diff options
Diffstat (limited to 'gnu/packages/bioinformatics.scm')
| -rw-r--r-- | gnu/packages/bioinformatics.scm | 636 |
1 files changed, 595 insertions, 41 deletions
diff --git a/gnu/packages/bioinformatics.scm b/gnu/packages/bioinformatics.scm index f5e7285193..1cbf85ff6c 100644 --- a/gnu/packages/bioinformatics.scm +++ b/gnu/packages/bioinformatics.scm @@ -27,6 +27,7 @@ #:use-module (guix utils) #:use-module (guix download) #:use-module (guix git-download) + #:use-module (guix hg-download) #:use-module (guix build-system ant) #:use-module (guix build-system gnu) #:use-module (guix build-system cmake) @@ -49,18 +50,23 @@ #:use-module (gnu packages file) #:use-module (gnu packages gawk) #:use-module (gnu packages gcc) + #:use-module (gnu packages gd) + #:use-module (gnu packages image) #:use-module (gnu packages java) #:use-module (gnu packages linux) + #:use-module (gnu packages logging) #:use-module (gnu packages machine-learning) #:use-module (gnu packages maths) #:use-module (gnu packages mpi) #:use-module (gnu packages ncurses) #:use-module (gnu packages pcre) + #:use-module (gnu packages pdf) #:use-module (gnu packages perl) #:use-module (gnu packages pkg-config) #:use-module (gnu packages popt) #:use-module (gnu packages protobuf) #:use-module (gnu packages python) + #:use-module (gnu packages readline) #:use-module (gnu packages ruby) #:use-module (gnu packages statistics) #:use-module (gnu packages tbb) @@ -70,6 +76,7 @@ #:use-module (gnu packages vim) #:use-module (gnu packages web) #:use-module (gnu packages xml) + #:use-module (gnu packages xorg) #:use-module (gnu packages zip) #:use-module (srfi srfi-1)) @@ -215,7 +222,7 @@ computational cluster.") (define-public bedtools (package (name "bedtools") - (version "2.25.0") + (version "2.26.0") (source (origin (method url-fetch) (uri (string-append "https://github.com/arq5x/bedtools2/archive/v" @@ -223,7 +230,7 @@ computational cluster.") (file-name (string-append name "-" version ".tar.gz")) (sha256 (base32 - "1ywcy3yfwzhl905b51l0ffjia55h75vv3mw5xkvib04pp6pj548m")))) + "0xvri5hnp2iim1cx6mcd5d9f102p5ql41x69rd6106x1c17pinqm")))) (build-system gnu-build-system) (native-inputs `(("python" ,python-2))) (inputs `(("samtools" ,samtools) @@ -251,6 +258,51 @@ intervals from multiple files in widely-used genomic file formats such as BAM, BED, GFF/GTF, VCF.") (license license:gpl2))) +;; Later releases of bedtools produce files with more columns than +;; what Ribotaper expects. +(define-public bedtools-2.18 + (package (inherit bedtools) + (name "bedtools") + (version "2.18.0") + (source (origin + (method url-fetch) + (uri (string-append "https://github.com/arq5x/bedtools2/" + "archive/v" version ".tar.gz")) + (file-name (string-append name "-" version ".tar.gz")) + (sha256 + (base32 + "05vrnr8yp7swfagshzpgqmzk1blnwnq8pq5pckzi1m26w98d63vf")))))) + +(define-public ribotaper + (package + (name "ribotaper") + (version "1.3.1") + (source (origin + (method url-fetch) + (uri (string-append "https://ohlerlab.mdc-berlin.de/" + "files/RiboTaper/RiboTaper_Version_" + version ".tar.gz")) + (sha256 + (base32 + "0ykjbps1y3z3085q94npw8i9x5gldc6shy8vlc08v76zljsm07hv")))) + (build-system gnu-build-system) + (inputs + `(("bedtools" ,bedtools-2.18) + ("samtools" ,samtools-0.1) + ("r" ,r) + ("r-foreach" ,r-foreach) + ("r-xnomial" ,r-xnomial) + ("r-domc" ,r-domc) + ("r-multitaper" ,r-multitaper) + ("r-seqinr" ,r-seqinr))) + (home-page "https://ohlerlab.mdc-berlin.de/software/RiboTaper_126/") + (synopsis "Define translated ORFs using ribosome profiling data") + (description + "Ribotaper is a method for defining translated @dfn{open reading +frames} (ORFs) using ribosome profiling (ribo-seq) data. This package +provides the Ribotaper pipeline.") + (license license:gpl3+))) + (define-public bioawk (package (name "bioawk") @@ -421,7 +473,7 @@ into separate processes; and more.") (define-public blast+ (package (name "blast+") - (version "2.2.31") + (version "2.4.0") (source (origin (method url-fetch) (uri (string-append @@ -429,7 +481,7 @@ into separate processes; and more.") version "/ncbi-blast-" version "+-src.tar.gz")) (sha256 (base32 - "19gq6as4k1jrgsd26158ads6h7v4jca3h4r5dzg1y0m6ya50x5ph")) + "14n9jik6vhiwjd3m7bach4xj1pzfn0szbsbyfxybd9l9cc43b6mb")) (modules '((guix build utils))) (snippet '(begin @@ -1439,6 +1491,40 @@ accessing bigWig files.") (native-inputs `(("python-setuptools" ,python2-setuptools)))))) +(define-public python-dendropy + (package + (name "python-dendropy") + (version "4.1.0") + (source + (origin + (method url-fetch) + (uri (pypi-uri "DendroPy" version)) + (sha256 + (base32 + "1jfz7gp18wph311w1yygbvjanb3n5mdqal439bb6myw41dwb5m63")) + ;; There are two known test failures that will be fixed in the next + ;; release after 4.1.0. + ;; https://github.com/jeetsukumaran/DendroPy/issues/48 + (patches (search-patches + "python-dendropy-exclude-failing-tests.patch")))) + (build-system python-build-system) + (home-page "http://packages.python.org/DendroPy/") + (synopsis "Library for phylogenetics and phylogenetic computing") + (description + "DendroPy is a library for phylogenetics and phylogenetic computing: reading, +writing, simulation, processing and manipulation of phylogenetic +trees (phylogenies) and characters.") + (license license:bsd-3) + (properties `((python2-variant . ,(delay python2-dendropy)))))) + +(define-public python2-dendropy + (let ((base (package-with-python2 (strip-python2-variant python-dendropy)))) + (package + (inherit base) + (native-inputs `(("python2-setuptools" ,python2-setuptools) + ,@(package-native-inputs base)))))) + + (define-public deeptools (package (name "deeptools") @@ -1482,7 +1568,7 @@ identify enrichments with functional annotations of the genome.") (define-public diamond (package (name "diamond") - (version "0.8.7") + (version "0.8.15") (source (origin (method url-fetch) (uri (string-append @@ -1491,7 +1577,7 @@ identify enrichments with functional annotations of the genome.") (file-name (string-append name "-" version ".tar.gz")) (sha256 (base32 - "15r7gcrqc4pv5d4kvv530zc3xnni92c74y63zrxzidriss7591yx")))) + "14n0p28b4i5j8vvz1fl4xj1gxnpg98bj0kr3i90mhn7miwr4pkpw")))) (build-system cmake-build-system) (arguments '(#:tests? #f ; no "check" target @@ -1517,6 +1603,75 @@ data and settings.") (license (license:non-copyleft "file://src/COPYING" "See src/COPYING in the distribution.")))) +(define-public eigensoft + (let ((revision "1") + (commit "b14d1e202e21e532536ff8004f0419cd5e259dc7")) + (package + (name "eigensoft") + (version (string-append "6.1.2-" + revision "." + (string-take commit 9))) + (source + (origin + (method git-fetch) + (uri (git-reference + (url "https://github.com/DReichLab/EIG.git") + (commit commit))) + (file-name (string-append "eigensoft-" commit "-checkout")) + (sha256 + (base32 + "0f5m6k2j5c16xc3xbywcs989xyc26ncy1zfzp9j9n55n9r4xcaiq")) + (modules '((guix build utils))) + ;; Remove pre-built binaries. + (snippet '(begin + (delete-file-recursively "bin") + (mkdir "bin") + #t)))) + (build-system gnu-build-system) + (arguments + `(#:tests? #f ; There are no tests. + #:make-flags '("CC=gcc") + #:phases + (modify-phases %standard-phases + ;; There is no configure phase, but the Makefile is in a + ;; sub-directory. + (replace 'configure + (lambda _ + (chdir "src") + ;; The link flags are incomplete. + (substitute* "Makefile" + (("-lgsl") "-lgsl -lm -llapack -llapacke -lpthread")) + #t)) + ;; The provided install target only copies executables to + ;; the "bin" directory in the build root. + (add-after 'install 'actually-install + (lambda* (#:key outputs #:allow-other-keys) + (let* ((out (assoc-ref outputs "out")) + (bin (string-append out "/bin"))) + (mkdir-p bin) + (for-each (lambda (file) + (install-file file bin)) + (find-files "../bin" ".*")) + #t)))))) + (inputs + `(("gsl" ,gsl) + ("lapack" ,lapack) + ("openblas" ,openblas) + ("perl" ,perl) + ("gfortran" ,gfortran "lib"))) + (home-page "https://github.com/DReichLab/EIG") + (synopsis "Tools for population genetics") + (description "The EIGENSOFT package provides tools for population +genetics and stratification correction. EIGENSOFT implements methods commonly +used in population genetics analyses such as PCA, computation of Tracy-Widom +statistics, and finding related individuals in structured populations. It +comes with a built-in plotting script and supports multiple file formats and +quantitative phenotypes.") + ;; The license of the eigensoft tools is Expat, but since it's + ;; linking with the GNU Scientific Library (GSL) the effective + ;; license is the GPL. + (license license:gpl3+)))) + (define-public edirect (package (name "edirect") @@ -2170,7 +2325,7 @@ manipulating HTS data.") (define-public htslib (package (name "htslib") - (version "1.2.1") + (version "1.3.1") (source (origin (method url-fetch) (uri (string-append @@ -2178,7 +2333,7 @@ manipulating HTS data.") version "/htslib-" version ".tar.bz2")) (sha256 (base32 - "1c32ssscbnjwfw3dra140fq7riarp2x990qxybh34nr1p5r17nxx")))) + "1rja282fwdc25ql6izkhdyh8ppw8x2fs0w0js78zgkmqjlikmma9")))) (build-system gnu-build-system) (arguments `(#:phases @@ -2301,6 +2456,87 @@ command, or queried for specific k-mers with @code{jellyfish query}.") ;; files such as lib/jsoncpp.cpp are released under the Expat license. (license (list license:gpl3+ license:expat)))) +(define-public khmer + (package + (name "khmer") + (version "2.0") + (source + (origin + (method url-fetch) + (uri (pypi-uri "khmer" version)) + (sha256 + (base32 + "0wb05shqh77v00256qlm68vbbx3kl76fyzihszbz5nhanl4ni33a")) + (patches (search-patches "khmer-use-libraries.patch")))) + (build-system python-build-system) + (arguments + `(#:phases + (modify-phases %standard-phases + (add-after 'unpack 'set-paths + (lambda* (#:key inputs outputs #:allow-other-keys) + ;; Delete bundled libraries. + (delete-file-recursively "third-party/zlib") + (delete-file-recursively "third-party/bzip2") + ;; Replace bundled seqan. + (let* ((seqan-all "third-party/seqan") + (seqan-include (string-append + seqan-all "/core/include"))) + (delete-file-recursively seqan-all) + (copy-recursively (string-append (assoc-ref inputs "seqan") + "/include/seqan") + (string-append seqan-include "/seqan"))) + ;; We do not replace the bundled MurmurHash as the canonical + ;; repository for this code 'SMHasher' is unsuitable for + ;; providing a library. See + ;; https://lists.gnu.org/archive/html/guix-devel/2016-06/msg00977.html + #t)) + (add-after 'unpack 'set-cc + (lambda _ + (setenv "CC" "gcc") + #t)) + ;; It is simpler to test after installation. + (delete 'check) + (add-after 'install 'post-install-check + (lambda* (#:key inputs outputs #:allow-other-keys) + (let ((out (assoc-ref outputs "out"))) + (setenv "PATH" + (string-append + (getenv "PATH") + ":" + (assoc-ref outputs "out") + "/bin")) + (setenv "PYTHONPATH" + (string-append + (getenv "PYTHONPATH") + ":" + out + "/lib/python" + (string-take (string-take-right + (assoc-ref inputs "python") 5) 3) + "/site-packages")) + (with-directory-excursion "build" + (zero? (system* "nosetests" "khmer" "--attr" + "!known_failing"))))))))) + (native-inputs + `(("seqan" ,seqan) + ("python-nose" ,python-nose))) + (inputs + `(("zlib" ,zlib) + ("bzip2" ,bzip2) + ("python-screed" ,python-screed) + ("python-bz2file" ,python-bz2file))) + (home-page "https://khmer.readthedocs.org/") + (synopsis "K-mer counting, filtering and graph traversal library") + (description "The khmer software is a set of command-line tools for +working with DNA shotgun sequencing data from genomes, transcriptomes, +metagenomes and single cells. Khmer can make de novo assemblies faster, and +sometimes better. Khmer can also identify and fix problems with shotgun +data.") + ;; When building on i686, armhf and mips64el, we get the following error: + ;; error: ['khmer', 'khmer.tests', 'oxli'] require 64-bit operating system + (supported-systems '("x86_64-linux")) + (license license:bsd-3))) + (define-public macs (package (name "macs") @@ -2333,7 +2569,7 @@ sequencing tag position and orientation.") (define-public mafft (package (name "mafft") - (version "7.267") + (version "7.299") (source (origin (method url-fetch) (uri (string-append @@ -2342,7 +2578,7 @@ sequencing tag position and orientation.") (file-name (string-append name "-" version ".tgz")) (sha256 (base32 - "1xl6xq1rfxkws0svrlhyqxhhwbv6r77jwblsdpcyiwzsscw6wlk0")))) + "1pwwdy5a17ggx8h9v9y712ilswj27dc3d23r65l56jgjz67y5zc0")))) (build-system gnu-build-system) (arguments `(#:tests? #f ; no automated tests, though there are tests in the read me @@ -2408,7 +2644,7 @@ sequences).") (define-public metabat (package (name "metabat") - (version "0.26.1") + (version "0.26.3") (source (origin (method url-fetch) (uri (string-append @@ -2417,31 +2653,40 @@ sequences).") (file-name (string-append name "-" version ".tar.bz2")) (sha256 (base32 - "0vgrhbaxg4dkxyax2kbigak7w0arhqvw0szwp6gd9wmyilc44kfa")))) + "1vpfvgsn8wdsv1g7z73zxcncskx7dy7bw5msg1hhibk25ay11pyg")))) (build-system gnu-build-system) (arguments `(#:phases (modify-phases %standard-phases (add-after 'unpack 'fix-includes - (lambda _ - (substitute* "SConstruct" - (("/include/bam/bam.h") - "/include/samtools/bam.h")) - (substitute* "src/BamUtils.h" - (("^#include \"bam/bam\\.h\"") - "#include \"samtools/bam.h\"") - (("^#include \"bam/sam\\.h\"") - "#include \"samtools/sam.h\"")) - (substitute* "src/KseqReader.h" - (("^#include \"bam/kseq\\.h\"") - "#include \"samtools/kseq.h\"")) - #t)) + (lambda _ + (substitute* "src/BamUtils.h" + (("^#include \"bam/bam\\.h\"") + "#include \"samtools/bam.h\"") + (("^#include \"bam/sam\\.h\"") + "#include \"samtools/sam.h\"")) + (substitute* "src/KseqReader.h" + (("^#include \"bam/kseq\\.h\"") + "#include \"htslib/kseq.h\"")) + #t)) (add-after 'unpack 'fix-scons - (lambda _ - (substitute* "SConstruct" ; Do not distribute README - (("^env\\.Install\\(idir_prefix, 'README\\.md'\\)") - "")) - #t)) + (lambda* (#:key inputs #:allow-other-keys) + (substitute* "SConstruct" + (("^htslib_dir = 'samtools'") + (string-append "hitslib_dir = '" + (assoc-ref inputs "htslib") + "'")) + (("^samtools_dir = 'samtools'") + (string-append "samtools_dir = '" + (assoc-ref inputs "htslib") + "'")) + (("^findStaticOrShared\\('bam', hts_lib") + (string-append "findStaticOrShared('bam', '" + (assoc-ref inputs "samtools") + "/lib'")) + ;; Do not distribute README. + (("^env\\.Install\\(idir_prefix, 'README\\.md'\\)") "")) + #t)) (delete 'configure) (replace 'build (lambda* (#:key inputs outputs #:allow-other-keys) @@ -2451,16 +2696,10 @@ sequences).") "PREFIX=" (assoc-ref outputs "out")) (string-append - "HTSLIB_DIR=" - (assoc-ref inputs "htslib")) - (string-append - "SAMTOOLS_DIR=" - (assoc-ref inputs "samtools")) - (string-append "BOOST_ROOT=" (assoc-ref inputs "boost")) "install")))) - ;; check and install carried out during build phase + ;; Check and install are carried out during build phase. (delete 'check) (delete 'install)))) (inputs @@ -2919,6 +3158,75 @@ while RNA-seq specific modules evaluate sequencing saturation, mapped reads distribution, coverage uniformity, strand specificity, etc.") (license license:gpl3+))) +(define-public seek + ;; There are no release tarballs. According to the installation + ;; instructions at http://seek.princeton.edu/installation.jsp, the latest + ;; stable release is identified by this changeset ID. + (let ((changeset "2329130") + (revision "1")) + (package + (name "seek") + (version (string-append "0-" revision "." changeset)) + (source (origin + (method hg-fetch) + (uri (hg-reference + (url "https://bitbucket.org/libsleipnir/sleipnir") + (changeset changeset))) + (sha256 + (base32 + "0qrvilwh18dpbhkf92qvxbmay0j75ra3jg2wrhz67gf538zzphsx")))) + (build-system gnu-build-system) + (arguments + `(#:modules ((srfi srfi-1) + (guix build gnu-build-system) + (guix build utils)) + #:phases + (let ((dirs '("SeekMiner" + "SeekEvaluator" + "SeekPrep" + "Distancer" + "Data2DB" + "PCL2Bin"))) + (modify-phases %standard-phases + (add-before 'configure 'bootstrap + (lambda _ + (zero? (system* "bash" "gen_auto")))) + (add-after 'build 'build-additional-tools + (lambda* (#:key make-flags #:allow-other-keys) + (every (lambda (dir) + (with-directory-excursion (string-append "tools/" dir) + (zero? (apply system* "make" make-flags)))) + dirs))) + (add-after 'install 'install-additional-tools + (lambda* (#:key make-flags #:allow-other-keys) + (fold (lambda (dir result) + (with-directory-excursion (string-append "tools/" dir) + (and result + (zero? (apply system* + `("make" ,@make-flags "install")))))) + #t dirs))))))) + (inputs + `(("gsl" ,gsl) + ("boost" ,boost) + ("libsvm" ,libsvm) + ("readline" ,readline) + ("gengetopt" ,gengetopt) + ("log4cpp" ,log4cpp))) + (native-inputs + `(("autoconf" ,autoconf) + ("automake" ,automake) + ("perl" ,perl))) + (home-page "http://seek.princeton.edu") + (synopsis "Gene co-expression search engine") + (description + "SEEK is a computational gene co-expression search engine. SEEK provides +biologists with a way to navigate the massive human expression compendium that +now contains thousands of expression datasets. SEEK returns a robust ranking +of co-expressed genes in the biological area of interest defined by the user's +query genes. It also prioritizes thousands of expression datasets according +to the user's query of interest.") + (license license:cc-by3.0)))) + (define-public samtools (package (name "samtools") @@ -3359,6 +3667,44 @@ optimize the sequencing depth, or to screen multiple libraries to avoid low complexity samples.") (license license:gpl3+))) +(define-public python-screed + (package + (name "python-screed") + (version "0.9") + (source + (origin + (method url-fetch) + (uri (pypi-uri "screed" version)) + (sha256 + (base32 + "18czszp9fkx3j6jr7y5kp6dfialscgddk05mw1zkhh2zhn0jd8i0")))) + (build-system python-build-system) + (arguments + `(#:phases + (modify-phases %standard-phases + (replace 'check + (lambda _ + (setenv "PYTHONPATH" + (string-append (getenv "PYTHONPATH") ":.")) + (zero? (system* "nosetests" "--attr" "!known_failing"))))))) + (native-inputs + `(("python-nose" ,python-nose))) + (inputs + `(("python-bz2file" ,python-bz2file))) + (home-page "http://github.com/dib-lab/screed/") + (synopsis "Short read sequence database utilities") + (description "Screed parses FASTA and FASTQ files and generates databases. +Values such as sequence name, sequence description, sequence quality and the +sequence itself can be retrieved from these databases.") + (license license:bsd-3))) + +(define-public python2-screed + (let ((base (package-with-python2 (strip-python2-variant python-screed)))) + (package + (inherit base) + (native-inputs `(("python2-setuptools" ,python2-setuptools) + ,@(package-native-inputs base)))))) + (define-public sra-tools (package (name "sra-tools") @@ -3600,7 +3946,7 @@ application of SortMeRNA is filtering rRNA from metatranscriptomic data.") (define-public star (package (name "star") - (version "2.5.1b") + (version "2.5.2a") (source (origin (method url-fetch) (uri (string-append "https://github.com/alexdobin/STAR/archive/" @@ -3608,7 +3954,7 @@ application of SortMeRNA is filtering rRNA from metatranscriptomic data.") (file-name (string-append name "-" version ".tar.gz")) (sha256 (base32 - "0wzcfhkg10apnh0y73xlarfa79xxwxdizicbdl11wb48awk44iq4")) + "0xjlsm4p9flln111hv4xx7xy94c2nl53zvdvbk9winmiradjsdra")) (modules '((guix build utils))) (snippet '(begin @@ -3665,6 +4011,8 @@ by seed clustering and stitching procedure. In addition to unbiased de novo detection of canonical junctions, STAR can discover non-canonical splices and chimeric (fusion) transcripts, and is also capable of mapping full-length RNA sequences.") + ;; Only 64-bit systems are supported according to the README. + (supported-systems '("x86_64-linux" "mips64el-linux")) ;; STAR is licensed under GPLv3 or later; htslib is MIT-licensed. (license license:gpl3+))) @@ -3869,7 +4217,7 @@ data types as well.") (define-public vsearch (package (name "vsearch") - (version "2.0.0") + (version "2.0.1") (source (origin (method url-fetch) @@ -3879,7 +4227,7 @@ data types as well.") (file-name (string-append name "-" version ".tar.gz")) (sha256 (base32 - "1sd57abgx077icqrbj36jq9q7pdpzc6dbics2pn1555kisq2jhfh")) + "0q7szwbf7r29yxkhb415a8i51vj87kvl5ap7h09w7k9ycb2ywvzw")) (modules '((guix build utils))) (snippet '(begin @@ -4191,6 +4539,30 @@ In addition, a few low-level concrete subclasses of general interest (e.g. S4Vectors package itself.") (license license:artistic2.0))) +(define-public r-seqinr + (package + (name "r-seqinr") + (version "3.1-3") + (source + (origin + (method url-fetch) + (uri (cran-uri "seqinr" version)) + (sha256 + (base32 + "0bbjfwbqg74wsamb3iz01g0ssdpdpg65gh00y9xlnpk4wb990n4n")))) + (build-system r-build-system) + (propagated-inputs + `(("r-ade4" ,r-ade4))) + (inputs + `(("zlib" ,zlib))) + (home-page "http://seqinr.r-forge.r-project.org/") + (synopsis "Biological sequences retrieval and analysis") + (description + "This package provides tools for exploratory data analysis and data +visualization of biological sequence (DNA and protein) data. It also includes +utilities for sequence data management under the ACNUC system.") + (license license:gpl2+))) + (define-public r-iranges (package (name "r-iranges") @@ -4246,6 +4618,31 @@ translation between different chromosome sequence naming conventions (e.g., names in their natural, rather than lexicographic, order.") (license license:artistic2.0))) +(define-public r-edger + (package + (name "r-edger") + (version "3.14.0") + (source (origin + (method url-fetch) + (uri (bioconductor-uri "edgeR" version)) + (sha256 + (base32 + "14vrygy7rz5ngaap4kgkvr3j18y5l6m742n79h68plk6iqgmsskn")))) + (properties `((upstream-name . "edgeR"))) + (build-system r-build-system) + (propagated-inputs + `(("r-limma" ,r-limma))) + (home-page "http://bioinf.wehi.edu.au/edgeR") + (synopsis "EdgeR does empirical analysis of digital gene expression data") + (description "This package can do differential expression analysis of +RNA-seq expression profiles with biological replication. It implements a range +of statistical methodology based on the negative binomial distributions, +including empirical Bayes estimation, exact tests, generalized linear models +and quasi-likelihood tests. It be applied to differential signal analysis of +other types of genomic data that produce counts, including ChIP-seq, SAGE and +CAGE.") + (license license:gpl2+))) + (define-public r-variantannotation (package (name "r-variantannotation") @@ -4278,6 +4675,25 @@ names in their natural, rather than lexicographic, order.") coding changes and predict coding outcomes.") (license license:artistic2.0))) +(define-public r-limma + (package + (name "r-limma") + (version "3.28.14") + (source (origin + (method url-fetch) + (uri (bioconductor-uri "limma" version)) + (sha256 + (base32 + "1jgn66ajafhjlqpfcw2p85h6ah8mgmz66znmsw6pcapia7d34akw")))) + (build-system r-build-system) + (home-page "http://bioinf.wehi.edu.au/limma") + (synopsis "Package for linear models for microarray and RNA-seq data") + (description "This package can be used for the analysis of gene expression +studies, especially the use of linear models for analysing designed experiments +and the assessment of differential expression. The analysis methods apply to +different technologies, including microarrays, RNA-seq, and quantitative PCR.") + (license license:gpl2+))) + (define-public r-xvector (package (name "r-xvector") @@ -5237,6 +5653,115 @@ two-dimensional genome scans.") libraries for systems that do not have these available via other means.") (license license:artistic2.0))) +(define-public emboss + (package + (name "emboss") + (version "6.5.7") + (source (origin + (method url-fetch) + (uri (string-append "ftp://emboss.open-bio.org/pub/EMBOSS/old/" + (version-major+minor version) ".0/" + "EMBOSS-" version ".tar.gz")) + (sha256 + (base32 + "0vsmz96gc411yj2iyzdrsmg4l2n1nhgmp7vrgzlxx3xixv9xbf0q")))) + (build-system gnu-build-system) + (arguments + `(#:configure-flags + (list (string-append "--with-hpdf=" + (assoc-ref %build-inputs "libharu"))) + #:phases + (modify-phases %standard-phases + (add-after 'unpack 'fix-checks + (lambda _ + ;; The PNGDRIVER tests check for the presence of libgd, libpng + ;; and zlib, but assume that they are all found at the same + ;; prefix. + (substitute* "configure.in" + (("CHECK_PNGDRIVER") + "LIBS=\"$LIBS -lgd -lpng -lz -lm\" +AC_DEFINE([PLD_png], [1], [Define to 1 if PNG support is available]) +AM_CONDITIONAL(AMPNG, true)")) + #t)) + (add-after 'unpack 'disable-update-check + (lambda _ + ;; At build time there is no connection to the Internet, so + ;; looking for updates will not work. + (substitute* "Makefile.am" + (("\\$\\(bindir\\)/embossupdate") "")) + #t)) + (add-before 'configure 'autogen + (lambda _ (zero? (system* "autoreconf" "-vif"))))))) + (inputs + `(("perl" ,perl) + ("libpng" ,libpng) + ("gd" ,gd) + ("libx11" ,libx11) + ("libharu" ,libharu) + ("zlib" ,zlib))) + (native-inputs + `(("autoconf" ,autoconf) + ("automake" ,automake) + ("libtool" ,libtool) + ("pkg-config" ,pkg-config))) + (home-page "http://emboss.sourceforge.net") + (synopsis "Molecular biology analysis suite") + (description "EMBOSS is the \"European Molecular Biology Open Software +Suite\". EMBOSS is an analysis package specially developed for the needs of +the molecular biology (e.g. EMBnet) user community. The software +automatically copes with data in a variety of formats and even allows +transparent retrieval of sequence data from the web. It also provides a +number of libraries for the development of software in the field of molecular +biology. EMBOSS also integrates a range of currently available packages and +tools for sequence analysis into a seamless whole.") + (license license:gpl2+))) + +(define-public bits + (let ((revision "1") + (commit "3cc4567896d9d6442923da944beb704750a08d2d")) + (package + (name "bits") + ;; The version is 2.13.0 even though no release archives have been + ;; published as yet. + (version (string-append "2.13.0-" revision "." (string-take commit 9))) + (source (origin + (method git-fetch) + (uri (git-reference + (url "https://github.com/arq5x/bits.git") + (commit commit))) + (file-name (string-append name "-" version "-checkout")) + (sha256 + (base32 + "17n2kffk4kmhivd8c98g2vr6y1s23vbg4sxlxs689wni66797hbs")))) + (build-system gnu-build-system) + (arguments + `(#:tests? #f ;no tests included + #:phases + (modify-phases %standard-phases + (delete 'configure) + (add-after 'unpack 'remove-cuda + (lambda _ + (substitute* "Makefile" + ((".*_cuda") "") + (("(bits_test_intersections) \\\\" _ match) match)) + #t)) + (replace 'install + (lambda* (#:key outputs #:allow-other-keys) + (copy-recursively + "bin" (string-append (assoc-ref outputs "out") "/bin")) + #t))))) + (inputs + `(("gsl" ,gsl) + ("zlib" ,zlib))) + (home-page "https://github.com/arq5x/bits") + (synopsis "Implementation of binary interval search algorithm") + (description "This package provides an implementation of the +BITS (Binary Interval Search) algorithm, an approach to interval set +intersection. It is especially suited for the comparison of diverse genomic +datasets and the exploration of large datasets of genome +intervals (e.g. genes, sequence alignments).") + (license license:gpl2)))) + (define-public piranha ;; There is no release tarball for the latest version. The latest commit is ;; older than one year at the time of this writing. @@ -5372,3 +5897,32 @@ group or two ChIP groups run under different conditions.") (description "This program compares version strings. It intends to be a replacement for strverscmp.") (license license:gpl3+)))) + +(define-public multiqc + (package + (name "multiqc") + (version "0.6") + (source + (origin + (method url-fetch) + (uri (pypi-uri "multiqc" version)) + (sha256 + (base32 + "0avw11h63ldpxy5pizc3wl1wa01ha7q10wb240nggsjz3jaqvyiy")))) + (build-system python-build-system) + (propagated-inputs + `(("python-jinja2" ,python-jinja2) + ("python-simplejson" ,python-simplejson) + ("python-pyyaml" ,python-pyyaml) + ("python-click" ,python-click) + ("python-matplotlib" ,python-matplotlib) + ("python-numpy" ,python-numpy))) + (native-inputs + `(("python-setuptools" ,python-setuptools))) + (home-page "http://multiqc.info") + (synopsis "Aggregate bioinformatics analysis reports") + (description + "MultiQC is a tool to aggregate bioinformatics results across many +samples into a single report. It contains modules for a large number of +common bioinformatics tools.") + (license license:gpl3))) |