module (gnu system vm)
+  #:use-module (guix gexp)
+  #:use-module (ice-9 format)
+  #:export (%test-pam-limits
+            %test-pam-limits-deprecated))
+
+
+;;;
+;;; pam-limits-service-type
+;;;
+
+(define pam-limit-entries
+  (list
+   (pam-limits-entry "@realtime" 'both 'rtprio 99)
+   (pam-limits-entry "@realtime" 'both 'memlock 'unlimited)))
+
+(define (run-test-pam-limits config)
+  "Run tests in a os with pam-limits-service-type configured."
+  (define os
+    (marionette-operating-system
+     (simple-operating-system
+      (service pam-limits-service-type config))))
+
+  (define vm
+    (virtual-machine os))
+
+  (define name (format #f "pam-limit-service~:[~;-deprecated~]"
+                       (file-like? config)))
+
+  (define test
+    (with-imported-modules '((gnu build marionette))
+      #~(begin
+          (use-modules (gnu build marionette)
+                       (srfi srfi-64))
+
+          (let ((marionette (make-marionette (list #$vm))))
+
+            (test-runner-current (system-test-runner #$output))
+
+            (test-begin #$name)
+
+            (test-assert "/etc/security/limits.conf ready"
+              (wait-for-file "/etc/security/limits.conf" marionette))
+
+            (test-equal "/etc/security/limits.conf content matches"
+              #$(string-join (map pam-limits-entry->string pam-limit-entries)
+                             "\n" 'suffix)
+              (marionette-eval
+               '(call-with-input-file "/etc/security/limits.conf"
+                  get-string-all)
+               marionette))
+
+            (test-end)))))
+
+  (gexp->derivation (string-append name "-test") test))
+
+(define %test-pam-limits
+  (system-test
+   (name "pam-limits-service")
+   (description "Test that pam-limits-service can serialize its config
+(as a list) to @file{limits.conf}.")
+   (value (run-test-pam-limits pam-limit-entries))))
+
+(define %test-pam-limits-deprecated
+  (system-test
+   (name "pam-limits-service-deprecated")
+   (description "Test that pam-limits-service can serialize its config
+(as a file-like object) to @file{limits.conf}.")
+   (value (run-test-pam-limits
+           (plain-file "limits.conf"
+                       (string-join (map pam-limits-entry->string
+                                         pam-limit-entries)
+                                    "\n" 'suffix))))))
diff --git a/guix/import/texlive.scm b/guix/import/texlive.scm
index 82014ee568..086cd363a9 100644
--- a/guix/import/texlive.scm
+++ b/guix/import/texlive.scm
@@ -1,5 +1,5 @@
 ;;; GNU Guix --- Functional package management for GNU
-;;; Copyright © 2017, 2021, 2022 Ricardo Wurmus <rekado@elephly.net>
+;;; Copyright © 2017, 2021, 2022, 2023 Ricardo Wurmus <rekado@elephly.net>
 ;;; Copyright © 2021 Maxim Cournoyer <maxim.cournoyer@gmail.com>
 ;;;
 ;;; This file is part of GNU Guix.
@@ -246,11 +246,15 @@ of those files are returned that are unexpectedly installed."
 (define (tlpdb->package name version package-database)
   (and-let* ((data (assoc-ref package-database name))
              (dirs (files->directories
-                    (map (lambda (dir)
-                           (string-drop dir (string-length "texmf-dist/")))
-                         (append (or (assoc-ref data 'docfiles) (list))
-                                 (or (assoc-ref data 'runfiles) (list))
-                                 (or (assoc-ref data 'srcfiles) (list))))))
+                    (filter-map (lambda (dir)
+                                  ;; Ignore any file not starting with the
+                                  ;; expected prefix.  Nothing good can come
+                                  ;; from this.
+                                  (and (string-prefix? "texmf-dist/" dir)
+                                       (string-drop dir (string-length "texmf-dist/"))))
+                                (append (or (assoc-ref data 'docfiles) (list))
+                                        (or (assoc-ref data 'runfiles) (list))
+                                        (or (assoc-ref data 'srcfiles) (list))))))
              (name (guix-name name))
              ;; TODO: we're ignoring the VERSION argument because that
              ;; information is distributed across %texlive-tag and
@@ -260,6 +264,12 @@ of those files are returned that are unexpectedly installed."
                                        %texlive-tag "/Master/texmf-dist"))
                    (locations dirs)
                    (revision %texlive-revision)))
+             ;; Ignore arch-dependent packages.
+             (filtered-depends
+              (or (and=> (assoc-ref data 'depend)
+                         (lambda (inputs)
+                           (remove (cut string-suffix? ".ARCH" <>) inputs)))
+                  '()))
              (source (with-store store
                        (download-multi-svn-to-store
                         store ref (string-append name "-svn-multi-checkout")))))
@@ -278,24 +288,25 @@ of those files are returned that are unexpectedly installed."
         ;; package->definition in (guix import utils) expects to see a
         ;; version field.
         (version ,version)
-        ,@(or (and=> (assoc-ref data 'depend)
-                     (lambda (inputs)
-                       `((propagated-inputs
-                          (list ,@(map (lambda (tex-name)
-                                         (let ((name (guix-name tex-name)))
-                                           (string->symbol name)))
-                                       inputs))))))
-              '())
-        ,@(or (and=> (assoc-ref data 'catalogue-ctan)
-                     (lambda (url)
-                       `((home-page ,(string-append "https://ctan.org" url)))))
+        ,@(match filtered-depends
+            (() '())
+            (inputs
+             `((propagated-inputs
+                (list ,@(map
+                         (lambda (tex-name)
+                           (let ((name (guix-name tex-name)))
+                             (string->symbol name)))
+                         inputs))))))
+        ,@(or (and=> (assoc-ref data 'name)
+                     (lambda (name)
+                       `((home-page ,(string-append "https://ctan.org/pkg/"
+                                                    name)))))
               '((home-page "https://www.tug.org/texlive/")))
         (synopsis ,(assoc-ref data 'shortdesc))
-        (description ,(beautify-description
-                       (assoc-ref data 'longdesc)))
-        (license ,(string->license
-                   (assoc-ref data 'catalogue-license))))
-     (or (assoc-ref data 'depend) (list)))))
+        (description ,(and=> (assoc-ref data 'longdesc) beautify-description))
+        (license ,(and=> (assoc-ref data 'catalogue-license)
+                         string->license)))
+     filtered-depends)))
 
 (define texlive->guix-package
   (memoize