diff --git a/gnu/packages/patches/python-pyvex-remove-angr-dependency.patch b/gnu/packages/patches/python-pyvex-remove-angr-dependency.patch
new file mode 100644
index 0000000000..dccf22bbc6
--- /dev/null
+++ b/gnu/packages/patches/python-pyvex-remove-angr-dependency.patch
@@ -0,0 +1,80 @@
+This patch removes the angr dependency from the pyvex these, thus
+resolving a circular dependency (as angr depends on pyvex). This
+patch has been taken from upstream.
+
+This patch is a squashed version of the following upstream patches:
+
+* https://github.com/angr/pyvex/commit/61fb26f223a8d8a276b702d2448a12e02c5c9c6b
+* https://github.com/angr/pyvex/commit/a1fb2a4d0826b0e43bd8bbdd00b6db032643ec95
+
+diff --git a/tests/test_spotter.py b/tests/test_spotter.py
+index 9271ccd..bed7dd4 100644
+--- a/tests/test_spotter.py
++++ b/tests/test_spotter.py
+@@ -1,6 +1,5 @@
+ import os
+ 
+-import angr
+ import archinfo
+ 
+ import pyvex
+@@ -98,53 +97,28 @@ class CortexSpotter(GymratLifter):
+ register(CortexSpotter, "ARMEL")
+ 
+ 
+-def test_full_binary():
+-    p = angr.Project(
+-        os.path.join(test_location, "armel", "RTOSDemo.axf.issue_685"),
+-        arch="ARMEL",
+-        auto_load_libs=False,
+-    )
+-    st = p.factory.call_state(0x000013CE + 1)
+-    b = st.block().vex
+-    simgr = p.factory.simulation_manager(st)
+-    simgr.step()
+-    assert b.jumpkind == "Ijk_Sys_syscall"
+-    assert simgr.active[0].regs.ip_at_syscall.args[0] == 0x13FB
+-
+-
+ def test_tmrs():
+-    test_location = str(os.path.join(os.path.dirname(os.path.realpath(__file__)), "../../binaries/tests"))
+-    p = angr.Project(
+-        os.path.join(test_location, "armel", "helloworld"),
+-        arch="ARMEL",
+-        auto_load_libs=False,
+-    )
++    arch = archinfo.arch_from_id("ARMEL")
+     ins = b"\xef\xf3\x08\x82"
+-    b = pyvex.block.IRSB(ins, 1, p.arch)
++    b = pyvex.block.IRSB(ins, 1, arch)
+     assert b.jumpkind == "Ijk_Boring"
+     assert type(b.statements[1].data) == pyvex.expr.Get
+-    assert p.arch.register_names.get(b.statements[1].data.offset, "") == "sp"
++    assert arch.register_names.get(b.statements[1].data.offset, "") == "sp"
+     assert type(b.statements[2]) == pyvex.stmt.Put
+ 
+ 
+ def test_tmsr():
+-    test_location = str(os.path.join(os.path.dirname(os.path.realpath(__file__)), "../../binaries/tests"))
+-    p = angr.Project(
+-        os.path.join(test_location, "armel", "helloworld"),
+-        arch="ARMEL",
+-        auto_load_libs=False,
+-    )
++    arch = archinfo.arch_from_id("ARMEL")
+     inss = b"\x82\xf3\x08\x88"
+-    b = pyvex.block.IRSB(inss, 1, p.arch, opt_level=3)
++    b = pyvex.block.IRSB(inss, 1, arch, opt_level=3)
+     assert b.jumpkind == "Ijk_Boring"
+     assert type(b.statements[1].data) == pyvex.expr.Get
+-    assert p.arch.register_names.get(b.statements[1].data.offset, "") == "r2"
++    assert arch.register_names.get(b.statements[1].data.offset, "") == "r2"
+     assert type(b.statements[2]) == pyvex.stmt.Put
+ 
+ 
+ if __name__ == "__main__":
+     test_basic()
+     test_embedded()
+-    test_full_binary()
+     test_tmrs()
+     test_tmsr()