diff options
Diffstat (limited to 'gnu/packages/bioinformatics.scm')
| -rw-r--r-- | gnu/packages/bioinformatics.scm | 110 |
1 files changed, 94 insertions, 16 deletions
diff --git a/gnu/packages/bioinformatics.scm b/gnu/packages/bioinformatics.scm index c7836f173e..7175ecf41d 100644 --- a/gnu/packages/bioinformatics.scm +++ b/gnu/packages/bioinformatics.scm @@ -34,6 +34,7 @@ #:use-module (gnu packages file) #:use-module (gnu packages java) #:use-module (gnu packages linux) + #:use-module (gnu packages machine-learning) #:use-module (gnu packages maths) #:use-module (gnu packages ncurses) #:use-module (gnu packages perl) @@ -438,6 +439,76 @@ multiple sequence alignments.") "CLIPper is a tool to define peaks in CLIP-seq datasets.") (license license:gpl2))) +(define-public couger + (package + (name "couger") + (version "1.8.2") + (source (origin + (method url-fetch) + (uri (string-append + "http://couger.oit.duke.edu/static/assets/COUGER" + version ".zip")) + (sha256 + (base32 + "04p2b14nmhzxw5h72mpzdhalv21bx4w9b87z0wpw0xzxpysyncmq")))) + (build-system gnu-build-system) + (arguments + `(#:tests? #f + #:phases + (modify-phases %standard-phases + (delete 'configure) + (delete 'build) + (replace + 'install + (lambda* (#:key outputs #:allow-other-keys) + (let ((out (assoc-ref outputs "out"))) + (copy-recursively "src" (string-append out "/src")) + (mkdir (string-append out "/bin")) + ;; Add "src" directory to module lookup path. + (substitute* "couger" + (("from argparse") + (string-append "import sys\nsys.path.append(\"" + out "\")\nfrom argparse"))) + (copy-file "couger" (string-append out "/bin/couger"))) + #t)) + (add-after + 'install 'wrap-program + (lambda* (#:key inputs outputs #:allow-other-keys) + ;; Make sure 'couger' runs with the correct PYTHONPATH. + (let* ((out (assoc-ref outputs "out")) + (path (getenv "PYTHONPATH"))) + (wrap-program (string-append out "/bin/couger") + `("PYTHONPATH" ":" prefix (,path)))) + #t))))) + (inputs + `(("python" ,python-2) + ("python2-pillow" ,python2-pillow) + ("python2-numpy" ,python2-numpy) + ("python2-scipy" ,python2-scipy) + ("python2-matplotlib" ,python2-matplotlib))) + (propagated-inputs + `(("r" ,r) + ("libsvm" ,libsvm) + ("randomjungle" ,randomjungle))) + (native-inputs + `(("unzip" ,unzip))) + (home-page "http://couger.oit.duke.edu") + (synopsis "Identify co-factors in sets of genomic regions") + (description + "COUGER can be applied to any two sets of genomic regions bound by +paralogous TFs (e.g., regions derived from ChIP-seq experiments) to identify +putative co-factors that provide specificity to each TF. The framework +determines the genomic targets uniquely-bound by each TF, and identifies a +small set of co-factors that best explain the in vivo binding differences +between the two TFs. + +COUGER uses classification algorithms (support vector machines and random +forests) with features that reflect the DNA binding specificities of putative +co-factors. The features are generated either from high-throughput TF-DNA +binding data (from protein binding microarray experiments), or from large +collections of DNA motifs.") + (license license:gpl3+))) + (define-public clustal-omega (package (name "clustal-omega") @@ -1030,6 +1101,27 @@ RNA-Seq, the MISO model uses Bayesian inference to compute the probability that a read originated from a particular isoform.") (license license:gpl2))) +(define-public orfm + (package + (name "orfm") + (version "0.3.2") + (source (origin + (method url-fetch) + (uri (string-append + "https://github.com/wwood/OrfM/releases/download/v" + version "/orfm-" version ".tar.gz")) + (sha256 + (base32 + "00jqvlspj9662ni9r4n1snxfnwkzc02i46g5nk1kwjshi6v3vgg3")))) + (build-system gnu-build-system) + (inputs `(("zlib" ,zlib))) + (synopsis "Simple and not slow open reading frame (ORF) caller") + (description + "An ORF caller finds stretches of DNA that when translated are not +interrupted by stop codons. OrfM finds and prints these ORFs.") + (home-page "https://github.com/wwood/OrfM") + (license license:lgpl3+))) + (define-public python2-pbcore (package (name "python2-pbcore") @@ -1331,7 +1423,7 @@ viewer.") (define-public ngs-sdk (package (name "ngs-sdk") - (version "1.1.0") + (version "1.1.1") (source (origin (method url-fetch) @@ -1341,7 +1433,7 @@ viewer.") (file-name (string-append name "-" version ".tar.gz")) (sha256 (base32 - "09fakv9w87lfg9g70kwzmnryqdjj1sz2c7kw01i6drjf787gkjhw")))) + "1x58gpm574n0xmk2a98gmikbgycq78ia0bvnb42k5ck34fmd5v8y")))) (build-system gnu-build-system) (arguments `(#:parallel-build? #f ; not supported @@ -1351,20 +1443,6 @@ viewer.") 'configure (lambda* (#:key outputs #:allow-other-keys) (let ((out (assoc-ref outputs "out"))) - ;; Only replace the version suffix, not the version number in the - ;; directory name; fixed in commit 46d4509fa8 (no release yet). - (substitute* "setup/konfigure.perl" - (((string-append "\\$\\(subst " - "(\\$\\(VERSION[^\\)]*\\))," - "(\\$\\([^\\)]+\\))," - "(\\$\\([^\\)]+\\)|\\$\\@)" - "\\)") - _ pattern replacement target) - (string-append "$(patsubst " - "%" pattern "," - "%" replacement "," - target ")"))) - ;; The 'configure' script doesn't recognize things like ;; '--enable-fast-install'. (zero? (system* "./configure" |