diff --git a/gnu/packages/python-crypto.scm b/gnu/packages/python-crypto.scm
index 6c25e0dd36..00e704a15f 100644
--- a/gnu/packages/python-crypto.scm
+++ b/gnu/packages/python-crypto.scm
@@ -585,14 +585,14 @@ message digests and key derivation functions.")
 (define-public python-pyopenssl
   (package
     (name "python-pyopenssl")
-    (version "20.0.0")
+    (version "20.0.1")
     (source
      (origin
        (method url-fetch)
        (uri (pypi-uri "pyOpenSSL" version))
        (sha256
         (base32
-         "1i8ab5zn9i9iq2ksizp3rd42v157kacddzz88kviqw3kpp68xw4j"))))
+         "0labcbh2g0jhgisd79wx9kixmi6fip28096d1xb05fj3jmsiq8sc"))))
     (build-system python-build-system)
     (arguments
      '(#:phases
@@ -604,7 +604,7 @@ message digests and key derivation functions.")
              ;; PyOpenSSL runs tests against a certificate with a fixed
              ;; expiry time.  To ensure successful builds in the future,
              ;; set the time to roughly the release date.
-             (invoke "faketime" "2020-12-01" "py.test" "-v" "-k"
+             (invoke "faketime" "2021-05-01" "py.test" "-v" "-k"
                      (string-append
                       ;; This test tries to look up certificates from
                       ;; the compiled-in default path in OpenSSL, which
@@ -804,31 +804,20 @@ PKCS#8, PKCS#12, PKCS#5, X.509 and TSP.")
            (substitute* "setup.py"
              (("\"wheel\"") ""))
            ;; Remove bundled libsodium.
-           (delete-file-recursively "src/libsodium")
-           #t))
+           (delete-file-recursively "src/libsodium")))
        (sha256
         (base32
          "01b56hxrbif3hx8l6rwz5kljrgvlbj7shmmd2rjh0hn7974a5sal"))))
     (build-system python-build-system)
     (arguments
-     `(#:modules (,@%python-build-system-modules
-                  (guix build utils)
-                  (ice-9 ftw)
-                  (srfi srfi-26))
-       #:phases
-       (modify-phases (@ (guix build python-build-system) %standard-phases)
+     `(#:phases
+       (modify-phases %standard-phases
          (add-before 'build 'use-system-sodium
            (lambda _
-             (setenv "SODIUM_INSTALL" "system")
-             #t))
+             (setenv "SODIUM_INSTALL" "system")))
          (replace 'check
            (lambda _
-             (let ((build-directory
-                    (car (scandir "build" (cut string-prefix? "lib" <>)))))
-               (setenv "PYTHONPATH"
-                       (string-append "./build/" build-directory ":"
-                                      (getenv "PYTHONPATH")))
-               (invoke "pytest" "-vv")))))))
+             (invoke "pytest" "-vv"))))))
     (native-inputs
      `(("python-hypothesis" ,python-hypothesis)
        ("python-pytest" ,python-pytest)))
@@ -1179,9 +1168,7 @@ none of them have everything that I'd like, so here's one more.  It uses
            (lambda* (#:key inputs #:allow-other-keys)
              (substitute* "libnacl/__init__.py"
                (("/usr/local/lib/libsodium.so")
-                (string-append (assoc-ref inputs "libsodium")
-                               "/lib/libsodium.so")))
-             #t)))))
+                (search-input-file inputs "/lib/libsodium.so"))))))))
     (native-inputs
      `(("python-pyhamcrest" ,python-pyhamcrest)))
     (inputs